dr. J.A.M. (Jose) Borghans

Associate Professor
dr. J.A.M. (Jose) Borghans
  • Laboratory for Translational Immunology (LTI)

Research Programs

Infection & Immunity



José Borghans runs an interdisciplinary research group, with a main focus on the quantification of leukocyte dynamics. She was originally trained as a theoretical immunologist at Utrecht University, and obtained her PhD in 2000 on studies of lymphocyte and MHC diversity. After her PhD, she started to work in experimental immunology laboratories, aiming to bridge the gap between wet lab experiments and mathematical modelling. Funded by a Marie-Curie Fellowship, she worked as a post-doctoral fellow at the Institut Pasteur in Paris studying lymphocyte homeostasis. During another postdoctoral period, funded by an NWO Veni grant, she worked at Sanquin Research in Amsterdam to study lymphocyte dynamics in HIV infection. She has been working at UMCU since 2004, funded by several NWO grants, and was appointed Associate Professor in 2009. She has formed an interdisciplinary research group with Kiki Tesselaar, which facilitates the close integration of experimental and mathematical immunology. Using state of the art immunological techniques, including in vivo stable isotope labeling in mice and men, the group studies the dynamics of different types of leukocytes in homeostasis, during healthy aging and in different diseases, including leukemia, HIV infection, and post-stem cell transplantation.

Side Activities

Member of the scientific advisory board of Aids Fonds Netherlands

Member of the review panel of the NWO/ALW Open Program Associate Editor of Frontiers Immunology

Member of International Network QuanTI Together with 11 other international institutes, she is part of the International Network QuanTI (Quantitative T-cell immunology) that was awarded a EU-7th Framework Initial Training Grant, which primary objective is to train a new generation of European quantitative immunologists. All partners of the network get together during annual network meetings and international summer schools.

Fellowship and Awards

NWO Aspasia 2009

NWO Vidi 2008

NWO Meervoud 2007

NWO Veni 2002

Marie-Curie Fellowship, EU, 2000

NVVI Thesis Award 2014 for the thesis of Liset Westera, under her supervision

Young Researcher's Award, Unilever, 1996

Research Output (73)

Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Connell Bridgette J., Hermans Lucas E., Wensing Annemarie M.J., Schellens Ingrid, Schipper Pauline J., van Ham Petra M., de Jong Dorien T.C.M., Otto Sigrid, Mathe Tholakele, Moraba Robert, Borghans José A.M., Papathanasopoulos Maria A., Kruize Zita, Venter Francois W.D., Kootstra Neeltje A., Tempelman Hugo, Tesselaar Kiki, Nijhuis Monique 28 sep 2020, In: Scientific Reports. 10 , p. 1-10

Functional categories of immune inhibitory receptors

Rumpret Matevž, Drylewicz Julia, Ackermans Laura J.E., Borghans José A.M., Medzhitov Ruslan, Meyaard Linde 1 jan 2020, In: Nature Reviews. Immunology. 20 , p. 771-780 10 p.

Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study

Samson Leonard Daniel, van den Berg Sara P. H., Engelfriet Peter, Boots Annemieke M. H., Hendriks Marion, de Rond Lia G. H., de Zeeuw-Brouwer Mary-Iene, Verschuren W. M. Monique, Borghans Jose A. M., Buisman Anne-Marie, van Baarle Debbie 2020, In: Clinical & Translational Immunology (CTI) . 9 , p. 1-18

Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination:a systematic review and meta-analysis

van den Berg S. P.H., Warmink K., Borghans J. A.M., Knol M. J., van Baarle D. 1 aug 2019, In: Medical Microbiology and Immunology. 208 , p. 305-321 17 p.

In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

Baliu-Piqué Mariona, Otto Sigrid A, Borghans José A M, Tesselaar Kiki jun 2019, In: Immunology Letters. 210 , p. 29-32 4 p.

Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

Baliu-Piqué Mariona, Kurniawan Henry, Ravesloot Lars, Verheij Myrddin W., Drylewicz Julia, Lievaart-Peterson Karianne, Borghans José A.M., Koets Ad, Tesselaar Kiki 1 apr 2019, In: Developmental and Comparative Immunology. 93 , p. 1-10 10 p.

Short lifespans of memory T-cells in bone marrow, blood, and lymph nodes suggest that T-cell memory is maintained by continuous self-renewal of recirculating cells

Baliu-Piqué Mariona, Verheij Myrddin W., Drylewicz Julia, Ravesloot Lars, de Boer Rob J., Koets Ad, Tesselaar Kiki, Borghans José A.M. 11 sep 2018, In: Frontiers in Immunology. 9

Current best estimates for the average lifespans of mouse and human leukocytes:reviewing two decades of deuterium-labeling experiments

Borghans José A M, de Boer Rob J, Tesselaar Kiki sep 2018, In: Immunological Reviews. 285 , p. 233-248 16 p.

Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy

Scheltema Nienke M, Kavelaars Xynthia M, Thorburn Kentigern, Hennus Marije P, van Woensel Job B, van der Ent Cornelis K, Borghans José A M, Bont Louis J, Drylewicz Julia 25 jul 2018, In: Vaccine. 36 , p. 4693-4700 8 p.

The antiretroviral CCR5-inhibitor maraviroc effectively reverses HIV latency by phosphorylation of Nf-kappa B

Symons J., vanLelyveld S. F. L., deSpiegelaere W., Wensing A. M. J., Zerbato J. M., vanHam P. M., Drylewicz J., Middel A., Hoepelman A. I. M., Cameron P. U., Lu H. K., Dantanarayana A. I., Borghans J. A. M., Vandekerckhove L., Lewin S. R., Tesselaar K., Nijhuis M. jul 2018, In: Journal of the International AIDS Society [E]. 21 , p. 29-30

All research output

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