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dr. M. (Magdalena) Harakalová

dr. M. (Magdalena) Harakalová

Assistant Professor
dr. M. (Magdalena) Harakalová
  • Onderzoek Precision medicine

Research Programs

Circulatory Health

Biography

Biography

I am an Assistant Professor at the Department of Cardiology and the Regenerative Medicine Utrecht (RMU) center at UMCU. As a principal investigator, I am leading an independent research line that is based on a clear need from clinics: the identification of molecular mechanisms in carriers of genetic mutations who are at risk of developing genetic cardiomyopathies. My overarching research question is: Why is DNA not the heart’s destiny? - I study the chronological effects of a DNA mutation on the level of DNA/chromatin/RNA/protein but also cellular organelles, whole cells, tissue and the human organism. I aim to redefine cardiomyopathies on a personalized level and design diagnostic, preventive, and treatment strategies with the ultimate goal to timely predict and eradicate them. I use human cardiac tissue and patient-derived human iPSC-cardiomyocyte (hiPSC-CMs) models to investigate cardiomyopathy heterogeneity through next-generation sequencing-based -omics techniques, bioinformatics, high-resolution imaging, and functional studies. I have a medical background but I decided to work as a full-time scientist because I felt that progress made in fundamental research does not reach clinics fast enough.

Research Output (67)

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes

Yuan Qianliang, Maas Renee G.C., Brouwer Ellen C.J., Pei Jiayi, Blok Christian Snijders, Popovic Marko A., Paauw Nanne J., Bovenschen Niels, Hjortnaes Jesper, Harakalova Magdalena, Doevendans Pieter A., Sluijter Joost P.G., van der Velden Jolanda, Buikema Jan W. Feb 2022, In: Journal of Cardiovascular Development and Disease. 9 , p. 1-13

Chromatin Immunoprecipitation Sequencing (ChIP-seq) Protocol for Small Amounts of Frozen Biobanked Cardiac Tissue

Pei Jiayi, van den Dungen Noortje A M, Asselbergs Folkert W, Mokry Michal, Harakalova Magdalena 2022, 2458 , p. 97-111 15 p.

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20

Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers

van Driel Beau Olivier, Schuldt Maike, Algül Sila, Levin Evgeni, Güclü Ahmet, Germans Tjeerd, Rossum Albert C van, Pei Jiayi, Harakalova Magdalena, Baas Annette, Jans Judith J M, van der Velden Jolanda 30 Mar 2021, In: International journal of molecular sciences. 22 , p. 1-18

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Maas Renee G.C., Lee Soah, Harakalova Magdalena, Snijders Blok Christian J.B., Goodyer William R., Hjortnaes Jesper, Doevendans Pieter A.F.M., Van Laake Linda W., van der Velden Jolanda, Asselbergs Folkert W., Wu Joseph C., Sluijter Joost P.G., Wu Sean M., Buikema Jan W. 19 Mar 2021, In: STAR protocols. 2

P62-positive aggregates are homogenously distributed in the myocardium and associated with the type of mutation in genetic cardiomyopathy

van der Klooster Zoë Joy, Sepehrkhouy Shahrzad, Dooijes Dennis, Te Rijdt Wouter P, Schuiringa Frederique S A M, Lingeman Jolanthe, van Tintelen Johannes Peter, Harakalova Magdalena, Goldschmeding Roel, Suurmeijer Albert J H, Asselbergs Folkert W, Vink Aryan 18 Feb 2021, In: Journal of Cellular and Molecular Medicine. 25 , p. 3160-3166 7 p.

Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy

Feyen Dries A.M., Perea-Gil Isaac, Maas Renee G.C., Harakalova Magdalena, Gavidia Alexandra A., Arthur Ataam Jennifer, Wu Ting Hsuan, Vink Aryan, Pei Jiayi, Vadgama Nirmal, Suurmeijer Albert J., Te Rijdt Wouter P., Vu Michelle, Amatya Prashila L., Prado Maricela, Zhang Yuan, Dunkenberger Logan, Sluijter Joost P.G., Sallam Karim, Asselbergs Folkert W., Mercola Mark, Karakikes Ioannis 2021, In: Circulation. 144 , p. 382-392 11 p.

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

Schuldt Maike, Pei Jiayi, Harakalova Magdalena, Dorsch Larissa M, Schlossarek Saskia, Mokry Michal, Knol Jaco C, Pham Thang V, Schelfhorst Tim, Piersma Sander R, Dos Remedios Cris, Dalinghaus Michiel, Michels Michelle, Asselbergs Folkert W, Moutin Marie-Jo, Carrier Lucie, Jimenez Connie R, van der Velden Jolanda, Kuster Diederik W D 2021, In: Circulation. Heart Failure. 14 , p. 39-55

Strength of patient cohorts and biobanks for cardiomyopathy research

de Boer R. A., Nijenkamp L. L.A.M., Silljé H. H.W., Eijgenraam T. R., Parbhudayal R., van Driel B., Huurman R., Michels M., Pei J., Harakalova M., van Lint F. H.M., Jansen M., Baas A. F., Asselbergs F. W., van Tintelen J. P., Brundel B. J.J.M., Dorsch L. M., Schuldt M., Kuster D. W.D., van der Velden J., 1 Aug 2020, In: Netherlands Heart Journal. 28 , p. 50-56 7 p.

All research output

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