prof. dr. S.C. (Sabine) Linn
prof. dr. S.C. (Sabine) Linn
- Department of Pathology
Research Programs
Biography
Biography
Dr. Sabine Linn is a professor of translational oncology focusing on breast cancer at Utrecht University, The Netherlands. Linn received her medical degree (1991, cum laude) at the State University Leiden, The Netherlands, and her internal medicine board certification (2000) at the University Medical Center Utrecht, The Netherlands. She earned her PhD (1998) on the subject of multidrug resistance in solid tumors from the Free University of Amsterdam under supervision of prof. Dr H.M. Pinedo.
She was awarded a Dutch Cancer Society Research Fellowship in 2000 and developed two conditional knock-out mouse models, one for non-small cell lung cancer and one for small cell lung cancer, respectively, in close collaboration with Dr Ralph Meuwissen in the laboratory of prof. Dr A.J. Berns at the Netherlands Cancer Institute, Amsterdam, The Netherlands. From 2001 to 2002 she was a postdoctoral research fellow in the laboratories of prof. Dr P.O. Brown, and prof. Dr M. van de Rijn, at Stanford University Medical School, Stanford, CA, where she contributed to the development of a molecular classification for soft tissue sarcomas. She returned to the Netherlands Cancer Institute in Amsterdam, where she earned her medical oncology certification (2002-2005) and became a senior staff member of the Division of Medical Oncology (2003).
Since 2005 she has also been a group leader at the Division of Molecular Pathology at the Netherlands Cancer Institute where she and her research group focus on the molecular dissection of breast cancer by differential drug sensitivity. To further develop this research line Dr. Linn was awarded a Dutch Cancer Society Clinical Research Award in 2006. From 2008-2012, Dr Linn served as chair of the Working Group on (neo)adjuvant systemic therapy of the Dutch Breast Cancer Trialists' Group (BOOG).
Side Activities
Neven activiteiten van Sabine Linn
Family Name:
Linn
Christian names:
Sabine Charlotte
BIG number:
99032942301
Working address:
Dept. of Medical Oncology
Netherlands Cancer Institute
Plesmanlaan 121
1066 CX Amsterdam
The Netherlands
Telephone:
+31 20 5129111
Fax:
+31 20 5122572
Advisory boards and consultancies
2012 – present
Function: Member Scientific Advisory Board
Organization: Cergentis, a spin-off company for targeted amplification of complete genes, The Netherlands
Personal income: No
2016
Function: Member Lynparza (Olaparib) AstraZeneca Global Advisory Board
Organization: AstraZeneca
Personal income: No
2016 – 2017
Function: Member IBM Watson Health Oncology Global Advisory Board
Organization: IBM, Boston, MA, USA
Personal income: No
Educational and scientific committees
2003 – 2020
Function: Member of the NKI-AVL Organizing Committee for Continuing Medical Education Program for Dutch Medical Oncologists “DONAMO (DOorlopende NAscholing Medische Oncologie)”
Organization: Netherlands Cancer Institute, Amsterdam, Netherlands
Personal income: No
2007 – 2015
Function: Member of the Dutch Society for Medical Oncology (NVMO) Advisory Board for the Dutch Institute for Healthcare Improvement (CBO) Breast Cancer Guidelines
Organization: Dutch Institute for Healthcare Improvement (CBO)
Personal income: No
2008 – 2013
Function: Chair Working Group (neo)adjuvant systemic therapy of Borstkanker Onderzoek Groep (BOOG) (Dutch Breast Cancer Trialists’ Group)
Organization: Dutch Breast Cancer Trialists’ Group
Personal income: No
2013 – 2019
Function: Member of Program Committee of Dutch and Flemish Annual Oncology Days (NVMO Oncologiedagen Nederland en Vlaanderen)
Organization: NVMO (Nederlandse Vereniging voor Medische Oncologie)
Personal income: No
2014 – present
Function: Member Committee on Personalised Medicine
Organization: ZonMw, The Netherlands
Personal income: No
2015 - present
Member Editorial Board of Breast Cancer Research
Organization: Springer Nature
Personal income: No
2015
Function: Member Scientific Advisory Group
Organization: European Medicines Agency (EMA) London, UK
Personal income: No
2016 – 2017
Function: Member RiskAp Expert Group on breast cancer screening
Organization: German Federal Ministry of Education and Research
Personal income: No
2016 – 2017
Function: Member Scientific Evaluation Committee Institut National du Cancer, France
Organization: Institut National du Cancer (INCA), Paris, France
Personal income: No
2016 – 2017
Function: Member Expert Review Panel CRUK and EPSRC Cancer Imaging Centres (Oxford University, Cambridge University, King’s College London/University College London, The Institute of Cancer Research)
Organization: Cancer Research United Kingdom (CRUK)
Personal income: No
2016 – 2017
Function: Member IMPAKT 2017 Scientific Committee, Brussels, Belgium
Organization: ESMO (European Society of Medical Oncology) and BIG (Breast International Group)
Personal income: No
2016 – 2018
Function: Member ESMO 2018 scientific subcommittee breast cancer, early
Organization: ESMO (European Society of Medical Oncology)
Personal income: No
2017 – 2019
Function: Co-chair (with Alberto Bardelli) ESMO-EACR 2019 scientific subcommittee Translational Research
Organization: ESMO (European Society of Medical Oncology)
Personal income: No
2017 – 2020
Function: Member evaluation board of the panel LS4 “Physiology, Pathophysiology and Endocrinology” for European Research Council Consolidator Grants (CoG) in 2018, and 2020
Organization: European Commission
Personal income: Yes, > 2,200 Euro/year
2018 - present
Faculty ENDEAVOR workshops for European future breast cancer leaders in the field
2021 – present
Function: Member VIDI committee Dutch Research Council (NWO)
Organisation: Dutch Research Council (NWO)
Personal income: yes, < 2,200 euro/year
2022 – present
Member Health Council of the Netherlands – Independent scientific advisory body for government and parliament
Research Output (140)
Vliek Sonja, Hilbers Florentine S., van Werkhoven Erik, Mandjes Ingrid, Kessels Rob, Kleiterp Sieta, Lips Esther H., Mulder Lennart, Kayembe Mutamba T., Loo Claudette E., Russell Nicola S., Vrancken Peeters Marie Jeanne T.F.D., Holtkamp Marjo J., Schot Margaret, Baars Joke W., Honkoop Aafke H., Vulink Annelie J.E., Imholz Alex L.T., Vrijaldenhoven Suzan, van den Berkmortel Franchette W.P.J., Meerum Terwogt Jetske M., Schrama Jolanda G., Kuijer Philomeen, Kroep Judith R., van der Padt-Pruijsten Annemieke, Wesseling Jelle, Sonke Gabe S., Gilhuijs Kenneth G.A., Jager Agnes, Nederlof Petra, Linn Sabine C. Dec 2023, In: npj Breast Cancer. 9
Koole Simone N., Schouten Philip C., van Driel Willemien J., Sonke Gabe S., Linn Sabine C. 1 Dec 2022, In: International Journal of Cancer. 151 , p. 2057-2058 2 p.
