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prof. dr. R.M. (Raymond) Schiffelers

prof. dr. R.M. (Raymond) Schiffelers

Full Professor

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Research Output (183)

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Bevers Sanne, Kooijmans Sander A A, Van de Velde Elien, Evers Martijn J W, Seghers Sofie, Gitz-Francois Jerney J J M, van Kronenburg Nicky C H, Fens Marcel H A M, Mastrobattista Enrico, Hassler Lucie, Sork Helena, Lehto Taavi, Ahmed Kariem E, El Andaloussi Samir, Fiedler Katja, Breckpot Karine, Maes Michael, Van Hoorick Diane, Bastogne Thierry, Schiffelers Raymond M, De Koker Stefaan 11 Jul 2022, In: Molecular Therapy. 30 , p. 3078-3094 17 p.

Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM 2.5 )-induced cardiac dysfunction via ACE2 signalling.

Wang Hongyun, Wang Tianhui, Rui Wei, Xie Jinxin, Xie Yuling, Zhang Xiao, Guan Longfei, Li Guoping, Lei Zhiyong, Schiffelers Raymond M, Sluijter Joost P G, Xiao Junjie May 2022, In: Journal of Extracellular Vesicles. 11 , p. 1-20

Utilizing in vitro drug release assays to predict in vivo drug retention in micelles

Varela-Moreira Aida, van Leur Heleen, Krijgsman Danielle, Ecker Veronika, Braun Martina, Buchner Maike, Fens Marcel H A M, Hennink Wim E, Schiffelers Raymond M 25 Apr 2022, In: International Journal of Pharmaceutics. 618

A robust post-insertion method for the preparation of targeted siRNA LNPs

Swart L E, Koekman C A, Seinen C W, Issa H, Rasouli M, Schiffelers R M, Heidenreich O 11 Apr 2022, In: International Journal of Pharmaceutics. 620 , p. 1-11

VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow

van Moorsel Marc V A, Poolen Geke, Koekman Cornelis A, Verhoef Sandra, de Maat Steven, Barendrecht Arjan, van Kleef Nadine D, Meijers Joost C M, Schiffelers Raymond, Maas Coen, Urbanus Rolf T 16 Feb 2022, In: Journal of thrombosis and haemostasis : JTH. 20 , p. 1213-1222 10 p.

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Evers Martijn J W, Du Wenjuan, Yang Qiangbing, Kooijmans Sander A A, Vink Arjan, van Steenbergen Mies, Vader Pieter, de Jager Saskia C A, Fuchs Sabine A, Mastrobattista Enrico, Sluijter Joost P G, Lei Zhiyong, Schiffelers Raymond 22 Jan 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343 , p. 207-216 10 p.

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement

Senti Mariona Estape, de Jongh Caroline A., Dijkxhoorn Kim, Verhoef Johan J. F., Szebeni Janos, Storm Gert, Hack C. Erik, Schiffelers Raymond M., Fens Marcel H., Boross Peter 7 Dec 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 341 , p. 475-486 12 p.

Themed issue:Extracellular vesicles in drug delivery and bioengineering

Fuhrmann Gregor, Lehr Claus-Michael, Schiffelers Raymond 1 Dec 2021, In: Advanced Drug Delivery Reviews. 181

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

van Haren Matthijs J, Gao Yongzhi, Buijs Ned, Campagna Roberto, Sartini Davide, Emanuelli Monica, Mateuszuk Lukasz, Kij Agnieszka, Chlopicki Stefan, Escudé Martinez de Castilla Pol, Schiffelers Raymond, Martin Nathaniel I 14 Sep 2021, In: Biomolecules. 11

Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Kooijmans Sander A A, de Jong Olivier G, Schiffelers Raymond M Jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 252-278 27 p.

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