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prof. dr. O.W. Kranenburg

prof. dr. O.W. Kranenburg

Full Professor

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Research Output (134)

Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

Poghosyan Susanna, Frenkel Nicola, Lentzas Aristeidis, Laoukili Jamila, Rinkes Inne Borel, Kranenburg Onno, Hagendoorn Jeroen 1 Feb 2022, In: Cancers. 14 , p. 1-18

Mismatch repair status in patient‐derived colorectal cancer organoids does not affect intrinsic tumor cell sensitivity to systemic therapy

Küçükköse Emre, Wensink G. Emerens, Roelse Celine M., van Schelven Susanne J., Raats Daniëlle A.E., Boj Sylvia F., Koopman Miriam, Laoukili Jamila, Roodhart Jeanine M.L., Kranenburg Onno 1 Nov 2021, In: Cancers. 13 , p. 1-12

Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases:A Phase 2 Randomized Clinical Trial

Rovers Koen P., Bakkers Checca, Nienhuijs Simon W., Burger Jacobus W.A., Creemers Geert Jan M., Thijs Anna M.J., Brandt-Kerkhof Alexandra R.M., Madsen Eva V.E., Van Meerten Esther, Tuynman Jurriaan B., Kusters Miranda, Versteeg Kathelijn S., Aalbers Arend G.J., Kok Niels F.M., Buffart Tineke E., Wiezer Marinus J., Boerma Djamila, Los Maartje, De Reuver Philip R., Bremers Andreas J.A., Verheul Henk M.W., Kruijff Schelto, De Groot Derk Jan A., Witkamp Arjen J., Van Grevenstein Wilhelmina M.U., Koopman Miriam, Nederend Joost, Lahaye Max J., Kranenburg Onno, Fijneman Remond J.A., Van 'T Erve Iris, Snaebjornsson Petur, Hemmer Patrick H.J., Dijkgraaf Marcel G.W., Punt Cornelis J.A., Tanis Pieter J., De Hingh Ignace H.J.T. Aug 2021, In: JAMA Surgery. 156 , p. 710-720 11 p.

Long-lived human lymphatic endothelial cells to study lymphatic biology and lymphatic vessel/tumor coculture in a 3D microfluidic model

Frenkel Nicola, Poghosyan Susanna, Alarcón Carmen Rubio, García Silvia Bonilla, Queiroz Karla, Van Den Bent Lotte, Laoukili Jamila, Rinkes Inne Borel, Vulto Paul, Kranenburg Onno, Hagendoorn Jeroen 12 Jul 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 3030-3042 13 p.

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

Sacchetti Andrea, Teeuwssen Miriam, Verhagen Mathijs, Joosten Rosalie, Xu Tong, Stabile Roberto, van der Steen Berdine, Watson Martin M., Gusinac Alem, Kim Won Kyu, Ubink Inge, Van de Werken Harmen J.G., Fumagalli Arianna, Paauwe Madelon, Van Rheenen Jacco, Sansom Owen J., Kranenburg Onno, Fodde Riccardo 26 May 2021, In: eLife. 10 , p. 1-28

A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity

Wenmaekers Stijn, Viergever Bastiaan J., Kumar Gunjan, Kranenburg Onno, Black Peter C., Daugaard Mads, Meijer Richard P. 20 May 2021, In: Cells. 10 19 p.

Specialized nutrition improves muscle function and physical activity without affecting chemotherapy efficacy in C26 tumour-bearing mice

Wijler Liza A, Raats Danielle A E, Elias Sjoerd G, Dijk Francina J, Quirindongo Hanil, May Anne M, Furber Matthew J W, Dorresteijn Bram, van Dijk Miriam, Kranenburg Onno 6 May 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12 , p. 796-810 15 p.

Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid

van't Erve Iris, Rovers Koen P., Constantinides Alexander, Bolhuis Karen, Wassenaar Emma C.E., Lurvink Robin J., Huysentruyt Clément J., Snaebjornsson Petur, Boerma Djamila, van den Broek Daan, Buffart Tineke E., Lahaye Max J., Aalbers Arend G.J., Kok Niels F.M., Meijer Gerrit A., Punt Cornelis J.A., Kranenburg Onno, de Hingh Ignace H.J.T., Fijneman Remond J.A. May 2021, In: Journal of Pathology: Clinical Research. 7 , p. 203-208 6 p.

Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

Wensink G Emerens, Elias Sjoerd G, Mullenders Jasper, Koopman Miriam, Boj Sylvia F, Kranenburg Onno W, Roodhart Jeanine M L 12 Apr 2021, In: NPJ precision oncology. 5

A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research

Wensink Emerens, Bond Marinde, Kucukkose Emre, May Anne, Vink Geraldine, Koopman Miriam, Kranenburg Onno, Roodhart Jeanine Apr 2021, In: Cancer Treatment Reviews. 95 12 p.

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