dr. ir. E. (Ewoud) Schuit

dr. ir. E. (Ewoud) Schuit

Associate Professor
dr. ir. E. (Ewoud) Schuit
  • Julius Center, dept. Epidemiology & Health Economics

Research Programs




Who am I?

I am an expert in discovering, testing, and applying novel study designs and analysis methods for patient-oriented clinical research. My work focuses on the development, validation, implementation, and evaluation of medical technology (e.g., clinical prediction models, diagnostic tests, and digital healthcare innovations) to direct individualized treatment and care decision-making.


Primary focus of research

Since 2016, my research has increasingly focused on individualized clinical decision-making in cancer treatment, with a strong emphasis on risk prediction models. My research achieved significant impact, including successful funding acquisition, scientific publications, and development of analytical scripts.


Past and current activities

I am the national senior methodologist responsible for the development, validation, updating and implementation of clinical models that predict treatment effectiveness and radiation-induced toxicity to guide radiotherapy strategies, e.g., proton therapy. In this internationally renowned and unique project, I supervise numerous clinical and methodological researchers. I collaborate closely with (inter)national stakeholders, inside the UMCU, e.g., Division of Imaging and Cancer, Data Science & AI labs, and outside, e.g., PMC, EORTC, NVRO, Zorginstituut Nederland, Zorgverzekeraars Nederland, and NFK. My methodological work directly impacts clinical practice in The Netherlands and beyond as it is directly applied in the clinical prediction models that are currently nationally and internationally used for model-based treatment decisions.

I currently lead a team of researchers on personalized prediction model-based treatment decisions in cancer patients, especially in radiotherapy. Since 2016, after my 2-year visit to Stanford University (personal NWO Rubicon grant; supervisor: Prof. John Ioannidis), I have gradually and successfully expanded my team via multiple successful grant applications, including from ZonMw (PI), Horizon 2020, and KWF (multiple). My expertise and visibility are evident from invitations to methodologically guide the introduction of proton therapy in the Netherlands (see above), to discuss with global leaders the future of personalized radiotherapy (Beyond QUANTEC meeting), and contribute to in-house initiatives like the Data Science & AI labs, particularly the AI methods lab. In addition to my team lead leadership role, I am the vice chair of the Methods of Epidemiological Research Team at the Julius Center (>25 researchers). My broad training, combining clinical epidemiology with biomedical engineering, allows me to effectively collaborate and connect team projects with ongoing initiatives. I actively seek collaboration within and outside the UMC Utrecht and encourage team members’ involvement. Team members consult me on strategic, career, methodological, and personal aspects, and weekly and occasional meetings are organized to discuss state-of-the-art methodology.

Additionally, I am an expert in the development (e.g., alternative RCT designs, including prediction-model based evaluation of radiotherapy techniques [WhyMBA project; PI], adaptive early phase trials [ONCODE-PACT project], learning healthcare systems [ETHMIRE project]) and application (e.g., traditional, and alternative RCT designs, and evidence syntheses methods) of novel methods to evaluate healthcare innovations. These innovations are notably medical devices, meaning I have MDR and IVDR expertise: I contributed to five emergency, Ministry of VWS commissioned landmark COVID-19 rapid antigen testing studies (leading to an invitation by the CCMO to construct IVDR guidance for medical ethical review committees) and evaluated >30 commercial healthcare innovations at THINC. (, including a cancer-related fatigue treatment app. My visibility and expertise have led to a senior advisor position for the nationwide network of Zorgevaluatie & Gepast Gebruik (ZE&GG).

My work has been published in high-impact journals (n=140 papers; cited >8000 times) and incorporated in clinical guidelines (see above). I contributed to >20 successful grant applications, of which most grants obtained in the last 5 years, including one as PI, were focused on (methodology relevant for) cancer research, e.g., KWF, Horizon 2020, ZonMw grants, accumulating to a total of over 20 million euros.


Future plans

In the coming years, my team and I will continue to lead global advancements in personalized treatment strategies in cancer. We will focus on developing and applying cutting-edge techniques in epidemiology, statistics, precision medicine (molecular diagnostics), and data science (e.g., AI) to further optimize clinical decision-making. 

Research Output (156)

Prediction of fetal and neonatal outcomes after preterm manifestations of placental insufficiency:systematic review of prediction models

Kleuskens D G, van Veen C M C, Groenendaal F, Ganzevoort W, Gordijn S J, van Rijn B B, Lely A T, Schuit E, Kooiman J 9 May 2023, In: Ultrasound in Obstetrics and Gynecology. 62 , p. 644-652 9 p.

Prediction of Radiation-Induced Parotid Gland–Related Xerostomia in Patients With Head and Neck Cancer:regeneration-weighted dose

van Rijn Dekker M I, van Luijk P, Schuit E, van der Schaaf A, Langendijk J A, Steenbakkers R J H M 6 May 2023, In: International journal of radiation oncology, biology, physics. 117 , p. 750-762 13 p.

