dr. J.A.M. (Jose) BorghansAssociate Professor
- Laboratory for Translational Immunology (LTI)
José Borghans runs an interdisciplinary research group, with a main focus on the quantification of leukocyte dynamics. She was originally trained as a theoretical immunologist at Utrecht University, and obtained her PhD in 2000 on studies of lymphocyte and MHC diversity. After her PhD, she started to work in experimental immunology laboratories, aiming to bridge the gap between wet lab experiments and mathematical modelling. Funded by a Marie-Curie Fellowship, she worked as a post-doctoral fellow at the Institut Pasteur in Paris studying lymphocyte homeostasis. During another postdoctoral period, funded by an NWO Veni grant, she worked at Sanquin Research in Amsterdam to study lymphocyte dynamics in HIV infection. She has been working at UMCU since 2004, funded by several NWO grants, and was appointed Associate Professor in 2009. She has formed an interdisciplinary research group with Kiki Tesselaar, which facilitates the close integration of experimental and mathematical immunology. Using state of the art immunological techniques, including in vivo stable isotope labeling in mice and men, the group studies the dynamics of different types of leukocytes in homeostasis, during healthy aging and in different diseases, including leukemia, HIV infection, and post-stem cell transplantation.
Member of the scientific advisory board of Aids Fonds Netherlands
Member of the review panel of the NWO/ALW Open Program Associate Editor of Frontiers Immunology
Member of International Network QuanTI Together with 11 other international institutes, she is part of the International Network QuanTI (Quantitative T-cell immunology) that was awarded a EU-7th Framework Initial Training Grant, which primary objective is to train a new generation of European quantitative immunologists. All partners of the network get together during annual network meetings and international summer schools.
Fellowship and Awards
NWO Aspasia 2009
NWO Vidi 2008
NWO Meervoud 2007
NWO Veni 2002
Marie-Curie Fellowship, EU, 2000
NVVI Thesis Award 2014 for the thesis of Liset Westera, under her supervision
Young Researcher's Award, Unilever, 1996
Research Output (70)
Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination:a systematic review and meta-analysis
van den Berg S. P.H., Warmink K., Borghans J. A.M., Knol M. J., van Baarle D. 1 aug 2019, In: Medical Microbiology and Immunology. 208 , p. 305-321 17 p.
In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow
Baliu-Piqué Mariona, Otto Sigrid A, Borghans José A M, Tesselaar Kiki jun 2019, In: Immunology Letters. 210 , p. 29-32 4 p.
Baliu-Piqué Mariona, Kurniawan Henry, Ravesloot Lars, Verheij Myrddin W., Drylewicz Julia, Lievaart-Peterson Karianne, Borghans José A.M., Koets Ad, Tesselaar Kiki 1 apr 2019, In: Developmental and Comparative Immunology. 93 , p. 1-10 10 p.
Short lifespans of memory T-cells in bone marrow, blood, and lymph nodes suggest that T-cell memory is maintained by continuous self-renewal of recirculating cells
Baliu-Piqué Mariona, Verheij Myrddin W., Drylewicz Julia, Ravesloot Lars, de Boer Rob J., Koets Ad, Tesselaar Kiki, Borghans José A.M. 11 sep 2018, In: Frontiers in Immunology. 9
Current best estimates for the average lifespans of mouse and human leukocytes:reviewing two decades of deuterium-labeling experiments
Borghans José A M, de Boer Rob J, Tesselaar Kiki sep 2018, In: Immunological Reviews. 285 , p. 233-248 16 p.
Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy
Scheltema Nienke M, Kavelaars Xynthia M, Thorburn Kentigern, Hennus Marije P, van Woensel Job B, van der Ent Cornelis K, Borghans José A M, Bont Louis J, Drylewicz Julia 25 jul 2018, In: Vaccine. 36 , p. 4693-4700 8 p.
The antiretroviral CCR5-inhibitor maraviroc effectively reverses HIV latency by phosphorylation of Nf-kappa B
Symons J., vanLelyveld S. F. L., deSpiegelaere W., Wensing A. M. J., Zerbato J. M., vanHam P. M., Drylewicz J., Middel A., Hoepelman A. I. M., Cameron P. U., Lu H. K., Dantanarayana A. I., Borghans J. A. M., Vandekerckhove L., Lewin S. R., Tesselaar K., Nijhuis M. jul 2018, In: Journal of the International AIDS Society [E]. 21 , p. 29-30
Impact of aging, cytomegalovirus infection, and long-term treatment for human immunodeficiency virus on CD8<sup>+</sup> T-Cell subsets
Veel Ellen, Westera Liset, van Gent Rogier, Bont Louis, Otto Sigrid, Ruijsink Bram, Rabouw Huib H., Mudrikova Tania, Wensing Annemarie, Hoepelman Andy I.M., Borghans José A.M., Tesselaar Kiki 21 mrt 2018, In: Frontiers in Immunology [E]. 9 10 p.
van Den Broek Theo, Borghans José A.M., van Wijk Femke 8 mrt 2018, In: Nature Reviews Immunology. 18 , p. 363-373 11 p.
Tak Tamar , Drylewicz Julia, Conemans Lennart, de Boer Rob J., Koenderman Leo, Borghans José A.M., Tesselaar Kiki 21 sep 2017, In: Blood. 130 , p. 1474-1477 4 p.