prof. dr. G. Pasterkamp

prof. dr. G. Pasterkamp

Full Professor
prof. dr. G. Pasterkamp
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health



Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants and Finnish Academy of Sciences


Research Output (661)

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Mekke Joost M, Sakkers Tim R, Verwer Maarten C, van den Dungen Noortje A M, Song Yipei, Miller Clint L, Finn Aloke V, Pasterkamp Gerard, Mokry Michal, den Ruijter Hester M, Vink Aryan, de Kleijn Dominique P V, de Borst Gert J, Haitjema Saskia, van der Laan Sander W Dec 2023, In: Scientific Reports. 13 15 p.

Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis

Buono Michele F, Benavente Ernest Diez, Slenders Lotte, Methorst Daisey, Tessels Daniëlle, Mili Eloi, Finger Roxy, Kapteijn Daniek, Daniels Mark, van den Dungen Noortje A M, Calis Jorg J A, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Pasterkamp Gerard, den Ruijter Hester M, Mokry Michal 27 Oct 2023, In: Journal of the American Heart Association. 12

Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions

Kawai Kenji, Sakamoto Atsushi, Mokry Michal, Ghosh Saikat Kumar B, Kawakami Rika, Xu Weili, Guo Liang, Fuller Daniela, Tanaka Takamasa, Shah Palak, Cornelissen Anne, Sato Yu, Mori Masayuki, Konishi Takao, Vozenilek Aimee E, Dhingra Roma, Virmani Renu, Pasterkamp Gerard, Finn Aloke V 26 Oct 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 2333-2347 15 p.

Sex differences in the genetic and molecular mechanisms of coronary artery disease

Sakkers Tim R, Mokry Michal, Civelek Mete, Erdmann Jeanette, Pasterkamp Gerard, Diez Benavente Ernest, den Ruijter Hester M 5 Oct 2023, In: Atherosclerosis. 384

Colchicine promotes atherosclerotic plaque stability independently of inflammation

Li Weizhen, Lin Alexander, Hutton Michael, Dhaliwal Harkirat, Nadel James, Rodor Julie, Tumanov Sergey, Örd Tiit, Hadden Matthew, Mokry Michal, Mol Barend M, Pasterkamp Gerard, Padula Matthew P, Geczy Carolyn L, Ramaswamy Yogambha, Sluimer Judith C, Kaikkonen Minna U, Stocker Roland, Baker Andrew H, Fisher Edward A, Patel Sanjay, Misra Ashish 3 Oct 2023, 22 p.

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Kavousi Maryam et al. 28 Sep 2023, In: Nature Genetics. 55 , p. 1651-1664 14 p.

Proteomic Atlas of Atherosclerosis:The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

Theofilatos Konstantinos, Stojkovic Stefan, Hasman Maria, van der Laan Sander W, Baig Ferheen, Barallobre-Barreiro Javier, Schmidt Lukas, Yin Siqi, Yin Xiaoke, Burnap Sean, Singh Bhawana, Popham Jude, Harkot Olesya, Kampf Stephanie, Nackenhorst Maja Carina, Strassl Andreas, Loewe Christian, Demyanets Svitlana, Neumayer Christoph, Bilban Martin, Hengstenberg Christian, Huber Kurt, Pasterkamp Gerard, Wojta Johann, Mayr Manuel 30 Aug 2023, In: Circulation research. 133 , p. 542-558 17 p.

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques

Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Björkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 17 Aug 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 1836-1850 15 p.

X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

Buono Michele F, Benavente Ernest Diez, Daniels Mark, Mol Barend M, Mekke Joost M, de Borst Gert J, de Kleijn Dominique P V, van der Laan Sander W, Pasterkamp Gerard, Onland-Moret Charlotte, Mokry Michal, den Ruijter Hester M 5 Jul 2023, In: Biology of Sex Differences. 14 12 p.

Author Correction:The power of genetic diversity in genome-wide association studies of lipids (Nature, (2021), 600, 7890, (675-679), 10.1038/s41586-021-04064-3)

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 26 May 2023, In: Nature. 618 , p. E19-E20

All research output

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