Progestogen maintenance therapy for prolongation of pregnancy after an episode of preterm labour:A systematic review and meta-analysis

Breuking Sofie H, De Ruigh Annemijn A, Hermans Frederik J R, Schuit Ewoud, Combs C Andrew, de Tejada Begoña Martinez, Oudijk Martijn A, Mol Ben W, Pajkrt Eva 19 Apr 2023, In: BJOG - An International Journal of Obstetrics and Gynaecology. 130 , p. 1306-1316 11 p.

OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE):study protocol of a multicentre, retrospective cohort study

van de Meent Mette, Kleuskens Dianne G, Ganzevoort Wessel, Gordijn Sanne J, Kooi Elisabeth M W, Onland Wes, van Rijn Bas B, Duvekot Johannes J, Kornelisse René F, Al-Nasiry Salwan, Jellema Reint K, Knol H Marieke, Manten Gwendolyn T R, Mulder-de Tollenaer Susanne M, Derks Jan B, Groenendaal Floris, Bekker Mireille N, Schuit Ewoud, Lely A Titia, Kooiman Judith 17 Mar 2023, In: BMJ Open. 13

Consortium for the Study of Pregnancy Treatments (Co-OPT):An international birth cohort to study the effects of antenatal corticosteroids

Frier Emily M, Lin Chun, Reynolds Rebecca M, Allegaert Karel, Been Jasper V, Fraser Abigail, Gissler Mika, Einarsdóttir Kristjana, Florian Lani, Jacobsson Bo, Vogel Joshua P, Zoega Helga, Bhattacharya Sohinee, Krispin Eyal, Henning Pedersen Lars, Roberts Devender, Kuhle Stefan, Fahey John, Mol Ben W, Burgner David, Schuit Ewoud, Sheikh Aziz, Wood Rachael, Gyamfi-Bannerman Cynthia, Miller Jessica E, Duhig Kate, Lahti-Pulkkinen Marius, Hadar Eran, Wright John, Murray Sarah R, Stock Sarah J 2 Mar 2023, In: PLoS ONE.

Association between low fetal fraction in cell-free DNA screening and fetal chromosomal aberrations:A systematic review and meta-analysis

Becking Ellis C, Schuit Ewoud, van Baar de Knegt Sophie M E, Sistermans Erik A, Henneman Lidewij, Bekker Mireille N, Scheffer Peter G 2023, In: Prenatal Diagnosis. 43 , p. 838-853 16 p.

Antibiotic treatment of bacterial vaginosis to prevent preterm delivery:Systematic review and individual participant data meta-analysis

Klebanoff Mark A., Schuit Ewoud, Lamont Ronald F., Larsson Per Göran, Odendaal Hein J., Ugwumadu Austin, Kiss Herbert, Petricevic Ljubomir, Andrews William W., Hoffman Matthew K., Shennan Andrew, Seed Paul T., Goldenberg Robert L., Emel Lynda M., Bhandaru Vinay, Weiner Steven, Larsen Michael D. 2023, In: Paediatric and Perinatal Epidemiology. 37 , p. 239-251 13 p.

Applicability of European Society of Cardiology guidelines according to gross national income

van Dijk Wouter B, Schuit Ewoud, van der Graaf Rieke, Groenwold Rolf H H, Laurijssen Sara, Casadei Barbara, Roffi Marco, Abimbola Seye, de Vries Martine C, Grobbee Diederick E 18 Nov 2022, In: European heart journal. 44 , p. 598-607 10 p.

Diagnostic accuracy of SARS-CoV-2 rapid antigen self-tests in asymptomatic individuals in the Omicron period:a cross-sectional study

Venekamp Roderick P, Schuit Ewoud, Hooft Lotty, Veldhuijzen Irene K, van den Bijllaardt Wouter, Pas Suzan D, Zwart Vivian F, Lodder Esther B, Hellwich Marloes, Koppelman Marco, Molenkamp Richard, Wijers Constantijn Jh, Vroom Irene H, Smeets Leonard C, Nagel-Imming Carla R S, Han Wanda G H, van den Hof Susan, Kluytmans Jan AJW, van de Wijgert Janneke H M, Moons Karel G M 12 Nov 2022, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 29 , p. 391.e1-391.e7 7 p.

Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing:cross-sectional study

Schuit Ewoud, Venekamp Roderick P., Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Stohr Joep J.J.M., Lodder Esther B., Hellwich Marloes, Molenkamp Richard, Igloi Zsofia, Wijers Constantijn, Vroom Irene H., Nagel-Imming Carla R.S., Han Wanda G.H., Kluytmans Jan A.J.W., van den Hof Susan, van de Wijgert Janneke H.H.M., Moons Karel G.M. 24 Oct 2022, In: BMC Medicine. 20

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