prof. dr. K.G.M. Moons

prof. dr. K.G.M. Moons

Full Professor
prof. dr. K.G.M. Moons
  • Julius Center, dept. Epidemiology & Health Economics

Research Programs




K.G.M. (Carl) Moons is Professor of Clinical Epidemiology at the Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. He is Director of Research of the Julius Center (550 Employees). He headed the research program ‘Research Methodology’ until 2019. 


- MSc in Biomedical Sciences (Radboud University Nijmegen, 1992);

- MSc in Clinical Epidemiology (Erasmus University Rotterdam, 1994)

- PhD in Medicine (Erasmus University Rotterdam, 1996).

Since 2005 full Professor of Clinical Epidemiology at the Julius Center,UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

He was a visiting Professor at the University of Virginia, USA (2002) and at Tokai University, Japan (2005-2010).

He has been a member of various committees, e.g. Netherlands Organization for Scientific Research, Royal Dutch Academy of Sciences, Dutch Health Council, Cochrane Collaboration, and Medical Ethical Committees.

He is principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.

Indicators of Research Excellence

Over his career Professor Moons has published over 480 peer-reviewed publications (including scientific papers and book chapters) with >22,000 citations (H index 72, Scopus). He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 10 million euro as co-PI). The (societal) impact of his research record has also been recognised by membership of the Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines. He also teaches bachelor, master, post doctoral students in clinical research across the world, including Asia and Africa.


Side Activities

Adjunct Professor of Clinical Epidemiology, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA. (since 2005)

Adjunct Professor of Clinical Epidemiology, Center of Statistics in Medicine, Oxford University, Oxford, UK (since 2017)

Staff Cochrane Netherlands.

Member of Cochrane Collaboration; Convenor Cochrane's Prognosis Methods Group; Member of IPD Meta-analysis group and Diagnostic Test Accuracy Group.

Editor-in-chief BMC Diagnostic and Prognostic Research.

Member of the Dutch Health Council

Chair of The Netherlands Implant Side-effects Expertise Center

Initiator and ambassador of Health Innovation Initiative Holland (Hii Holland)

Fellowship and Awards

2003 VIDI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, “Diagnostic Prediction Rules; innovative methods to improve their applicability”.

2008 TOP Grant         The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, "Clinical prediction rules: towards a framework for meta-analysis, validation, and updating"

2010 VICI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator “A different view on diagnostic research: a framework for studying the  Differential diagnosis and diseases with an imperfect or missing reference test"

Research Output (690)

Prognosis and prediction of antibiotic benefit in adults with clinically diagnosed acute rhinosinusitis:an individual participant data meta-analysis

Hoogland Jeroen, Takada Toshihiko, van Smeden Maarten, Rovers Maroeska M, de Sutter An I, Merenstein Daniel, Kaiser Laurent, Liira Helena, Little Paul, Bucher Heiner C, Moons Karel G M, Reitsma Johannes B, Venekamp Roderick P 5 Sep 2023, In: Diagnostic and Prognostic Research. 7

Dual hormone fully closed loop in type 1 diabetes:a randomised trial in the Netherlands - study protocol

Jančev Milena, Snoek Frank J., Frederix Geert W.J., Knottnerus Heleen, Blauw Helga, Witkop Maureen, Moons Karel G.M., Van Bon Arianne C., Devries J. Hans, Serné Erik H., Van Sloten Thomas T., De Valk Harold W. 23 Aug 2023, In: BMJ Open. 13

Systematic review finds "Spin" practices and poor reporting standards in studies on machine learning-based prediction models

Andaur Navarro Constanza L., Damen Johanna A.A., Takada Toshihiko, Nijman Steven W.J., Dhiman Paula, Ma Jie, Collins Gary S., Bajpai Ram, Riley Richard D., Moons Karel G.M., Hooft Lotty 4 Apr 2023, In: Journal of Clinical Epidemiology. 158 , p. 99-110 12 p.

Overinterpretation of findings in machine learning prediction model studies in oncology:a systematic review

Dhiman Paula, Ma Jie, Andaur Navarro Constanza L, Speich Benjamin, Bullock Garrett, Damen Johanna AA, Hooft Lotty, Kirtley Shona, Riley Richard D, Van Calster Ben, Moons Karel Gm, Collins Gary S 17 Mar 2023, In: Journal of Clinical Epidemiology. 157 , p. 120-133 14 p.

Accuracy of physicians' intuitive risk estimation in the diagnostic management of pulmonary embolism:An Individual Patient Data Meta-Analysis

Maanen Rosanne van, Martens Emily S L, Takada Toshihiko, Roy Pierre-Marie, de Wit Kerstin, Parpia Sameer, Kraaijpoel Noémie, Huisman Menno V, Wells Philip S, Le Gal Grégoire, Righini Marc, Freund Yonathan, Galipienzo Javier, van Es Nick, Blom Jeanet W, Moons Karel G M, Rutten Frans H, Smeden Maarten van, Klok Frederikus A, Geersing Geert-Jan, Luijken Kim 2023, In: Journal of thrombosis and haemostasis : JTH. 21 , p. 2873-2883 11 p.

Propensity-based standardization to enhance the validation and interpretation of prediction model discrimination for a target population

de Jong Valentijn M.T., Hoogland Jeroen, Moons Karel G.M., Riley Richard D., Nguyen Tri Long, Debray Thomas P.A. 2023, In: Statistics in Medicine. 42 , p. 3508-3528 21 p.

Minimal reporting improvement after peer review in reports of COVID-19 prediction models:systematic review

Hudda Mohammed T, Archer Lucinda, van Smeden Maarten, Moons Karel G M, Collins Gary S, Steyerberg Ewout W, Wahlich Charlotte, Reitsma Johannes B, Riley Richard D, Van Calster Ben, Wynants Laure 14 Dec 2022, In: Journal of Clinical Epidemiology. 154 , p. 75-84 10 p.

Systematic review identifies the design and methodological conduct of studies on machine learning-based prediction models

Andaur Navarro Constanza L, Damen Johanna Aa, van Smeden Maarten, Takada Toshihiko, Nijman Steven Wj, Dhiman Paula, Ma Jie, Collins Gary S, Bajpai Ram, Riley Richard D, Moons Karel Gm, Hooft Lotty 24 Nov 2022, In: Journal of Clinical Epidemiology. 154 , p. 8-22 15 p.

Diagnostic accuracy of SARS-CoV-2 rapid antigen self-tests in asymptomatic individuals in the Omicron period:a cross-sectional study

Venekamp Roderick P, Schuit Ewoud, Hooft Lotty, Veldhuijzen Irene K, van den Bijllaardt Wouter, Pas Suzan D, Zwart Vivian F, Lodder Esther B, Hellwich Marloes, Koppelman Marco, Molenkamp Richard, Wijers Constantijn Jh, Vroom Irene H, Smeets Leonard C, Nagel-Imming Carla R S, Han Wanda G H, van den Hof Susan, Kluytmans Jan AJW, van de Wijgert Janneke H M, Moons Karel G M 12 Nov 2022, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 29 , p. 391.e1-391.e7 7 p.

Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing:cross-sectional study

Schuit Ewoud, Venekamp Roderick P., Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Stohr Joep J.J.M., Lodder Esther B., Hellwich Marloes, Molenkamp Richard, Igloi Zsofia, Wijers Constantijn, Vroom Irene H., Nagel-Imming Carla R.S., Han Wanda G.H., Kluytmans Jan A.J.W., van den Hof Susan, van de Wijgert Janneke H.H.M., Moons Karel G.M. 24 Oct 2022, In: BMC Medicine. 20

All research output

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