prof. dr. L. Meyaard

prof. dr. L. Meyaard

Full Professor
prof. dr. L. Meyaard
  • Center for Translational Immunology (CTI)



Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.

Since 2000 she leads her own research group embedded in the Center Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1. She then extended her research towards other inhibitory receptors and studies these inhibitory receptors in the context of cancer, inflammation and immunopathology of viral infections.

In 2016-2017 she spent a year as visiting scientist at Yale Medical School in the lab of Professor Ruslan Medzhitov. In 2018 she became a principle investigator at Oncode Institite for cancer research. Since september 2018 she is department head of the Center for Translational Immunology at the UMC Utrecht.

In her current work, Meyaard continues to ask fundamental immunological questions regarding inhibitory receptors to develop novel concepts that can be translated to clinic application. She proposed that inhibitory receptors can be grouped in functional categories with different purposes. Recently, her lab identified SIRL-1 as a receptor recognizing endogenous and microbial molecular patterns, introducing the concept of inhibitory pattern recognition receptors. Furthermore, they discovered that inflammation can rewire inhibitory signaling and influence the functional outcome. Together with clinicians, Meyaard translates these concepts to cancer and inflammation. By collaborating with multiple biotech and pharmaceutical companies she aims for clinical application of her work.

Side Activities

Investigator at Oncode Institute

Member of review panel ENW Open Program

Member of the ESCUlab review committee of the European Lead Factory

Collaborative research agreements with NextCure, NGM Biopharmaceuticals, Boehringer Ingelheim


Fellowship and Awards

1999-2001      Fellow of the Royal Dutch Academy of Science (KNAW)

2001                NWO Vidi

2002                NWO Aspasia

2014                NWO Vici

Research Output (121)

Sensing context:Inhibitory receptors on non-hematopoietic cells

von Richthofen Helen J., Meyaard Linde May 2023, In: European Journal of Immunology. 53 10 p.

VSTM1-v2 does not drive human Th17 cell differentiation:A replication study

von Richthofen Helen J., Hafkamp Florianne M.J., van Haperen Anouk, de Jong Esther C., Meyaard Linde Apr 2023, In: PLoS ONE. 18

Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

von Richthofen Helen J., Westerlaken Geertje H.A., Gollnast Doron, Besteman Sjanna, Delemarre Eveline M., Rodenburg Karlijn, Moerer Petra, Stapels Daphne A.C., Andiappan Anand K., Rötzschke Olaf, Nierkens Stefan, Leavis Helen L., Bont Louis J., Rooijakkers Suzan H.M., Meyaard Linde 15 Feb 2023, In: Journal of immunology (Baltimore, Md. : 1950). 210 , p. 389-397 9 p.

Differential isoform expression of Allergin-1 during acute and chronic inflammation

Geerdink Ruben J., Pascoal Ramos Maria Inês, van den Hoogen Luuk L., Radstake Timothy R.D.J., Shibayama Shiro, Shibuya Akira, Bont Louis, Meyaard Linde Dec 2022, In: Immunity, inflammation and disease. 10 , p. 1-9

Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Besteman Sjanna B, Phung Emily, Raeven Henriette H M, Amatngalim Gimano D, Rumpret Matevž, Crabtree Juliet, Schepp Rutger M, Rodenburg Lisa W, Siemonsma Susanna G, Verleur Nile, van Slooten Rianne, Duran Karen, van Haaften Gijs, Beekman Jeffrey M, Chang Lauren A, Meyaard Linde, van der Bruggen Tjomme, Berbers Guy A M, Derksen Nicole, Nierkens Stefan, Morabito Kaitlyn M, Ruckwardt Tracy J, Kurt-Jones Evelyn A, Golenbock Douglas, Graham Barney S, Bont Louis J 16 Apr 2022, In: The Journal of infectious diseases. 226 , p. 258-269 12 p.

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

van der Vlist Michiel, Raoof Ramin, Willemen Hanneke L.D.M., Prado Judith, Versteeg Sabine, Martin Gil Christian, Vos Martijn, Lokhorst Roeland E., Pasterkamp R. Jeroen, Kojima Toshiyuki, Karasuyama Hajime, Khoury-Hanold William, Meyaard Linde, Eijkelkamp Niels 14 Dec 2021, In: Neuron. 110 , p. 613-626

Inhibitory pattern recognition receptors

Rumpret Matevž, von Richthofen Helen J, Peperzak Victor, Meyaard Linde 14 Dec 2021, In: Journal of Experimental Medicine. 219

Signaling by the inhibitory receptor CD200R is rewired by type I interferon

van der Vlist Michiel, Pascoal Ramos M Inês , van den Hoogen Lucas L, Hiddingh Sanne, Timmerman Laura M, de Hond Titus A P, Kaan Ellen D, van der Kroef Maarten, Lebbink Robert Jan, Peters Florence M A, Khoury-Hanold William, Fritsch-Stork Ruth, Radstake Timothy R D J, Meyaard Linde 12 Oct 2021, In: Science Signaling [E]. 14 , p. 1-11

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1

Vijver Saskia V., Singh Akashdip, Mommers-Elshof Eline T.A.M., Meeldijk Jan, Copeland Ronald, Boon Louis, Langermann Sol, Flies Dallas, Meyaard Linde, Ramos M. Inês Pascoal 7 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-13

Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic alpha-helical peptides

Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, van Strijp Jos A.G., Landau Meytal, Ovaa Huib, van Sorge Nina M., Meyaard Linde Oct 2021, In: FASEB Journal. 35 , p. 1-19 19 p.

All research output

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