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dr. J.H.W. (Jeanette) Leusen

Associate Professor

  • Laboratory for Translational Immunology (LTI)

Research Output (110)

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity

Lohse Stefan, Loew Sebastian, Kretschmer Anna, Jansen J H Marco, Meyer Saskia, Ten Broeke Toine, Rösner Thies, Dechant Michael, Derer Stefanie, Klausz Katja, Kellner Christian, Schwanbeck Ralf, French Ruth R, Tipton Thomas R W, Cragg Mark S, Schewe Denis M, Peipp Matthias, Leusen Jeanette H W, Valerius Thomas mei 2018, In: British Journal of Haematology. 181 , p. 413-417

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo

Jacobino Shamir R., Nederend Maaike, Reijneveld J. Frederiek, Augustijn Daan, Jansen J. H.Marco, Meeldijk Jan, Reiding Karli R., Wuhrer Manfred, Coenjaerts Frank E.J., Hack C. Erik, Bont Louis J., Leusen Jeanette H.W. apr 2018, In: mAbs. 10 , p. 453-462 10 p.

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

Ten Broeke Toine, Honing Henk, Brandsma Arianne M., Jacobino Shamir, Bakema Jantine E., Kanters Deon, van der Linden Jan A.M., Bracke Madelon, Koenderman Leo, Leusen Jeanette H.W. 1 jan 2018, In: Frontiers in Immunology. 9 1 p.

Single nucleotide polymorphisms of the high affinity IgG receptor FcγRI reduce immune complex binding and downstream effector functions

Brandsma Arianne M., Ten Broeke Toine, Van Dueren Den Hollander Evelien, Caniels Thomas G., Kardol-Hoefnagel Tineke, Kuball Jürgen, Leusen Jeanette H.W. 16 aug 2017, In: Journal of Immunology. 199 , p. 2432-2439 8 p.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo

Lehmann Christian H K, Baranska Anna, Heidkamp Gordon F, Heger Lukas, Neubert Kirsten, Lühr Jennifer J, Hoffmann Alana, Reimer Katharina C, Brückner Christin, Beck Simone, Seeling Michaela, Kießling Melissa, Soulat Didier, Krug Anne B, Ravetch Jeffrey V, Leusen Jeanette H W, Nimmerjahn Falk, Dudziak Diana 7 apr 2017, In: Journal of Experimental Medicine. 214 , p. 1509-1528 20 p.

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

Jacobino Shamir R., Nederend Maaike, Hennus Marije, Houben Michiel L. , Ngwuta Joan O., Viveen Marco, Coenjaerts Frank E.J., Hack C. Erik, van Neerven R. J Joost, Graham Barney S., Bont Louis, Leusen Jeanette H W nov 2016, In: Journal of Allergy and Clinical Immunology. 138 , p. 1477–1480.e5

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain"

Brandsma Arianne M, Hogarth P Mark, Nimmerjahn Falk, Leusen Jeanette H W 16 aug 2016, In: Immunity. 45 , p. 225-226 2 p.

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

Overdijk Marije B, Jansen J H Marco, Nederend Maaike, Lammerts van Bueren Jeroen J, Groen Richard W J, Parren Paul W H I, Leusen Jeanette H W, Boross Peter 1 aug 2016, In: Journal of Immunology. 197 , p. 807-813 7 p.

Intravenous immune globulin suppresses angiogenesis in mice and humans

Yasuma Reo, Cicatiello Valeria, Mizutani Takeshi, Tudisco Laura, Kim Younghee, Tarallo Valeria, Bogdanovich Sasha, Hirano Yoshio, Kerur Nagaraj, Li Shengjian, Yasuma Tetsuhiro, Fowler Benjamin J, Wright Charles B, Apicella Ivana, Greco Adelaide, Brunetti Arturo, Ambati Balamurali K, Helmers Sevim Barbasso, Lundberg Ingrid E, Viklicky Ondrej, Leusen Jeanette HW, Verbeek J Sjef, Gelfand Bradley D, Bastos-Carvalho Ana, De Falco Sandro, Ambati Jayakrishna 1 mrt 2016, In: Signal transduction and targeted therapy. 1

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

Bogdanovich Sasha, Kim Younghee, Mizutani Takeshi, Yasuma Reo, Tudisco Laura, Cicatiello Valeria, Bastos-Carvalho Ana, Kerur Nagaraj, Hirano Yoshio, Baffi Judit Z, Tarallo Valeria, Li Shengjian, Yasuma Tetsuhiro, Arpitha Parthasarathy, Fowler Benjamin J, Wright Charles B, Apicella Ivana, Greco Adelaide, Brunetti Arturo, Ruvo Menotti, Sandomenico Annamaria, Nozaki Miho, Ijima Ryo, Kaneko Hiroki, Ogura Yuichiro, Terasaki Hiroko, Ambati Balamurali K, Leusen Jeanette HW, Langdon Wallace Y, Clark Michael R, Armour Kathryn L, Bruhns Pierre, Verbeek J Sjef, Gelfand Bradley D, De Falco Sandro, Ambati Jayakrishna 27 feb 2016, In: Signal transduction and targeted therapy. 1