prof. dr. R.M. (Rick) Dijkhuizen

prof. dr. R.M. (Rick) Dijkhuizen

Full Professor
prof. dr. R.M. (Rick) Dijkhuizen
  • Biomedical MR Imaging and Spectroscopy Group

Research Programs



Rick Dijkhuizen received his Ph.D. at Utrecht University in 1998 (thesis title: 'Magnetic Resonance Imaging and Spectroscopy in Experimental Cerebral Ischemia'). From 1999 until 2002 he worked at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School (Charlestown/Boston, MA, USA), first as Postdoctoral Fellow and later as Instructor. There his research focused on elucidating spontaneous and therapy-induced recovery after cerebrovascular injury (e.g. stroke) with different MRI techniques in patients and experimental models. In 2002 he became head of the Biomedical MR Imaging and Spectroscopy group, part of the Center for Image Sciences, at the University Medical Center Utrecht. He was a Visiting Associate Professor at the Department of Radiology at Stanford University School of Medicine from 2013 until 2014.

His current research interests include multiparametric imaging of brain structure and function in health and disease, with a particular focus on i) development of tools for improved diagnosis of brain pathophysiology, ii) characterization of neural network (re)organization, and iii) monitoring of neuroprotective and -restorative therapies. He has recently initiated a translational research project that aims to establish safe and effective modulation of neural networks to enhance functional recovery after stroke through non-invasive brain stimulation in stroke animal models and patients.

He has teamed up with different colleagues of the UMCU Brain Center for preclinical imaging studies on brain disorders, and he collaborates with various national and international institutions on topics such as brain plasticity and molecular imaging. Rick Dijkhuizen has been workpackage leader in two EU-FP7 research programs (EUSTROKE and TACTICS). He served/serves on the Board of Directors of the International Society for Cerebral Blood Flow and Metabolism, and the Editorial Boards of the Journal of Cerebral Blood Flow and Metabolism, Translational Stroke Research, and Stroke. He is Associate Editor of Frontiers in Neurology|Stroke and the Journal of Cerebral Blood Flow and Metabolism.

Research line

Experimental and Translational Neuroimaging

Most recent key publications

1: Otte WM, van der Marel K, van Meer MP, van Rijen PC, Gosselaar PH, Braun KP, Dijkhuizen RM. Altered contralateral sensorimotor system organization after experimental hemispherectomy: a structural and functional connectivity study. J Cereb Blood Flow Metab. 2015;35:1358-67.
2: Dijkhuizen RM, Zaharchuk G, Otte WM. Assessment and modulation of resting-state neural networks after stroke. Curr Opin Neurol. 2014;27:637-43.
3: Dijkhuizen RM. Imaging neuronal loss and recovery in compromised but viable brain tissue. Brain. 2013;136:1689-91.
4: van Meer MP, Otte WM, van der Marel K, Nijboer CH, Kavelaars A, van der Sprenkel JW, Viergever MA, Dijkhuizen RM. Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J Neurosci. 2012;32:4495-507.
5: Schaechter JD, van Oers CA, Groisser BN, Salles SS, Vangel MG, Moore CI, Dijkhuizen RM. Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients. Neurorehabil Neural Repair. 2012;26:325-34.

Side Activities

Member of the Editorial Board of Translational Stroke Research

Member of the Editorial Board of Stroke

Associate Editor of Frontiers in Neurology|Stroke

Associate Editor of the Journal for Cerebral Blood Flow and Metabolism

Chair of the Netherlands Experimental Stroke Alliance

Fellowship and Awards

VICI award, Netherlands Organization for Scientific Research (2013)

‘High Potential’ award, Utrecht University (2007)

VIDI award, Netherlands Organization for Scientific Research (2006)

Royal Netherlands Academy of Arts and Sciences (KNAW) Fellowship (2002)

Postdoctoral Fellowship Award (New England Affiliate), American Heart Association (2000)

Talent Fellowship Award, Netherlands Organization for Scientific Research (1998)

Research Output (186)

Continuous Theta-Burst Stimulation of the Contralesional Primary Motor Cortex for Promotion of Upper Limb Recovery After Stroke:A Randomized Controlled Trial

Vink Jord J.T., van Lieshout Eline C.C., Otte Willem M., van Eijk Ruben P.A., Kouwenhoven Mirjam, Neggers Sebastiaan F.W., van der Worp H. Bart, Visser-Meily Johanna M.A., Dijkhuizen Rick M. 1 Aug 2023, In: Stroke. 54 , p. 1962-1971 10 p.

A consensus protocol for functional connectivity analysis in the rat brain

Grandjean Joanes et al. Apr 2023, In: Nature Neuroscience. 26 , p. 673-681 9 p.

Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

Wielenga Vera H., Dijkhuizen Rick M., Van der Toorn Annette 31 Jan 2023, p. 153-168 16 p.

Cerebral blood flow quantification with multi-delay arterial spin labeling in ischemic stroke and the association with early neurological outcome

Luijten Sven P.R., Bos Daniel, van Doormaal Pieter Jan, Goyal Mayank, Dijkhuizen Rick M., Dippel Diederik W.J., Roozenbeek Bob, van der Lugt Aad, Warnert Esther A.H. 2023, In: NeuroImage: Clinical. 37 , p. 1-8

In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Meerwaldt Anu E., Straathof Milou, Oosterveld Wija, van Heijningen Caroline L., van Leent Mandy M.T., Toner Yohana C., Munitz Jazz, Teunissen Abraham J.P., Daemen Charlotte C., van der Toorn Annette, van Vliet Gerard, van Tilborg Geralda A.F., De Feyter Henk M., de Graaf Robin A., Hol Elly M., Mulder Willem J.M., Dijkhuizen Rick M. 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43 , p. 778-790 13 p.

Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., Smeele Christel E., van Heijningen Caroline, van der Toorn Annette, Buitelaar Jan, Glennon Jeffrey, Otte Willem M., Dijkhuizen Rick, Buitelaar Jan, de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey, van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Natalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy Declan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Dijkhuizen Rick, Blezer Erwin L.A., Straathof Milou, Mol Wouter, Otte Willem, Durston Sarah, Mensen Vincent, Oranje Bob, Mandl René, Aug 2022, In: Psychopharmacology. 239 , p. 2457-2470 14 p.

Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities

Candelario-Jalil Eduardo, Dijkhuizen Rick M., Magnus Tim 1 May 2022, In: Stroke. 53 , p. 1473-1486 14 p.

Comparison of Large Animal Models for Acute Ischemic Stroke:Which Model to Use?

Taha Aladdin, Bobi Joaquim, Dammers Ruben, Dijkhuizen Rick M., Dreyer Antje Y., Van Es Adriaan C.G.M., Ferrara Fabienne, Gounis Matthew J., Nitzsche Björn, Platt Simon, Stoffel Michael H., Volovici Victor, Del Zoppo Gregory J., Duncker Dirk J., Dippel Diederik W.J., Boltze Johannes, Van Beusekom Heleen M.M. 1 Apr 2022, In: Stroke. 53 , p. 1411-1422 12 p.

VWF-targeted thrombolysis to overcome rh-tPA resistance in experimental murine ischemic stroke models

van Moorsel Marc V.A., de Maat Steven, Vercruysse Kristof, van Leeuwen Esther M., Jacqmarcq Charlène, Bonnard Thomas, Vivien Denis, van der Worp H. Bart, Dijkhuizen Rick M., Maas Coen 2022, In: Blood. 140 , p. 2844-2848 5 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not