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dr. S.G. (Sjoerd) Elias

Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Cancer
  • Julius Center Research Program Cancer

dr. S.G. (Sjoerd) Elias

Research Programs

Biography

I obtained my MSc in Clinical Epidemiology (2002) at the Netherlands Institute for Health Sciences, and my PhD at Utrecht University (2003). Following graduation from Medical School in 2005 I worked as a resident in radiology (Gelre Ziekenhuizen Apeldoorn, the Netherlands, 2006-2007). A personal Dutch Cancer Society Research Fellowship (2009-2013) enabled me to work as a visiting scientist at the Molecular Imaging Program at Stanford (professor SS Gambhir), the Department of Radiology and Biomedical Imaging at the University of California San Francisco (professor NM Hylton), and the Department of Molecular Pathology at the Netherlands Cancer Institute (professor LJ van't Veer). Since 2008, I work as a Clinical Epidemiologist in the research programs Cancer and Methodology at the Julius Center for Health Sciences and Primary Care, since 2018 as Associate Professor. Furthermore, I have more than ten years of experience in teaching and coordinating courses in clinical epidemiology, both nationally as well as internationally. Since 2020 I am coordinator of the PhD program Clinical and Translational Oncology.

Interests and Focus

My main research focus is on the clinical evaluation and translation of biomarkers, particularly for cancer classification (i.e. diagnostic, prognostic, and predictive markers). These markers include emerging imaging technologies such as molecular imaging, omics-based tests, and organoids. I have both experience in preclinical research as well as applied clinical science, and have expertise and experience in the design and analysis of studies spanning all (translation) phases of biomarker development, as well as treatment studies (from phase I through phase III).

Side Activities

  • - Coordinator of the PhD program Clinical and Translational Oncology.

    - Coordinator of the SUMMA course "Wetenschappelijke Vorming - Onderzoeksmethodologie" ("applied clinical research").

    - Coordinator of the MSc Epidemiology course "Advanced Topics in Causal Research: Confounding and Effect-Modification".

    - Member of the Internal Review Committee Exploration of the Dutch Cancer Society.

    - Member of the Dutch Association for Epidemiology (Vereniging voor Epidemiologie), Registration as Senior Epidemiologist (B) (SMBWO, 2006).

Fellowship and Awards

  • 2016-2017: Jury member of the Talma Eykman award, UMC Utrecht.

    2016-2017: Jury member of the Frits de Waard Penning, UMC Utrecht.

    2014: Epidemiology teacher of the year, Epidemiology department, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht.

    2014: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University.

    2013-2016: Methodologist of the Medical Ethical Review Board of the UMC Utrecht.

    2013: UMC Utrecht Research Talent Program.

    2012: Invitee, 2nd Inspire2Live annual conference at the Royal Netherlands Academy of Arts and Sciences (meeting of talented young international cancer scientists).

    2011: René Vogels Foundation travel grant.

    2009: Dutch Cancer Society Research Fellowship (four year personal grant).

Research Output (145)

Systematic review and external validation of prediction models based on symptoms and biomarkers for identifying endoscopic activity in Crohn's disease

Brand Eelco C, Elias Sjoerd G, Minderhoud Itta M, van der Veen Julius J, Baert Filip J, Laharie David, Bossuyt Peter, Bouhnik Yoram, Buisson Anthony, Lambrecht Guy, Louis Edouard, Pariente Benjamin, Pierik Marieke J, van der Woude C Janneke, D'Haens Geert R A M, Vermeire Séverine, Oldenburg Bas, 1 jul 2020, In: Clinical Gastroenterology and Hepatology. 18 , p. 1704-1718 15 p.

[Zr-89]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer

van Helden E J, Elias S G, Gerritse S L, van Es S C, Boon E, Huisman M C, van Grieken N C T, Dekker H, van Dongen G A M S, Vugts D J, Boellaard R, van Herpen C M L, de Vries E G E, Oyen W J G, Brouwers A H, Verheul H M W, Hoekstra O S, Menke-van der Houven van Oordt C W apr 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47 , p. 849-859 11 p.

