dr. ir. E. (Ewoud) Schuit

dr. ir. E. (Ewoud) Schuit

Assistant Professor
dr. ir. E. (Ewoud) Schuit
  • Julius Center, dept. Epidemiology & Health Economics
  • Julius Center Research Program Methodology

Research Programs

Strategic Program Cancer



Who am I?

I am an expert in discovering, testing, and applying novel study designs and analysis methods for patient-oriented clinical research. My work focuses on the development, validation, implementation, and evaluation of medical technology (e.g., clinical prediction models, diagnostic tests, and digital healthcare innovations) to direct individualized treatment and care decision-making.


Primary focus of research

Since 2016, my research has increasingly focused on individualized clinical decision-making in cancer treatment, with a strong emphasis on risk prediction models. My research achieved significant impact, including successful funding acquisition, scientific publications, and development of analytical scripts.


Past and current activities

I am the national senior methodologist responsible for the development, validation, updating and implementation of clinical models that predict treatment effectiveness and radiation-induced toxicity to guide radiotherapy strategies, e.g., proton therapy. In this internationally renowned and unique project, I supervise numerous clinical and methodological researchers. I collaborate closely with (inter)national stakeholders, inside the UMCU, e.g., Division of Imaging and Cancer, Data Science & AI labs, and outside, e.g., PMC, EORTC, NVRO, Zorginstituut Nederland, Zorgverzekeraars Nederland, and NFK. My methodological work directly impacts clinical practice in The Netherlands and beyond as it is directly applied in the clinical prediction models that are currently nationally and internationally used for model-based treatment decisions.

I currently lead a team of researchers on personalized prediction model-based treatment decisions in cancer patients, especially in radiotherapy. Since 2016, after my 2-year visit to Stanford University (personal NWO Rubicon grant; supervisor: Prof. John Ioannidis), I have gradually and successfully expanded my team via multiple successful grant applications, including from ZonMw (PI), Horizon 2020, and KWF (multiple). My expertise and visibility are evident from invitations to methodologically guide the introduction of proton therapy in the Netherlands (see above), to discuss with global leaders the future of personalized radiotherapy (Beyond QUANTEC meeting), and contribute to in-house initiatives like the Data Science & AI labs, particularly the AI methods lab. In addition to my team lead leadership role, I am the vice chair of the Methods of Epidemiological Research Team at the Julius Center (>25 researchers). My broad training, combining clinical epidemiology with biomedical engineering, allows me to effectively collaborate and connect team projects with ongoing initiatives. I actively seek collaboration within and outside the UMC Utrecht and encourage team members’ involvement. Team members consult me on strategic, career, methodological, and personal aspects, and weekly and occasional meetings are organized to discuss state-of-the-art methodology.

Additionally, I am an expert in the development (e.g., alternative RCT designs, including prediction-model based evaluation of radiotherapy techniques [WhyMBA project; PI], adaptive early phase trials [ONCODE-PACT project], learning healthcare systems [ETHMIRE project]) and application (e.g., traditional, and alternative RCT designs, and evidence syntheses methods) of novel methods to evaluate healthcare innovations. These innovations are notably medical devices, meaning I have MDR and IVDR expertise: I contributed to five emergency, Ministry of VWS commissioned landmark COVID-19 rapid antigen testing studies (leading to an invitation by the CCMO to construct IVDR guidance for medical ethical review committees) and evaluated >30 commercial healthcare innovations at THINC. (, including a cancer-related fatigue treatment app. My visibility and expertise have led to a senior advisor position for the nationwide network of Zorgevaluatie & Gepast Gebruik (ZE&GG).

My work has been published in high-impact journals (n=140 papers; cited >8000 times) and incorporated in clinical guidelines (see above). I contributed to >20 successful grant applications, of which most grants obtained in the last 5 years, including one as PI, were focused on (methodology relevant for) cancer research, e.g., KWF, Horizon 2020, ZonMw grants, accumulating to a total of over 20 million euros.


Future plans

In the coming years, my team and I will continue to lead global advancements in personalized treatment strategies in cancer. We will focus on developing and applying cutting-edge techniques in epidemiology, statistics, precision medicine (molecular diagnostics), and data science (e.g., AI) to further optimize clinical decision-making. 

