prof. dr. R.M. (Raymond) Schiffelers

prof. dr. R.M. (Raymond) Schiffelers

Full Professor
prof. dr. R.M. (Raymond) Schiffelers
  • Central Diagnostic Laboratory

Research Programs



Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.


Side Activities

Without remuneration

President European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles & Drug Delivery and Translational Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board Anjarium BioSciences

Member Scientific Advisory Board SentryX bv 



Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release


Part-time employment

Nanocell Therapeutics BV

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

Research Output (183)

mRNA delivery systems for cancer immunotherapy:Lipid nanoparticles and beyond

Estapé Senti Mariona, García Del Valle Lucía, Schiffelers Raymond M 1 Feb 2024, In: Advanced Drug Delivery Reviews. 206 , p. 1-17 17 p.

Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Fang Juntao, Yang Qiangbing, Maas Renée G C, Buono Michele, Meijlink Bram, Lotgerink Bruinenberg Dyonne, Benavente Ernest Diez, Mokry Michal, van Mil Alain, Qian Li, Goumans Marie-José, Schiffelers Raymond, Lei Zhiyong, Sluijter Joost P G 17 Jan 2024, In: Stem Cell Research & Therapy [E]. 15 , p. 19

Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes

Ilahibaks Nazma F, Kluiver Thomas A, de Jong Olivier G, de Jager Saskia C A, Schiffelers Raymond M, Vader Pieter, Peng Weng Chuan, Lei Zhiyong, Sluijter Joost P G Jan 2024, In: Journal of Extracellular Vesicles. 13

Heparin interferes with the uptake of liposomes in glioma

van Solinge Thomas S, Friis Kristina Pagh, O'Brien Killian, Verschoor Romy L, van Aarle Jeroen, Koekman Arnold, Breakefield Xandra O, Vader Pieter, Schiffelers Raymond, Broekman Marike 15 Dec 2023, In: International Journal of Pharmaceutics: X. 6 , p. 1-8

Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

Zeng Ye, Estapé Senti Mariona, Labonia M. Clara I., Papadopoulou Panagiota, Brans Maike A.D., Dokter Inge, Fens Marcel H., van Mil Alain, Sluijter Joost P.G., Schiffelers Raymond M., Vader Pieter, Kros Alexander 12 Dec 2023, In: ACS Nano. 17 , p. 23466-23477 12 p.

Cellular polyploidy in organ homeostasis and regeneration

Fang Juntao, de Bruin Alain, Villunger Andreas, Schiffelers Raymond, Lei Zhiyong, Sluijter Joost P G 1 Aug 2023, In: Protein & cell. 14 , p. 560-578 19 p.

Levodopa-loaded nanoparticles for the treatment of Parkinson's disease

van Vliet Emile F, Knol Maarten J, Schiffelers Raymond M, Caiazzo Massimiliano, Fens Marcel H A M 24 Jun 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 360 , p. 212-224 13 p.

Nanomedicines:An approach to treat placental insufficiency and the current challenges

van Kammen C M, van Woudenberg S J, Schiffelers R, Terstappen F, Lely A T 20 Jun 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 360 , p. 57-68 12 p.

Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles

Swart Laura E, Fens Marcel H A M, van Oort Anita, Waranecki Piotr, Mata Casimiro L Daniel, Tuk David, Hendriksen Martijn, van den Brink Luca, Schweighart Elizabeth, Seinen Cor, Nelson Ryan, Krippner-Heidenreich Anja, O'Toole Tom, Schiffelers Raymond M, Kooijmans Sander, Heidenreich Olaf Jun 2023, In: Pharmaceutics. 15 , p. 1-16

TOP-EVs:Technology of Protein delivery through Extracellular Vesicles is a versatile platform for intracellular protein delivery

Ilahibaks Nazma F., Ardisasmita Arif I., Xie Songpu, Gunnarsson Anders, Brealey Joseph, Vader Pieter, de Jong Olivier G., de Jager Saskia, Dekker Niek, Peacock Ben, Schiffelers Raymond M., Sluijter Joost P.G., Lei Zhiyong Mar 2023, In: Journal of Controlled Release. 355 , p. 579-592 14 p.

All research output

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