dr. M. (Magdalena) Harakalová
dr. M. (Magdalena) Harakalová
- Onderzoek Precision medicine
Research Programs
Biography
Biography
I am an Assistant Professor at the Department of Cardiology and the Regenerative Medicine Utrecht (RMU) center at UMCU. As a principal investigator, I am leading an independent research line that is based on a clear need from clinics: the identification of molecular mechanisms in carriers of genetic mutations who are at risk of developing genetic cardiomyopathies. My overarching research question is: Why is DNA not the heart’s destiny? - I study the chronological effects of a DNA mutation on the level of DNA/chromatin/RNA/protein but also cellular organelles, whole cells, tissue and the human organism. I aim to redefine cardiomyopathies on a personalized level and design diagnostic, preventive, and treatment strategies with the ultimate goal to timely predict and eradicate them. I use human cardiac tissue and patient-derived human iPSC-cardiomyocyte (hiPSC-CMs) models to investigate cardiomyopathy heterogeneity through next-generation sequencing-based -omics techniques, bioinformatics, high-resolution imaging, and functional studies. I have a medical background but I decided to work as a full-time scientist because I felt that progress made in fundamental research does not reach clinics fast enough.
Research Output (69)
Gaar-Humphreys Karen R, Spanjersberg Talitha C F, Santarelli Giorgia, Grinwis Guy C M, Szatmári Viktor, Roelen Bernard A J, Vink Aryan, van Tintelen J Peter, Asselbergs Folkert W, Fieten Hille, Harakalova Magdalena, van Steenbeek Frank G 1 Jul 2022, In: Animals : an open access journal from MDPI. 12 , p. 1-18
Mittal Nishka, Dave Jaydev, Harakalova Magdalena, van Tintelen J. Peter, Asselbergs Folkert W., Doevendans Pieter A., Costa Kevin D., Turnbull Irene C., Stillitano Francesca Apr 2022, In: Stem Cell Research. 60 , p. 1-5
Yuan Qianliang, Maas Renee G.C., Brouwer Ellen C.J., Pei Jiayi, Blok Christian Snijders, Popovic Marko A., Paauw Nanne J., Bovenschen Niels, Hjortnaes Jesper, Harakalova Magdalena, Doevendans Pieter A., Sluijter Joost P.G., van der Velden Jolanda, Buikema Jan W. Feb 2022, In: Journal of Cardiovascular Development and Disease. 9 , p. 1-13
Pei Jiayi, van den Dungen Noortje A M, Asselbergs Folkert W, Mokry Michal, Harakalova Magdalena 2022, 2458 , p. 97-111 15 p.
Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20
van Driel Beau Olivier, Schuldt Maike, Algül Sila, Levin Evgeni, Güclü Ahmet, Germans Tjeerd, Rossum Albert C van, Pei Jiayi, Harakalova Magdalena, Baas Annette, Jans Judith J M, van der Velden Jolanda 30 Mar 2021, In: International journal of molecular sciences. 22 , p. 1-18
Maas Renee G.C., Lee Soah, Harakalova Magdalena, Snijders Blok Christian J.B., Goodyer William R., Hjortnaes Jesper, Doevendans Pieter A.F.M., Van Laake Linda W., van der Velden Jolanda, Asselbergs Folkert W., Wu Joseph C., Sluijter Joost P.G., Wu Sean M., Buikema Jan W. 19 Mar 2021, In: STAR protocols. 2
Garnier Sophie et al. 3 Mar 2021, In: European heart journal. 42 , p. 2000-2011 12 p.
van der Klooster Zoë Joy, Sepehrkhouy Shahrzad, Dooijes Dennis, Te Rijdt Wouter P, Schuiringa Frederique S A M, Lingeman Jolanthe, van Tintelen Johannes Peter, Harakalova Magdalena, Goldschmeding Roel, Suurmeijer Albert J H, Asselbergs Folkert W, Vink Aryan 18 Feb 2021, In: Journal of Cellular and Molecular Medicine. 25 , p. 3160-3166 7 p.
Feyen Dries A.M., Perea-Gil Isaac, Maas Renee G.C., Harakalova Magdalena, Gavidia Alexandra A., Arthur Ataam Jennifer, Wu Ting Hsuan, Vink Aryan, Pei Jiayi, Vadgama Nirmal, Suurmeijer Albert J., Te Rijdt Wouter P., Vu Michelle, Amatya Prashila L., Prado Maricela, Zhang Yuan, Dunkenberger Logan, Sluijter Joost P.G., Sallam Karim, Asselbergs Folkert W., Mercola Mark, Karakikes Ioannis 2021, In: Circulation. 144 , p. 382-392 11 p.