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prof. dr. J.H.E. Kuball

Full Professor
prof. dr. J.H.E. Kuball
  • Laboratory for Translational Immunology (LTI)
  • Department of Medical Oncology

Biography

Biography

Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

Side Activities

Board activities

  • EBMT Chair Legal and Regulatory Affairs Committee
  • HOVON General board 
  • KWF adviesraad  
  • Wetenschappelijke raad KIKA 

Translational Valorisation

  •  Cofounder and shareholder of Gadeta      

Memberships

  • ASH
  • CIMT Regulatory Research Group
  • EBMT
  • EHA Member
  • HOVON Leukemia working party
  • HOVON SCT working party 

External positions

  • Scientific advisor, GADETA, 2018 → 2020
  • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
  • Scientific cofounder and CSO, GADETA, 2015 → 2018
  • Shareholder, GADETA, 2015 → …
  • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
  • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)
KWF project Transit (534.100 euro) (2014)

Research Output (163)

αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies

De Witte Moniek A., Janssen Anke, Nijssen Klaartje, Karaiskaki Froso, Swanenberg Luuk, van Rhenen Anna, Admiraal Rick, van der Wagen Lotte, Minnema Monique C., Petersen Eefke, Raymakers Reinier A.P., Westinga Kasper, Straetemans Trudy, Halkes Constantijn J.M., Boelens Jaap Jan, Kuball Jurgen 12 jan 2021, In: Blood Advances. 5 , p. 240-249 10 p.

Editorial: gamma delta T Cells in Cancer:γδ T Cells in Cancer

Coffelt Seth B., Kabelitz Dieter, Silva-Santos Bruno, Kuball Jurgen, Born Willi, Bank Ilan 20 nov 2020, In: Frontiers in Immunology. 11 , p. 1-3

Opportunities and challenges associated with the evaluation of chimeric antigen receptor T cells in real-life

McGrath Eoin, Chabannon Christian, Terwel Sofie, Bonini Chiara, Kuball Jurgen 13 jul 2020, In: Current Opinion in Oncology. 32 , p. 427-433 7 p.

The connected worlds of stem cell transplantation and HIV

Wensing Annemarie M J, Chabannon Christian, Kuball Jurgen 7 jul 2020, In: The lancet. HIV. 7 , p. e594-e595 2 p.

gamma 9 delta 2T cell diversity and the receptor interface with tumor cells

Vyborova Anna, Beringer Dennis X, Fasci Domenico, Karaiskaki Froso, van Diest Eline, Kramer Lovro, de Haas Aram, Sanders Jasper, Janssen Anke, Straetemans Trudy, Olive Daniel, Leusen Jeanette Hw, Boutin Lola, Nedellec Steven, Schwartz Samantha L, Wester Michael J, Lidke Keith A, Scotet Emmanuel, Lidke Diane, Heck Albert Jr, Sebestyen Zsolt, Kuball Jurgen 2 jun 2020, In: Journal of Clinical Investigation. 130 , p. 4637-4651 15 p.

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Eberhard Johanna M., Angin Mathieu, Passaes Caroline, Salgado Maria, Monceaux Valerie, Knops Elena, Kobbe Guido, Jensen Björn, Christopeit Maximilian, Kröger Nicolaus, Vandekerckhove Linos, Badiola Jon, Bandera Alessandra, Raj Kavita, van Lunzen Jan, Hütter Gero, Kuball Jürgen H.E., Martinez-Laperche Carolina, Balsalobre Pascual, Kwon Mi, Díez-Martín José L., Nijhuis Monique, Wensing Annemarie, Martinez-Picado Javier, Schulze Zur Wiesch Julian, Sáez-Cirión Asier 6 mei 2020, In: Science translational medicine. 12 13 p.

Comparison of reduced-intensity conditioning regimens in patients with acute lymphoblastic leukemia >45 years undergoing allogeneic stem cell transplantation-a retrospective study by the Acute Leukemia Working Party of EBMT

Peric Zinaida, Labopin Myriam, Peczynski Christophe, Polge Emmanuelle, Cornelissen Jan, Carpenter Ben, Potter Mike, Malladi Ram, Byrne Jenny, Schouten Harry, Fegueux Nathalie, Socié Gerard, Rovira Montserrat, Kuball Jurgen, Gilleece Maria, Giebel Sebastian, Nagler Arnon, Mohty Mohamad 2 mei 2020, In: Bone Marrow Transplantation. 55 , p. 1560-1569 10 p.

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance

Langenhorst J B, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts A C G, Boelens J J, Huitema A D R, van Maarseveen E M 18 feb 2020, In: British Journal of Clinical Pharmacology. 86 , p. 1499-1509 11 p.

TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Bongiovanni Laura, de Bruin Alain, Beringer Dennis, van Dooremalen Sanne, Shultz Leonard D, Ishikawa Fumihiko, Sebestyen Zsolt, Straetemans Trudy, Kuball Jürgen 5 feb 2020, In: Journal of Leukocyte Biology. 107 , p. 1069-1079 11 p.

gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Janssen Anke, Villacorta Hidalgo José, Beringer Dennis X, van Dooremalen Sanne F.J., Fernando Febilla, van Diest Eline, Terrizzi Antonela R, Bronsert Peter, Kock Sylvia, Schmitt-Graeff Annette, Werner Martin, Heise Kerstin, Follo Marie, Straetemans Trudy, Sebestyen Zsolt, Chudakov Dmitriy M, Kasatskaya Sofya A, Frenkel Felix E, Ravens Sarina, Spierings Eric, Prinz Immo, Küppers Ralf, Malkovsky Miroslav, Fisch Paul, Kuball Jurgen 4 feb 2020, In: Cancer Immunology Research. 8 , p. 530-543 14 p.

All research output

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