Tumor Seeding During Colonoscopy as a Possible Cause for Metachronous Colorectal Cancer

Backes Yara, Seerden Tom C.J., van Gestel Rosanne S.F.E., Kranenburg Onno, Ubink Inge, Schiffelers Raymond M., van Straten Demian, van der Capellen Malu S., van de Weerd Simone, de Leng Wendy W.J., Siersema Peter D., Offerhaus G. Johan A., Morsink Folkert H., Ramphal Winesh, Terhaar Sive Droste Jochiim, van Lent Anja U.G., Geesing Joost M.J., Vleggaar Frank P., Elias Sjoerd G., Lacle Miangela M., Moons Leon M.G. 1 nov 2019, In: Gastroenterology. 157 , p. 1222-1232.e4

First evidence for a dose-response relationship in patients treated with 166Ho-radioembolization:a prospective study

Bastiaannet Remco, van Roekel Caren, Smits Maarten L J, Elias Sjoerd G, van Amsterdam Wouter A C, Doan Dan T, Prince Jip F, Bruijnen Rutger C G, de Jong Hugo W A M, Lam Marnix G E H 10 okt 2019, In: Journal of Nuclear Medicine. 61 , p. 608-612 5 p.

Choosing the right strategy based on individualized treatment effect predictions: Combination versus sequential chemotherapy in patients with metastatic colorectal cancer

Koopman M., Kwakman J. J., van Kruijsdijk R. C. M., Elias S. G., Seymour M. T., Meade A. M., Visseren F., Punt C. J. A. okt 2019, In: Annals of Oncology. 30

The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer

van Steenhoven J E C, Kuijer A, Schreuder K, Elias S G, van Diest P J, van der Wall E, Siesling S, van Dalen T okt 2019, In: Annals of Surgical Oncology. 26 , p. 3495-3501 7 p.

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

Ubink I., Bolhaqueiro A. C. F., Elias S. G., Raats D. A. E., Constantinides A., Peters N. A., Wassenaar E. C. E., de Hingh I. H. J. T., Rovers K. P., van Grevenstein W. M. U., Lacle M. M., Kops G. J. P. L., Rinkes I. H. M. Borel, Kranenburg O. sep 2019, In: British Journal of Surgery. 106 , p. 1404-1414 11 p.

Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma

Verhoeff Sarah R, van Es Suzanne C, Boon Eline, van Helden Erik, Angus Lindsay, Elias Sjoerd G, Oosting Sjoukje F, Aarntzen Erik H, Brouwers Adrienne H, Kwee Thomas C, Heskamp Sandra, Hoekstra Otto S, Verheul Henk, van der Veldt Astrid A M, de Vries Elisabeth G E, Boerman Otto C, van der Graaf Winette T A, Oyen Wim J G, van Herpen Carla M L 1 aug 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46 , p. 1931-1939 9 p.

PREDICTION OF ENDOSCOPIC ACTIVITY IN PATIENTS WITH CROHN'S DISEASE - SYSTEMATIC REVIEW AND EXTERNAL VALIDATION OF PUBLISHED PREDICTION MODELS

Brand Eelco C., Elias Sjoerd G., Minderhoud Itta M., van der Veen Julius J., Baert Filip J., Laharie David, Bossuyt Peter, Bouhnik Yoram, Buisson Anthony, Lambrecht Guy, Louis Edouard, Pariente Benjamin, Pierik Marie, Van Der Woude Christien Janneke, D'Haens Geert R., Vermeire Severine, Oldenburg Bas mei 2019, In: Gastroenterology. 156 , p. S848-S848

Prediction of endoscopic activity in patients with Crohn's disease: systematic review and external validation of published prediction models

Brand E. C., Elias S. G., Minderhoud I. M., van der Veen J. J., Baert F., Laharie D., Bossuyt P., Bouhnik Y., Buisson A., Lambrecht G., Louis E., Pariente B., Pierik M. J., van der Woude C. J., D'Haens G. R., Vermeire S., Oldenburg B. mrt 2019, In: Journal of Crohn's & Colitis. 13 , p. S338-S339

All Research Output (145)