Back

dr. J.H.W. (Jeanette) Leusen

Associate Professor
dr. J.H.W. (Jeanette) Leusen
  • Laboratory for Translational Immunology (LTI)

Biography

Biography

Dr. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 120 publications in peer-reviewed journals and is inventor on 10 patent applications. Her group of 24 FTE works on the mechanism of action of therapeutic antibodies, with a special interest in IgA as a novel class of antibody for the treatment of both malignant as infectious disease.

 

See her research group webpage here >

Side Activities

Dr Leusen is the scientific founder of TigaTx in 2018, a spin-off company on engineered IgA as therapeutic antibody in oncology.

Dr Leusen is senior editor of several Immunology/cancer journals and was organizer of the FASEB meeting on Immunoreceptors of 2014 and 2016, and was vice chair of the Gordon Research Conference on Antibody Biology and Engineering in 2018, and main chair in 2022, https://www.grc.org/antibody-biology-and-engineering-conference/2022

Fellowship and Awards

Dr Leusen holds several grants from Health Holland, KWF, Villa Joep! and industry.

Research Output (112)

Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV

Nederend Maaike, van Stigt Arthur H., Jansen J. H.Marco, Jacobino Shamir R., Brugman Sylvia, de Haan Cornelis A.M., Bont Louis J., van Neerven R. J.Joost, Leusen Jeanette H.W. 6 aug 2020, In: Frontiers in Immunology. 11 , p. 1-9

gamma 9 delta 2T cell diversity and the receptor interface with tumor cells

Vyborova Anna, Beringer Dennis X, Fasci Domenico, Karaiskaki Froso, van Diest Eline, Kramer Lovro, de Haas Aram, Sanders Jasper, Janssen Anke, Straetemans Trudy, Olive Daniel, Leusen Jeanette Hw, Boutin Lola, Nedellec Steven, Schwartz Samantha L, Wester Michael J, Lidke Keith A, Scotet Emmanuel, Lidke Diane, Heck Albert Jr, Sebestyen Zsolt, Kuball Jurgen 2 jun 2020, In: Journal of Clinical Investigation. 130 , p. 4637-4651 15 p.

IgA-mediated killing of tumor cells by neutrophils is enhanced by CD47–SIRPA checkpoint inhibition

Treffers Louise W, Ten Broeke Toine, Rösner Thies, Jansen J H Marco, van Houdt Michel, Kahle Steffen, Schornagel Karin, Verkuijlen Paul J J H, Prins Jan M, Franke Katka, Kuijpers Taco W, van den Berg Timo K, Valerius Thomas, Leusen Jeanette H W, Matlung Hanke L 1 jan 2020, In: Cancer Immunology Research. 8 , p. 120-130 11 p.

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 okt 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

van der Schoot Johan M S, Fennemann Felix L, Valente Michael, Dolen Yusuf, Hagemans Iris M, Becker Anouk M D, Le Gall Camille M, van Dalen Duco, Cevirgel Alper, van Bruggen Jaco A C, Engelfriet Melanie, Caval Tomislav, Bentlage Arthur E H, Fransen Marieke F, Nederend Maaike, Leusen Jeanette H W, Heck Albert J R, Vidarsson Gestur, Figdor Carl G, Verdoes Martijn, Scheeren Ferenc A 28 aug 2019, In: Science advances. 5 12 p.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Logtenberg Meike E W, Jansen J H Marco, Raaben Matthijs, Toebes Mireille, Franke Katka, Brandsma Arianne M, Matlung Hanke L, Fauster Astrid, Gomez-Eerland Raquel, Bakker Noor A M, van der Schot Simone, Marijt Koen A, Verdoes Martijn, Haanen John B A G, van den Berg Joost H, Neefjes Jacques, van den Berg Timo K, Brummelkamp Thijn R, Leusen Jeanette H W, Scheeren Ferenc A, Schumacher Ton N apr 2019, In: Nature Medicine. 25 , p. 612-619 8 p.

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

Bras Anne E, de Haas Valerie, van Stigt Arthur, Jongen-Lavrencic Mojca, Beverloo H Berna, Te Marvelde Jeroen G, Zwaan C Michel, van Dongen Jacques J M, Leusen Jeanette H W, van der Velden Vincent H J 1 mrt 2019, In: Cytometry. Part B, Clinical Cytometry.. 96 , p. 134-142 9 p.

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Valerius Thomas, Rösner Thies, Leusen Jeanette H W 31 jan 2019, In: The New England journal of medicine. 380 , p. 496-497 2 p.

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Brandsma Arianne M, Bondza Sina, Evers Mitchell, Koutstaal Rosanne, Nederend Maaike, Jansen J H Marco, Rösner Thies, Valerius Thomas, Leusen Jeanette H W, Ten Broeke Toine 1 jan 2019, In: Frontiers in Immunology. 10

Immune Effector Functions of Human IgG2 Antibodies against EGFR

Rösner Thies, Kahle Steffen, Montenegro Francesca, Matlung Hanke L, Jansen J H Marco, Evers Mitchell, Beurskens Frank, Leusen Jeanette H W, van den Berg Timo K, Valerius Thomas jan 2019, In: MOLECULAR CANCER THERAPEUTICS. 18 , p. 75-88 14 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht

Contact

Emergency?

Directions

Appointments

Practical

umcutrecht.nl maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet