Global Cardiovascular Health Research Group

Global Cardiovascular Health Research Group

Research topic

Cardiovascular diseases  (CVD) are the leading cause of morbidity and mortality worldwide. The contribution of low- and middle-income countries to the global burden of CVD is estimated at 80%, characterized by higher mortality rates and high burden of morbidity in part due to sub-optimal care related to health system challenges. Our work aims to study cardiovascular risk factors and disease outcomes internationally and develop, implement and scale-up cost-efficient approaches to support clinical decision-making for primary and secondary prevention of CVD globally.

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide with low- and middle income countries being disproportionally affected. Our work aims to study cardiovascular risk factors and health outcomes internationally and develop, implement and scale-up cost-efficient approaches for primary and secondary prevention of cardiovascular disease globally to contribute towards equity in health and well-being for all.

The Global Cardiovascular Health research group is involved in multi-center international studies on common cardiovascular risk factors and disease outcomes and clinical trials to test the effectiveness and impact of  evidence-based interventions for primary and secondary prevention of cardiovascular diseases (CVD) including low-cost medication. Research takes place in partnership with academic and health care organisations globally including African and Asian countries, such as South Africa, Tanzania, Kenya, Ghana, Nigeria, Indonesia, Malaysia or Cambodia. 

Managing cardiovascular risk factors uitklapper, klik om te openen

Evidence-based clinical guidelines on CVD prevention suggest controlling modifiable risk factors to reduce the recurrence of cardiovascular events and mortality. The SUrvey of Risk Factors (SURF) study, a clinical audit aims to assess cardiovascular risk factor recording and management for secondary prevention globally to ensure good standard of care in daily practice and to improve outcomes through the systematic review of routine care.

Hypertension, type 2 diabetes and HIV

Many countries struggle to find the best way to treat hypertension and type 2 diabetes, therefore many patients receive sub-optimal care, especially vulnerable groups in society. The European Commission/Global Alliance for Chronic Diseases-funded Scale-Up Hypertension and Diabetes Care (SCUBY) study assesses how the implementation and scale-up of an integrated chronic care package impacts hypertension and diabetes outcomes in Cambodia, Slovenia and Belgium. The lessons on scale-up will benefit policy-makers in other countries with similar contexts.

In the Integrating HIV and hEART health in South Africa (iHEART-SA) study funded by the National Institutes of Health, USA, as part of the ComorbiditieS Implementation Models in People Living with HIV Alliance, innovations for the prevention and management of hypertension and diabetes mellitus are tested to expand the scope of HIV care in a sustainable, scalable and impactful way in South Africa and beyond.

Importance of social determinants uitklapper, klik om te openen

To better understand the impact of urbanization-related environment, societal and biological changes on the development of CVD along the life-course the Global Cardiovascular Health Resarch Group undertakes research in low-resource settings in Kenya, Ghana, South Africa, Tanzania and Indonesia as well as in high income settings such as the Netherlands. The Research on Obesity and Diabetes in African Migrants (RODAM) study has shown high prevalence of cardiometabolic disease in urbanized settings both in Ghana and Europe. Work undertaken as part of the the Ndlovu Cohort Study, South Africa, as well as in urban slums in Nairobi, Kenya and elsewhere show the importance of social determinants for the prevention and management of life-style related cardiovascular risk factor and CVD. 

Early life factors uitklapper, klik om te openen

Early life factors are increasingly recognized as important determinants for subsequent health. Pregnancy cohorts set up in Asia and Africa,  assess the effects of environmental exposures on adverse maternal and child health (PEER-Health study) and consequences of gestational hypertension and diabetes on long-term health of mother and child. The SPOT-Studies in Ghana focus on prediction and  innovative implementation triage strategies for optimal clinical management of hypertensive disorders of pregnancy.

For more information about the scope of the work undertaken by the Global Cardiovascular Health Research Group please see our website:

Research team uitklapper, klik om te openen

Dr. Kerstin Klipstein-Grobusch, PhD 

Prof. Dr. Diederick E Grobbee, MD PhD 

Dr. Martin Heine, PhD

Dr. Sanne Peters,  PhD

Dr. Ilonca Vaartjes, PhD 

Dr. George Downward, MD PhD

Dr. Helene Voogdt-Pruis, PhD

Dr. Joyce Browne, MD PhD

Prof. Dr. Michiel Bots MD PhD 

Dr. Alinda Vos, MD PhD 

Dr. Daniel Boateng, PhD

Dr. Karine Scheuermaier, MD PhD 

Dr. Hannah Brown Amaokoh, MD PhD 

Dr. Ishaku Salisu, MD PhD

Dr. Juliana Kagura, PhD

Dr. Engelbert Nonterah, PhD

Dr. Kwame Adu-Bonsaffoh, MD MSc

Dr. Roberta Lamptey, MD PhD

Dr. Larske Soepnel, MD PhD

PhD students

There are several PhD students, most of them based internationally, involved in the Global Cardiovascular Health Research group;

Ojo Adedajo, MD

Kingsley Boakye, MPhil

Anna Marza Florensa, MSc

Stephaney Gyaase, MSc

Yvonne Mei Fong Lim, MD

Naiz Majani, MD

Wellington Maruma, MSc

Liu Mingwei, MSc

Solomon Nyame, MA

Timothy Olanrewaju, MD MSc 

Klaartje Olde Loohuis, MD

Patane Shilabye, MSc

Linda Paulo Simon, MD MSc

Emmanuel Srofenyoh, MD MA

Milka Njeri Wanjohi, MSc

Victor Williams, MD MSc

Dina Youssef, MD

Contact uitklapper, klik om te openen

Associate Professor Kerstin Klipstein-Grobusch

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