dr. D. (Dennis) Beringer

dr. D. (Dennis) Beringer

Assistant Professor
dr. D. (Dennis) Beringer
  • Laboratory for Translational Immunology (LTI)

Research Programs



Dr Dennis Beringer is an assistant professor in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. He obtained his PhD at Utrecht University in the field of structural biology. After which he moved to Monash University, Australia, where he investigated the molecular details of T cell receptor (TCR) – antigen interactions in autoimmune diseases and cancer. Intrigued by TCR biology, he returned to Utrecht to join the group of Jürgen Kuball at the UMCU in 2016 to study the molecular determinants of tumor reactive γδTCRs, for which he received a Marie Curie Individual Fellowship. Currently, he and his team are focusing on the optimization of existing and the development of novel γδ-TCR based therapeutics for cancer therapy, with a special emphasis on a new class of bispecific T cell engagers called GABs.

Research Output (10)

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

van Diest Eline, Nicolasen Mara J T, Kramer Lovro, Zheng Jiali, Hernández-López Patricia, Beringer Dennis X, Kuball Jürgen 5 Jan 2023, In: Frontiers in Immunology. 13

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies

Meringa A D, Hernández-López P, Cleven A, de Witte M, Straetemans T, Kuball J, Beringer D X, Sebestyen Z 2023, In: Frontiers in Immunology. 14 , p. 1-7

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults

Vyborova Anna, Janssen Anke, Gatti Lucrezia, Karaiskaki Froso, Yonika Austin, van Dooremalen Sanne, Sanders Jasper, Beringer Dennis X, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 7 Jul 2022, In: Frontiers in Immunology. 13 , p. 1-13

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Van Diest Eline, Hernández López Patricia, Meringa Angelo D., Vyborova Anna, Karaiskaki Froso, Heijhuurs Sabine, Gumathi Bormin Jan, Van Dooremalen Sanne, Nicolasen Mara J.T., Gatti Lucrezia C.D.E., Johanna Inez, Straetemans Trudy, Sebestyén Zsolt, Beringer Dennis X., Kuball Jürgen 23 Nov 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-15

Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Scheper Wouter, Bongiovanni Laura, de Bruin Alain, Beringer Dennis X., Oostvogels Rimke, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 25 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-12

Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells

Kierkels Guido J J, van Diest Eline, Hernández-López Patricia, Scheper Wouter, de Bruin Anja C M, Frijlink Elselien, Aarts-Riemens Tineke, van Dooremalen Sanne F J, Beringer Dennis X, Oostvogels Rimke, Kramer Lovro, Straetemans Trudy, Uckert Wolfgang, Sebestyén Zsolt, Kuball Jürgen 10 Sep 2021, In: Molecular Therapy - Methods and Clinical Development. 22 , p. 388-400 13 p.

gamma 9 delta 2T cell diversity and the receptor interface with tumor cells

Vyborova Anna, Beringer Dennis X, Fasci Domenico, Karaiskaki Froso, van Diest Eline, Kramer Lovro, de Haas Aram, Sanders Jasper, Janssen Anke, Straetemans Trudy, Olive Daniel, Leusen Jeanette Hw, Boutin Lola, Nedellec Steven, Schwartz Samantha L, Wester Michael J, Lidke Keith A, Scotet Emmanuel, Lidke Diane, Heck Albert Jr, Sebestyen Zsolt, Kuball Jurgen 2 Jun 2020, In: Journal of Clinical Investigation. 130 , p. 4637-4651 15 p.

TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Bongiovanni Laura, de Bruin Alain, Beringer Dennis, van Dooremalen Sanne, Shultz Leonard D, Ishikawa Fumihiko, Sebestyen Zsolt, Straetemans Trudy, Kuball Jürgen 5 Feb 2020, In: Journal of Leukocyte Biology. 107 , p. 1069-1079 11 p.

gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Janssen Anke, Villacorta Hidalgo José, Beringer Dennis X, van Dooremalen Sanne F.J., Fernando Febilla, van Diest Eline, Terrizzi Antonela R, Bronsert Peter, Kock Sylvia, Schmitt-Graeff Annette, Werner Martin, Heise Kerstin, Follo Marie, Straetemans Trudy, Sebestyen Zsolt, Chudakov Dmitriy M, Kasatskaya Sofya A, Frenkel Felix E, Ravens Sarina, Spierings Eric, Prinz Immo, Küppers Ralf, Malkovsky Miroslav, Fisch Paul, Kuball Jurgen 4 Feb 2020, In: Cancer Immunology Research. 8 , p. 530-543 14 p.

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 Oct 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

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