prof. dr. J.H.E. Kuball

prof. dr. J.H.E. Kuball

Full Professor
prof. dr. J.H.E. Kuball
  • Center for Translational Immunology (CTI) Research
  • Department of Hematology



Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

Side Activities

Board activities

  • EBMT Chair Legal and Regulatory Affairs Committee 2019-
  • HOVON General board 2014-
  • KWF PPS commissie 2022-
  • KWF adviesraad  2016-2022
  • Wetenschappelijke raad KIKA 2018-2021

Translational Valorisation

  • Cofounder and shareholder of Gadeta  2015-
  • Patent holder on multipe inventions  licensed to Gadeta and Miltenyi Biotech  2012-
  • Receiving revenues from licensed patents in the field of genetic engineering 2021-


  • ASH
  • EBMT
  • EHA Member
  • HOVON Leukemia working party
  • HOVON SCT working party 

External positions

  • Scientific advisor, GADETA, 2018 → 2020
  • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
  • Scientific cofounder and CSO, GADETA, 2015 → 2018
  • Shareholder, GADETA, 2015 → …
  • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
  • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)

Research Output (196)

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Huyveneers Laura E.P., Bruns Anke, Stam Arjen, Ellerbroek Pauline, de Jong Dorien, Nagy Noémi A., Gumbs Stephanie B.H., Tesselaar Kiki, Bosman Kobus, Salgado Maria, Hütter Gero, Brosens Lodewijk A.A., Kwon Mi, Diez Martin Jose, van der Meer Jan T.M., de Kort Theun M., Sáez-Cirión Asier, Schulze zur Wiesch Julian, Boelens Jaap Jan, Martinez-Picado Javier, Kuball Jürgen H.E., Wensing Annemarie M.J., Nijhuis Monique, 17 Sep 2022, In: Viruses. 14

Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia:A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Ruggeri Annalisa, Galimard Jacques-Emmanuel, Labopin Myriam, Rafii Hanadi, Blaise Didier, Ciceri Fabio, Diez-Martin Jose-Luiz, Cornelissen Jan, Chevallier Patrice, Sanchez-Guijo Fermin, Nicholson Emma, Castagna Luca, Forcade Edouard, Kuball Jürgen, Rovira Montserrat, Koc Yener, Pavlu Jiri, Gulbas Zafar, Vydra Jan, Baron Frederic, Sanz Jaime, Spyridonidis Alexandros, Savani Bipin, Gluckman Eliane, Nagler Arnon, Mohty Mohamad 10 Jul 2022, In: Transplantation and Cellular Therapy. 28 , p. 710.e1-710.e10

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults

Vyborova Anna, Janssen Anke, Gatti Lucrezia, Karaiskaki Froso, Yonika Austin, van Dooremalen Sanne, Sanders Jasper, Beringer Dennis X, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 7 Jul 2022, In: Frontiers in Immunology. 13 , p. 1-13

Outcome of allogeneic haematopoietic cell transplantation in eosinophilic disorders:A retrospective study by the chronic malignancies working party of the EBMT

McLornan Donal P, Gras Luuk, Martin Ivonne, Sirait Tiarlan, Schroeder Thomas, Blau Igor Wolfgang, Kuball Jürgen, Byrne Jenny, Collin Matthew, Stadler Michael, Desmier Déborah, Salmenniemi Urpu, Jindra Pavel, Mikhailova Natalia, Lenhoff Stig, Rifón Jose, Robin Marie, Rovira Montserrat, Veelken Hendrik, Sadowska-Klasa Alicja, Zecca Marco, Hayden Patrick J, Czerw Tomasz, Hernández-Boluda Juan Carlos, Yakoub-Agha Ibrahim 28 Apr 2022, In: British Journal of Haematology. 198 , p. 209-213 5 p.

Correction to:Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients (Bone Marrow Transplantation, (2021), 56, 12, (2922-2928), 10.1038/s41409-021-01437-0)

Janssen Michelle J.M., Bruns Anke H.W., Verduyn Lunel Frans M., Raijmakers Reinier A.P., de Weijer Roel J., Nanlohy Nening M., Smits Gaby P., van Baarle Debbie, Kuball Jürgen 31 Mar 2022, In: Bone Marrow Transplantation. 57 , p. 1050-1050 1 p.

Posttransplant Cyclophosphamide for Prevention of Graft-versus-Host Disease:results of the prospective randomized HOVON-96 trial

Broers Annoek E C, de Jong Cornelis N, Bakunina Katerina, Hazenberg Mette D, van Marwijk Kooy Marinus, de Groot Marco, van Gelder Michel, Kuball Jürgen, van der Holt Bronno, Meijer Ellen, Cornelissen Jan J 10 Feb 2022, In: Blood Advances. 6 , p. 3378-3385 8 p.

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation:Opportunities and Challenges

Janssen Anke, van Diest Eline, Vyborova Anna, Schrier Lenneke, Bruns Anke, Sebestyen Zsolt, Straetemans Trudy, de Witte Moniek, Kuball Jürgen Jan 2022, In: Viruses. 14 , p. 1-15

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann Tassilo L A, Wouters Anne K, Remst Dennis F G, Hagedoorn Renate S, Meeuwsen Miranda H, van Diest Eline, Leusen Jeanette, Kuball Jürgen, Falkenburg J H Frederik, Heemskerk Mirjam H M 2022, In: OncoImmunology. 11

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

van Diest Eline, Nicolasen Mara J T, Kramer Lovro, Zheng Jiali, Hernández-López Patricia, Beringer Dennis X, Kuball Jürgen 2022, In: Frontiers in Immunology. 13

Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

Cornelissen Loes L, Kreuger Aukje L, Caram-Deelder Camila, Huisman Menno V, Middelburg Rutger A, Kerkhoffs Jean Louis H, von dem Borne Peter A, Beckers Erik A M, de Vooght Karen M K, Kuball Jürgen, van der Bom Johanna G, Zwaginga J J 19 Dec 2021, In: European Journal of Haematology. 108 , p. 310-318 9 p.

All research output

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