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dr. J.H.W. (Jeanette) Leusen

Associate Professor

  • Laboratory for Translational Immunology (LTI)

Research Output (110)

IgA-mediated killing of tumor cells by neutrophils is enhanced by CD47–SIRPA checkpoint inhibition

Treffers Louise W, Ten Broeke Toine, Rösner Thies, Jansen J H Marco, van Houdt Michel, Kahle Steffen, Schornagel Karin, Verkuijlen Paul J J H, Prins Jan M, Franke Katka, Kuijpers Taco W, van den Berg Timo K, Valerius Thomas, Leusen Jeanette H W, Matlung Hanke L 1 jan 2020, In: Cancer Immunology Research. 8 , p. 120-130 11 p.

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 okt 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

van der Schoot Johan M S, Fennemann Felix L, Valente Michael, Dolen Yusuf, Hagemans Iris M, Becker Anouk M D, Le Gall Camille M, van Dalen Duco, Cevirgel Alper, van Bruggen Jaco A C, Engelfriet Melanie, Caval Tomislav, Bentlage Arthur E H, Fransen Marieke F, Nederend Maaike, Leusen Jeanette H W, Heck Albert J R, Vidarsson Gestur, Figdor Carl G, Verdoes Martijn, Scheeren Ferenc A 28 aug 2019, In: Science advances. 5 12 p.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Logtenberg Meike E W, Jansen J H Marco, Raaben Matthijs, Toebes Mireille, Franke Katka, Brandsma Arianne M, Matlung Hanke L, Fauster Astrid, Gomez-Eerland Raquel, Bakker Noor A M, van der Schot Simone, Marijt Koen A, Verdoes Martijn, Haanen John B A G, van den Berg Joost H, Neefjes Jacques, van den Berg Timo K, Brummelkamp Thijn R, Leusen Jeanette H W, Scheeren Ferenc A, Schumacher Ton N apr 2019, In: Nature Medicine. 25 , p. 612-619 8 p.

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

Bras Anne E, de Haas Valerie, van Stigt Arthur, Jongen-Lavrencic Mojca, Beverloo H Berna, Te Marvelde Jeroen G, Zwaan C Michel, van Dongen Jacques J M, Leusen Jeanette H W, van der Velden Vincent H J 1 mrt 2019, In: Cytometry. Part B, Clinical Cytometry.. 96 , p. 134-142 9 p.

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Valerius Thomas, Rösner Thies, Leusen Jeanette H W 31 jan 2019, In: The New England journal of medicine. 380 , p. 496-497 2 p.

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Brandsma Arianne M, Bondza Sina, Evers Mitchell, Koutstaal Rosanne, Nederend Maaike, Jansen J H Marco, Rösner Thies, Valerius Thomas, Leusen Jeanette H W, Ten Broeke Toine 1 jan 2019, In: Frontiers in Immunology. 10

Immune Effector Functions of Human IgG2 Antibodies against EGFR

Rösner Thies, Kahle Steffen, Montenegro Francesca, Matlung Hanke L, Jansen J H Marco, Evers Mitchell, Beurskens Frank, Leusen Jeanette H W, van den Berg Timo K, Valerius Thomas jan 2019, In: MOLECULAR CANCER THERAPEUTICS. 18 , p. 75-88 14 p.

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness

Mazur Natalie I., Horsley Nicole M., Englund Janet A., Nederend Maaike, Magaret Amalia, Kumar Azad, Jacobino Shamir R., de Haan Cornelis A.M., Khatry Subarna K., LeClerq Steven C., Steinhoff Mark C., Tielsch James M., Katz Joanne, Graham Barney S., Bont Louis J., Leusen Jeanette H.W., Chu Helen Y. 10 aug 2018, In: Journal of Infectious Diseases. 219 , p. 59-67 9 p.

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Matlung Hanke L., Babes Liane, Zhao Xi Wen, van Houdt Michel, Treffers Louise W., van Rees Dieke J., Franke Katka, Schornagel Karin, Verkuijlen Paul, Janssen Hans, Halonen Pasi, Lieftink Cor, Beijersbergen Roderick L., Leusen Jeanette H.W., Boelens Jaap J., Kuhnle Ingrid, van der Werff Ten Bosch Jutte, Seeger Karl, Rutella Sergio, Pagliara Daria, Matozaki Takashi, Suzuki Eiji, Menke-van der Houven van Oordt Catharina Willemien, van Bruggen Robin, Roos Dirk, van Lier Rene A.W., Kuijpers Taco W., Kubes Paul, van den Berg Timo K. 26 jun 2018, In: Cell Reports. 23 , p. 3946-3959.e6