Vliek Sonja B., Hilbers Florentine S., Jager Agnes, Retèl Valesca P., Bueno de Mesquita Jolien M., Drukker Caroline A., Veltkamp Sanne C., Zeillemaker Anneke M., Rutgers Emiel J., van Tinteren Harm, van Harten Wim H., van 't Veer Laura J., van de Vijver Marc J., Linn Sabine C. Nov 2022, In: European Journal of Cancer. 175 , p. 169-179 11 p.
de Wild Sabine R., de Munck Linda, Simons Janine M., Verloop Janneke, van Dalen Thijs, Elkhuizen Paula H.M., Houben Ruud M.A., van Leeuwen A. Elise, Linn Sabine C., Pijnappel Ruud M., Poortmans Philip M.P., Strobbe Luc J.A., Wesseling Jelle, Voogd Adri C., Boersma Liesbeth J. Sep 2022, In: The Lancet Oncology. 23 , p. 1201-1210 10 p.
Balkenende Eva M E, Dahhan Taghride, Beerendonk Catharina C M, Fleischer Kathrin, Stoop Dominic, Lambalk Cornelis B, Bos Annelies M E, Schats Roel, Smeenk Jesper M J, Louwé Leonie A, Cantineau Astrid E P, Bruin Jan Peter de, Linn Sabine C, van der Veen Fulco, van Wely Madelon, Goddijn Mariëtte 1 Jul 2022, In: Human Reproduction. 37 , p. 1786-1794 9 p.
Meijer Titia G, Nguyen Luan, Van Hoeck Arne, Sieuwerts Anieta M, Verkaik Nicole S, Ladan Marjolijn M, Ruigrok-Ritstier Kirsten, van Deurzen Carolien H M, van de Werken Harmen J G, Lips Esther H, Linn Sabine C, Memari Yasin, Davies Helen, Nik-Zainal Serena, Kanaar Roland, Martens John W M, Cuppen Edwin, Jager Agnes, van Gent Dik C 24 Jun 2022, In: Oncogene. 41 , p. 3498-3506 9 p.
de Boo Leonora W., Jóźwiak Katarzyna, Joensuu Heikki, Lindman Henrik, Lauttia Susanna, Opdam Mark, van Steenis Charlaine, Brugman Wim, Kluin Roelof J.C., Schouten Philip C., Kok Marleen, Nederlof Petra M., Hauptmann Michael, Linn Sabine C. 1 Jun 2022, In: British Journal of Cancer. 126 , p. 1401-1409 9 p.
Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord C J, Linn S, Bidard F-C, Richard F, Yang W W, Steele R E, Pettitt S J, Van Ongeval C, De Schepper M, Isnaldi E, Nevelsteen I, Smeets A, Punie K, Voorwerk L, Wildiers H, Floris G, Vincent-Salomon A, Derksen P W B, Neven P, Senkus E, Sawyer E, Kok M, Desmedt C 20 May 2022, In: Annals of oncology : official journal of the European Society for Medical Oncology. 33 , p. 769-785 17 p.
Opdam M, van der Noort V, Kleijn M, Glas A, Mandjes I, Kleiterp S, Hilbers F S, Kruger D T, Bins A D, de Jong P C, Schiphorst P P J B M, van Dalen T, Flameling B, Rietbroek R C, Beeker A, van den Heiligenberg S M, Bakker S D, Wymenga A N M, Oving I M, Bijlsma R M, van Diest P J, Vermorken J B, van Tinteren H, Linn S C 19 May 2022, In: Breast Cancer Research and Treatment. 194 , p. 265-278 14 p.
Tavares Sandra, Liv Nalan, Pasolli Milena, Opdam Mark, Rätze Max A K, Saornil Manuel, Sluimer Lilian M, Hengeveld Rutger C C, van Es Robert, van Werkhoven Erik, Vos Harmjan, Rehmann Holger, Burgering Boudewijn M T, Oosterkamp Hendrika M, Lens Susanne M A, Klumperman Judith, Linn Sabine C, Derksen Patrick W B 5 Apr 2022, In: Cell Reports. 39 , p. 1-24