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dr. P. (Petra) de Graaf

dr. P. (Petra) de Graaf

Assistant Professor

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Research Output (39)

A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels

Baas R., Lelieveld D., van Teeffelen H.A.A.M., Lijnzaad P., Castelijns B., van Schaik F.M.A., Vermeulen M., Egan D.A., Timmers H.T.M., de Graaf P. 2014, In: Journal of biomolecular screening. 19 , p. 287-296 10 p.

Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function

Outchkourov N.S., Muino J.M., Kaufmann K., van IJcken W., Groot Koerkamp M.J.A., van Leenen D., de Graaf P., Holstege F.C.P., Grosveld F.G., Timmers H.T.M. 2013, In: Cell Reports [E]. 3 , p. 1071-1079 9 p.

Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors

Kleinschmidt M.A., de Graaf P., van Teeffelen H.A.A.M., Timmers H.T.M. 2012, In: PLoS ONE [E]. 7 , p. e41446 1 p.

An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.

Wansleeben C., van Gurp L.C.A., de Graaf P., Mousson F., Timmers H.T.M., Meijlink F. 2011, In: Mechanisms of Development. 128 , p. 279-288 10 p.

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes

Varier Radhika A., Outchkourov Nikolay S., De Graaf Petra, Van Schaik Frederik M.A., Ensing Henk Jan L., Wang Fangwei, Higgins Jonathan M.G., Kops Geert J.P.L., Timmers Hth Marc 1 Dec 2010, In: EMBO Journal. 29 , p. 3967-3978 12 p.

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

Johannes F., Wardenaar R., Colomé-Tatché M., Mousson F., de Graaf P., Mokry M., Guryev V., Timmers H.T.M., Cuppen E., Jansen R.C. 2010, In: Bioinformatics. 26 , p. 1000-1006 7 p.

A phospho/methyl swithch at histone H3 regulates TFIID association with mitotic chromosomes

Varier R.A., Outchkourov N.S., de Graaf P., van Schaik F.M.A., Ensing H.J., Wang F., Higging J.M.G., Kops G.J.P.L., Timmers H.T.M. 2010, In: EMBO Journal. 29 , p. 3967-3978 12 p.

PHF8 targets histone methylation and RNA polymerase II to activate transcription

Fortschegger K., de Graaf P., Outchkourov N.S., van Schaik F.M.A., Timmers H.T.M., Shiekhattar R. 2010, In: Molecular and Cellular Biology. 13 , p. 3286-3298 13 p.

Chromatin interaction of TATA-binding protein (TBP) is dynamically regulated in human cells

de Graaf P., Mousson F., Geverts B., Scheer E., Tora L., Houtsmuller A., Timmers H.T.M. 2010, In: Journal of Cell Science. 123 , p. 2663-2671 9 p.

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AFAS, Lehmann WD, Jochemsen AG, Shiloh Y 5 Apr 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102 , p. 5056-5061 6 p.

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