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prof. dr. J.H.W. (Jeanette) Leusen

prof. dr. J.H.W. (Jeanette) Leusen

Full Professor

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Research Output (138)

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo

Jacobino Shamir R., Nederend Maaike, Reijneveld J. Frederiek, Augustijn Daan, Jansen J. H.Marco, Meeldijk Jan, Reiding Karli R., Wuhrer Manfred, Coenjaerts Frank E.J., Hack C. Erik, Bont Louis J., Leusen Jeanette H.W. Apr 2018, In: mAbs. 10 , p. 453-462 10 p.

Single nucleotide polymorphisms of the high affinity IgG receptor FcγRI reduce immune complex binding and downstream effector functions

Brandsma Arianne M., Ten Broeke Toine, Van Dueren Den Hollander Evelien, Caniels Thomas G., Kardol-Hoefnagel Tineke, Kuball Jürgen, Leusen Jeanette H.W. 16 Aug 2017, In: Journal of Immunology. 199 , p. 2432-2439 8 p.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo

Lehmann Christian H K, Baranska Anna, Heidkamp Gordon F, Heger Lukas, Neubert Kirsten, Lühr Jennifer J, Hoffmann Alana, Reimer Katharina C, Brückner Christin, Beck Simone, Seeling Michaela, Kießling Melissa, Soulat Didier, Krug Anne B, Ravetch Jeffrey V, Leusen Jeanette H W, Nimmerjahn Falk, Dudziak Diana 7 Apr 2017, In: Journal of Experimental Medicine. 214 , p. 1509-1528 20 p.

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

Jacobino Shamir R., Nederend Maaike, Hennus Marije, Houben Michiel L. , Ngwuta Joan O., Viveen Marco, Coenjaerts Frank E.J., Hack C. Erik, van Neerven R. J Joost, Graham Barney S., Bont Louis, Leusen Jeanette H W Nov 2016, In: Journal of Allergy and Clinical Immunology. 138 , p. 1477–1480.e5

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain"

Brandsma Arianne M, Hogarth P Mark, Nimmerjahn Falk, Leusen Jeanette H W 16 Aug 2016, In: Immunity. 45 , p. 225-226 2 p.

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

Overdijk Marije B, Jansen J H Marco, Nederend Maaike, Lammerts van Bueren Jeroen J, Groen Richard W J, Parren Paul W H I, Leusen Jeanette H W, Boross Peter 1 Aug 2016, In: Journal of Immunology. 197 , p. 807-813 7 p.

Intravenous immune globulin suppresses angiogenesis in mice and humans

Yasuma Reo, Cicatiello Valeria, Mizutani Takeshi, Tudisco Laura, Kim Younghee, Tarallo Valeria, Bogdanovich Sasha, Hirano Yoshio, Kerur Nagaraj, Li Shengjian, Yasuma Tetsuhiro, Fowler Benjamin J, Wright Charles B, Apicella Ivana, Greco Adelaide, Brunetti Arturo, Ambati Balamurali K, Helmers Sevim Barbasso, Lundberg Ingrid E, Viklicky Ondrej, Leusen Jeanette HW, Verbeek J Sjef, Gelfand Bradley D, Bastos-Carvalho Ana, De Falco Sandro, Ambati Jayakrishna 1 Mar 2016, In: Signal transduction and targeted therapy. 1

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

Bogdanovich Sasha, Kim Younghee, Mizutani Takeshi, Yasuma Reo, Tudisco Laura, Cicatiello Valeria, Bastos-Carvalho Ana, Kerur Nagaraj, Hirano Yoshio, Baffi Judit Z, Tarallo Valeria, Li Shengjian, Yasuma Tetsuhiro, Arpitha Parthasarathy, Fowler Benjamin J, Wright Charles B, Apicella Ivana, Greco Adelaide, Brunetti Arturo, Ruvo Menotti, Sandomenico Annamaria, Nozaki Miho, Ijima Ryo, Kaneko Hiroki, Ogura Yuichiro, Terasaki Hiroko, Ambati Balamurali K, Leusen Jeanette HW, Langdon Wallace Y, Clark Michael R, Armour Kathryn L, Bruhns Pierre, Verbeek J Sjef, Gelfand Bradley D, De Falco Sandro, Ambati Jayakrishna 27 Feb 2016, In: Signal transduction and targeted therapy. 1

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Lohse Stefan, Meyer Saskia, Meulenbroek Laura A P M, Jansen J H Marco, Nederend Maaike, Kretschmer Anna, Klausz Katja, Möginger Uwe, Derer Stefanie, Rösner Thies, Kellner Christian, Schewe Denis, Sondermann Peter, Tiwari Sanjay, Kolarich Daniel, Peipp Matthias, Leusen Jeanette H W, Valerius Thomas 15 Jan 2016, In: Cancer Research. 76 , p. 403-417 15 p.

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

Meyer Saskia, Nederend Maaike, Jansen J H Marco, Reiding Karli R, Jacobino Shamir R, Meeldijk Jan, Bovenschen Niels, Wuhrer Manfred, Valerius Thomas, Ubink Ruud, Boross Peter, Rouwendal Gerard, Leusen Jeanette H W 2 Jan 2016, In: mAbs. 8 , p. 87-98 12 p.

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