prof. dr. R.M. (Raymond) Schiffelers

Full Professor

  • Department of Clinical Chemistry and Haematology

prof. dr. R.M. (Raymond) Schiffelers


Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles, and Founder of EXCYTEX-an extracellular vesicle-based company.

Side Activities

  • Without remuneration

    Vice-president European Technology Platform Nanomedicine

    Associate Editor Journal of Extracellular Vesicles

    Associate Editor Pharmaceutical Research

    Founder/Share holder (<5%)/Scientific Advisor Excytex bv

    Member Scientific Advisory Board 20MED Therapeutics

    Member Scientific Advisory Board EtheRNA

    Member Scientific Advisory Board Anjurium

    Member Scientific Advisory Board SentryX bv

    Chairman NWO-STW Vidi-selection committee 2014-2015


    Remuneration for department

    Editor International Journal Pharmaceutics

    Editor Journal Controlled Release

Fellowship and Awards

  • Vidi 2007 ‘Targeting inflammation to fight cancer’

    Galenus Research Award 2009

    ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

    ERC Proof of Concept grant 2012 29744 ‘TargetMV’

Research Output (141)

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Varela-Moreira Aida, van Straten Demian, van Leur Heleen F, Ruiter Ruud W J, Deshantri Anil K, Hennink Wim E, Fens Marcel H A M, Groen Richard W J, Schiffelers Raymond M dec 2020, In: International Journal of Pharmaceutics: X. 2 9 p.

Nanocarrier-based drug combination therapy for glioblastoma

Zhao Mengnan, van Straten Demian, Broekman Marike L. D., Preat Veronique, Schiffelers Raymond M. 1 jan 2020, In: Theranostics. 10 , p. 1355-1372 18 p.

Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization

de Matos Maria B. C., Deckers Roe, van Elburg Benjamin, Lajoinie Guillaume, de Miranda Barbara S., Versluis Michel, Schiffelers Raymond, Kok Robbert J. 5 dec 2019, In: Frontiers in Pharmacology. 10

A head-to-head comparison of conjugation methods for VHHs:Random maleimide-thiol coupling versus controlled click chemistry

van Moorsel Marc V.A., Urbanus Rolf T., Verhoef S., Koekman C. A., Vink Maurice, Vermonden T., Maas Coen, Pasterkamp Gerard, Schiffelers Raymond M. 1 dec 2019, In: International Journal of Pharmaceutics: X. 1

Development and characterization of liposomal formulation of bortezomib

Deshantri Anil K, Metselaar Josbert M, Zagkou Stavroula, Storm Gert, Mandhane Sanjay N, Fens Marcel H A M, Schiffelers Raymond M 1 dec 2019, In: International Journal of Pharmaceutics: X. 1

Tumor Seeding During Colonoscopy as a Possible Cause for Metachronous Colorectal Cancer

Backes Yara, Seerden Tom C.J., van Gestel Rosanne S.F.E., Kranenburg Onno, Ubink Inge, Schiffelers Raymond M., van Straten Demian, van der Capellen Malu S., van de Weerd Simone, de Leng Wendy W.J., Siersema Peter D., Offerhaus G. Johan A., Morsink Folkert H., Ramphal Winesh, Terhaar Sive Droste Jochiim, van Lent Anja U.G., Geesing Joost M.J., Vleggaar Frank P., Elias Sjoerd G., Lacle Miangela M., Moons Leon M.G. 1 nov 2019, In: Gastroenterology. 157 , p. 1222-1232.e4

Biofabrication of Cell-Derived Nanovesicles: A Potential Alternative to Extracellular Vesicles for Regenerative Medicine

Ilahibaks Nazma, Lei Zhiyong, Deshantri AK, Jiang L, Schiffelers Raymond, Vader Pieter, Sluijter Joost P.G., Mol Emma nov 2019, In: Cells. 8

Bacterial membrane vesicles as promising vaccine candidates

Jiang Linglei, Schinkel Michelle, van Essen Max, Schiffelers Raymond M 24 sep 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 145 , p. 1-6 6 p.

Interfering with endolysosomal trafficking enhances release of bioactive exosomes

Ortega Francisco G., Roefs Marieke T., de Miguel Perez Diego, Kooijmans Sander A., de Jong Olivier G., Sluijter Joost P., Schiffelers Raymond M., Vader Pieter 1 aug 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20

Red Blood Cells:Chasing Interactions

Pretini Virginia, Koenen Mischa H, Kaestner Lars, Fens Marcel H A M, Schiffelers Raymond M, Bartels Marije, Van Wijk Richard 31 jul 2019, In: Frontiers in Physiology. 10

All Research Output (141)