prof. dr. R.M. (Raymond) Schiffelers

prof. dr. R.M. (Raymond) Schiffelers

Full Professor
prof. dr. R.M. (Raymond) Schiffelers
  • Department of Clinical Chemistry and Haematology



Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.


Side Activities

Without remuneration

Vice-president European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board Anjurium BioSciences

Member Scientific Advisory Board SentryX 



Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release


Part-time employment

Nanocell Therapeutics BV

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

Research Output (161)

Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

Kooijmans Sander A A, de Jong Olivier G, Schiffelers Raymond M jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 252-278 27 p.

Preface Special Issue (Sung Wan Kim memorial, Journal of Controlled Release)

Grainger David W, Hennink Wim, Schiffelers Raymond, Bae You Han 10 apr 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 332 , p. 592-593 2 p.

Natural or Synthetic RNA Delivery:A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Murphy Daniel E, de Jong Olivier G, Evers Martijn J W, Nurazizah Maratussholikhah, Schiffelers Raymond M, Vader Pieter 11 feb 2021, In: Nano letters. 21 , p. 1888-1895 8 p.

Polymeric delivery systems for nucleic acid therapeutics:Approaching the clinic

van den Berg Annette I S, Yun Chae-Ok, Schiffelers Raymond M, Hennink Wim E 13 jan 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 331 , p. 121-141 21 p.

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma:Proof of Concept Studies

Connor Kate, Murray David W, Jarzabek Monika A, Tran Nhan L, White Kieron, Dicker Patrick, Sweeney Kieron J, O'Halloran Philip J, MacCarthy Brian, Shiels Liam P, Lodi Francesca, Lambrechts Diether, Sarkaria Jann N, Schiffelers Raymond M, Symons Marc, Byrne Annette T dec 2020, In: Cancers. 12 , p. 1-19 19 p.

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Varela-Moreira Aida, van Straten Demian, van Leur Heleen F, Ruiter Ruud W J, Deshantri Anil K, Hennink Wim E, Fens Marcel H A M, Groen Richard W J, Schiffelers Raymond M dec 2020, In: International Journal of Pharmaceutics: X. 2 9 p.

Complete Tumor Regression by Liposomal Bortezomib in a Humanized Mouse Model of Multiple Myeloma

Deshantri Anil K, Fens Marcel H A M, Ruiter Ruud W J, Metselaar Josbert M, Storm Gert, Mandhane Sanjay N, Graat Gerard H M, Lentjes Eef G W, Yuan Huipin, de Bruijn Joost D, Mutis Tuna, Martens Anton C M, Groen Richard W J, Schiffelers Raymond M okt 2020, In: HemaSphere. 4 , p. 1-4

Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro

Patras Laura, Fens Marcel H A M, Vader Pieter, Barendrecht Arjan, Sesarman Alina, Banciu Manuela, Schiffelers Raymond 1 sep 2020, In: International journal of molecular sciences. 21 21 p.

Cellular and Molecular Mechanism of Cardiac Regeneration:A Comparison of Newts, Zebrafish, and Mammals

de Wit Lousanne, Fang Juntao, Neef Klaus, Xiao Junjie, A Doevendans Pieter, Schiffelers Raymond M, Lei Zhiyong, Sluijter Joost P G 19 aug 2020, In: Biomolecules. 10 20 p.

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

Francia Valentina, Schiffelers Raymond M, Cullis Pieter R, Witzigmann Dominik 7 aug 2020, In: Bioconjugate Chemistry. 31 , p. 2046-2059 14 p.

All research output

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