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prof. dr. J.H.E. Kuball

prof. dr. J.H.E. Kuball

Full Professor
prof. dr. J.H.E. Kuball
  • Center for Translational Immunology (CTI) Research
  • Department of Hematology

Biography

Biography

Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

Side Activities

Board activities

  • Chair Immunology Community Utrecht Life Science 2023-
  • Secretary-Team of GoCART Coalition 2023-
  • EBMT Chair Legal and Regulatory Affairs Committee 2019-
  • HOVON General board 2014-
  • KWF PPS commissie 2022-
  • KWF adviesraad  2016-2022
  • Wetenschappelijke raad KIKA 2018-2021

Translational Valorisation

  • Cofounder and shareholder of Gadeta  2015-
  • Patent holder on multipe inventions  licensed to Gadeta and Miltenyi Biotech  2012-
  • Receiving revenues from licensed patents in the field of genetic engineering 2021-

Memberships

  • ASH
  • EBMT
  • EHA Member
  • HOVON Leukemia working party
  • HOVON SCT working party 

External positions

  • Scientific advisor, GADETA, 2018 → 2020
  • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
  • Scientific cofounder and CSO, GADETA, 2015 → 2018
  • Shareholder, GADETA, 2015 → …
  • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
  • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)

Research Output (203)

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

Mamedov Murad R, Vedova Shane, Freimer Jacob W, Sahu Avinash Das, Ramesh Amrita, Arce Maya M, Meringa Angelo D, Ota Mineto, Chen Peixin Amy, Hanspers Kristina, Nguyen Vinh Q, Takeshima Kirsten A, Rios Anne C, Pritchard Jonathan K, Kuball Jürgen, Sebestyen Zsolt, Adams Erin J, Marson Alexander 30 Aug 2023, In: Nature. 621 , p. 188-195 8 p.

Graft engineering:how long can you wait, how low can you go, and pandemic readiness

Nijssen Klaartje, Westinga Kasper, Stuut Anniek, Janssen Anke, van Rhenen Anna, van der Wagen Lotte, Daenen Laura G M, Oostvogels Rimke, de Witte Moniek A, Kuball Jürgen 3 Apr 2023, In: Bone Marrow Transplantation. 58 , p. 820-822 3 p.

Activity of ex vivo graft and DLI Engineering within the last decade increases, a survey from the EBMT Cellular Therapy & Immunobiology Working Party

de Witte M A, Mooyaart J E, Hoogenboom J D, Chabannon C, Malard F, Ruggeri A, Kuball J 18 Mar 2023, In: Bone Marrow Transplantation. 58 , p. 719-722 4 p.

Serpin B9 controls tumor cell killing by CAR T cells

Kimman Thomas, Slomp Anne, Martens Anne, Grabherr Sarah, Li Shuang, van Diest Eline, Meeldijk Jan, Kuball Jurgen, Minnema Monique C., Eldering Eric, Bovenschen Niels, Sebestyén Zsolt, Peperzak Victor 17 Mar 2023, In: Journal for ImmunoTherapy of Cancer. 11

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Ruggeri Annalisa, de Wreede Liesbeth C., Müller Carlheinz R., Crivello Pietro, Bonneville Edouard F., Petersdorf Effie W., Socié Gerard, Dubois Valérie, Niittyvuopio Riitta, Peräsaari Juha, Yakoub-Agha Ibrahim, Cornelissen Jan J., Wieten Lotte, Gedde-Dahl Tobias, Forcade Edouard, Crawley Charles R., Marsh Steven G.E., Gandemer Virginie, Tholouli Eleni, Bulabois Claude Eric, Huynh Anne, Choi Goda, Deconinck Eric, Itäla-Remes Maija, Lenhoff Stig, Bengtsson Mats, Johansson Jan Erik, van Gorkom Gwendolyn, Hoogenboom Jorinde D., Vago Luca, Rocha Vanderson, Bonini Chiara, Chabannon Christian, Fleischhauer Katharina, Clausen Johannes, Holter Wolfgang, Kalhs Peter, Beguin Yves, Bron Dominique, Deeren Dries, Lung Wu Ka, Kerre Tessa, Poiré Xavier, Selleslag Dominik, Schroyens Wilfried, Jindra Pavel, Mayer Jiri, Vydra Jan, Zák Pavel, Kuball Jürgen, 1 Feb 2023, In: Haematologica. 108 , p. 645-652 8 p.

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

van Diest Eline, Nicolasen Mara J T, Kramer Lovro, Zheng Jiali, Hernández-López Patricia, Beringer Dennis X, Kuball Jürgen 5 Jan 2023, In: Frontiers in Immunology. 13

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies

Meringa A D, Hernández-López P, Cleven A, de Witte M, Straetemans T, Kuball J, Beringer D X, Sebestyen Z 2023, In: Frontiers in Immunology. 14 , p. 1-7

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Huyveneers Laura E.P., Bruns Anke, Stam Arjen, Ellerbroek Pauline, de Jong Dorien, Nagy Noémi A., Gumbs Stephanie B.H., Tesselaar Kiki, Bosman Kobus, Salgado Maria, Hütter Gero, Brosens Lodewijk A.A., Kwon Mi, Diez Martin Jose, van der Meer Jan T.M., de Kort Theun M., Sáez-Cirión Asier, Schulze zur Wiesch Julian, Boelens Jaap Jan, Martinez-Picado Javier, Kuball Jürgen H.E., Wensing Annemarie M.J., Nijhuis Monique, 17 Sep 2022, In: Viruses. 14

Uncovering the mode of action of engineered T cells in patient cancer organoids

Dekkers Johanna F., Alieva Maria, Cleven Astrid, Keramati Farid, Wezenaar Amber K.L., van Vliet Esmée J., Puschhof Jens, Brazda Peter, Johanna Inez, Meringa Angelo D., Rebel Heggert G., Buchholz Maj Britt, Barrera Román Mario, Zeeman Amber L., de Blank Sam, Fasci Domenico, Geurts Maarten H., Cornel Annelisa M., Driehuis Else, Millen Rosemary, Straetemans Trudy, Nicolasen Mara J.T., Aarts-Riemens Tineke, Ariese Hendrikus C.R., Johnson Hannah R., van Ineveld Ravian L., Karaiskaki Froso, Kopper Oded, Bar-Ephraim Yotam E., Kretzschmar Kai, Eggermont Alexander M.M., Nierkens Stefan, Wehrens Ellen J., Stunnenberg Henk G., Clevers Hans, Kuball Jürgen, Sebestyen Zsolt, Rios Anne C. 25 Jul 2022, In: Nature Biotechnology. 41 , p. 60-69 10 p.

Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia:A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Ruggeri Annalisa, Galimard Jacques-Emmanuel, Labopin Myriam, Rafii Hanadi, Blaise Didier, Ciceri Fabio, Diez-Martin Jose-Luiz, Cornelissen Jan, Chevallier Patrice, Sanchez-Guijo Fermin, Nicholson Emma, Castagna Luca, Forcade Edouard, Kuball Jürgen, Rovira Montserrat, Koc Yener, Pavlu Jiri, Gulbas Zafar, Vydra Jan, Baron Frederic, Sanz Jaime, Spyridonidis Alexandros, Savani Bipin, Gluckman Eliane, Nagler Arnon, Mohty Mohamad 10 Jul 2022, In: Transplantation and Cellular Therapy. 28 , p. 710.e1-710.e10

All research output

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