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prof. dr. ir. H.M. (Hester) den Ruijter

prof. dr. ir. H.M. (Hester) den Ruijter

Full Professor
prof. dr. ir. H.M. (Hester) den Ruijter
  • Department of Experimental Cardiology

Research Programs

Circulatory Health

Biography

Biography

Welcome to my page. Let me introduce myself, I am Hester den Ruijter, Professor of Cardiovascular disease in women. My aim is to translate knowledge from experimental research to the patient. In women, the diagnosis of heart disease is a problem. Most available diagnostics for heart disease have been tested in men and directly translated to women. Nowadays we are increasingly becoming aware that male-derived tests do not always detect heart disease in women. There are interesting sex differences in the pathophysiology of heart disease that may explain why diagnostic tests developed in men fail to detect heart disease in women. Therefore, my goal is to obtain novel biomarkers that facilitate the diagnosis of heart disease in women. If you have any questions regarding my research, you are welcome to contact me.

Side Activities

  • Member of Dekker committee, Dutch Heart Foundation

    1 Jan 2022 → 1 Jan 2025

  • Edit

    Research Council Member, Swiss National Science Foundation SNF

    1 Jan 2022 → 1 Jan 2023

  • Edit

    Committee member Klinische Fellows, ZonMw

    1 Jan 2022 → 1 Jan 2027

  • Edit

    Supervisory committee member , Stichting LEEFH

    1 Jun 2021 → …

  • Edit

    Committee member , Health Holland

    1 Jun 2020 → 1 Jun 2025

Fellowship and Awards

Agnites Vrolikprijs award for research impact UU (2019)

AHA Scott Grundy Award for Excellence in Metabolism Research (2010)

Research Output (230)

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Mekke Joost M, Sakkers Tim R, Verwer Maarten C, van den Dungen Noortje A M, Song Yipei, Miller Clint L, Finn Aloke V, Pasterkamp Gerard, Mokry Michal, den Ruijter Hester M, Vink Aryan, de Kleijn Dominique P V, de Borst Gert J, Haitjema Saskia, van der Laan Sander W Dec 2023, In: Scientific Reports. 13 15 p.

Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis

Buono Michele F, Benavente Ernest Diez, Slenders Lotte, Methorst Daisey, Tessels Daniëlle, Mili Eloi, Finger Roxy, Kapteijn Daniek, Daniels Mark, van den Dungen Noortje A M, Calis Jorg J A, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Pasterkamp Gerard, den Ruijter Hester M, Mokry Michal 27 Oct 2023, In: Journal of the American Heart Association. 12

Sex differences in the genetic and molecular mechanisms of coronary artery disease

Sakkers Tim R, Mokry Michal, Civelek Mete, Erdmann Jeanette, Pasterkamp Gerard, Diez Benavente Ernest, den Ruijter Hester M 5 Oct 2023, In: Atherosclerosis. 384

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Kavousi Maryam et al. 28 Sep 2023, In: Nature Genetics. 55 , p. 1651-1664 14 p.

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques

Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Björkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 17 Aug 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 1836-1850 15 p.

X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

Buono Michele F, Benavente Ernest Diez, Daniels Mark, Mol Barend M, Mekke Joost M, de Borst Gert J, de Kleijn Dominique P V, van der Laan Sander W, Pasterkamp Gerard, Onland-Moret Charlotte, Mokry Michal, den Ruijter Hester M 5 Jul 2023, In: Biology of Sex Differences. 14 12 p.

Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling

van Ommen Anne-Mar, Diez Benavente Ernest, Onland-Moret N Charlotte, Valstar Gideon B, Cramer Maarten J, Rutten Frans H, Teske Arco J, Menken Roxana, Hofstra Leonard, Tulevski Igor I, Sweitzer Nancy, Somsen G Aernout, den Ruijter Hester M 29 Jun 2023, In: Circulation. Heart Failure. 16 , p. 615-629 15 p.

Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients

Lu Chang, Donners Marjo M P C, Karel Joël, de Boer Hetty, van Zonneveld Anton Jan, den Ruijter Hester, Jukema J Wouter, Kraaijeveld Adriaan, Kuiper Johan, Pasterkamp Gerard, Cavill Rachel, Perales-Patón Javier, Ferrannini Ele, Goossens Pieter, Biessen Erik A L 14 Apr 2023, In: Atherosclerosis. 384 10 p.

Sex-specific Mendelian randomisation to assess the causality of sex differences in the effects of risk factors and treatment:spotlight on hypertension

de Ruiter Sophie C, Schmidt A Floriaan, Grobbee Diederick E, den Ruijter Hester M, Peters Sanne A E 7 Apr 2023, In: Journal of human hypertension. 37 , p. 602-608 7 p.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Bj Rkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 9 Feb 2023,

All research output

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