Research Output (151)

OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE):study protocol of a multicentre, retrospective cohort study

van de Meent Mette, Kleuskens Dianne G, Ganzevoort Wessel, Gordijn Sanne J, Kooi Elisabeth M W, Onland Wes, van Rijn Bas B, Duvekot Johannes J, Kornelisse René F, Al-Nasiry Salwan, Jellema Reint K, Knol H Marieke, Manten Gwendolyn T R, Mulder-de Tollenaer Susanne M, Derks Jan B, Groenendaal Floris, Bekker Mireille N, Schuit Ewoud, Lely A Titia, Kooiman Judith 17 Mar 2023, In: BMJ Open. 13

Consortium for the Study of Pregnancy Treatments (Co-OPT):An international birth cohort to study the effects of antenatal corticosteroids

Frier Emily M, Lin Chun, Reynolds Rebecca M, Allegaert Karel, Been Jasper V, Fraser Abigail, Gissler Mika, Einarsdóttir Kristjana, Florian Lani, Jacobsson Bo, Vogel Joshua P, Zoega Helga, Bhattacharya Sohinee, Krispin Eyal, Henning Pedersen Lars, Roberts Devender, Kuhle Stefan, Fahey John, Mol Ben W, Burgner David, Schuit Ewoud, Sheikh Aziz, Wood Rachael, Gyamfi-Bannerman Cynthia, Miller Jessica E, Duhig Kate, Lahti-Pulkkinen Marius, Hadar Eran, Wright John, Murray Sarah R, Stock Sarah J 2 Mar 2023, In: PLoS ONE.

Association between low fetal fraction in cell-free DNA screening and fetal chromosomal aberrations:A systematic review and meta-analysis

Becking Ellis C, Schuit Ewoud, van Baar de Knegt Sophie M E, Sistermans Erik A, Henneman Lidewij, Bekker Mireille N, Scheffer Peter G 2023, In: Prenatal Diagnosis. 43 , p. 838-853 16 p.

Applicability of European Society of Cardiology guidelines according to gross national income

van Dijk Wouter B, Schuit Ewoud, van der Graaf Rieke, Groenwold Rolf H H, Laurijssen Sara, Casadei Barbara, Roffi Marco, Abimbola Seye, de Vries Martine C, Grobbee Diederick E 18 Nov 2022, In: European heart journal. 44 , p. 598-607 10 p.

Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing:cross-sectional study

Schuit Ewoud, Venekamp Roderick P., Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Stohr Joep J.J.M., Lodder Esther B., Hellwich Marloes, Molenkamp Richard, Igloi Zsofia, Wijers Constantijn, Vroom Irene H., Nagel-Imming Carla R.S., Han Wanda G.H., Kluytmans Jan A.J.W., van den Hof Susan, van de Wijgert Janneke H.H.M., Moons Karel G.M. 24 Oct 2022, In: BMC Medicine. 20

Comparison of new bronchopulmonary dysplasia definitions on long-term outcomes in preterm infants

Katz Trixie A, van Kaam Anton H, Schuit Ewoud, Mugie Suzanne M, Aarnoudse-Moens Cornelieke S H, Weber Elske H, de Groof Femke, van Laerhoven Henriette, Counsilman Clare E, van der Schoor Sophie R D, Rijpert Maarten, Schiering Irene A, Wilms Janneke, Leemhuis Aleid G, Onland Wes 20 Sep 2022, In: The Journal of Pediatrics. 253 , p. 86-93.e4

Diagnostic accuracy of covid-19 rapid antigen tests with unsupervised self-sampling in people with symptoms in the omicron period:cross sectional study

Schuit Ewoud, Venekamp Roderick P., Hooft Lotty, Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Zwart Vivian F., Lodder Esther B., Hellwich Marloes, Koppelman Marco, Molenkamp Richard, Wijers Constantijn J.H., Vroom Irene H., Smeets Leonard C., Nagel-Imming Carla R.S., Han Wanda G.H., van den Hof Susan, Kluytmans Jan A.J.W., van de Wijgert Janneke H.H.M., Moons Karel G.M. 14 Sep 2022, In: BMJ (Clinical research ed.). 378

When is it impractical to ask informed consent?:A systematic review

Laurijssen Sara Jm, van der Graaf Rieke, van Dijk Wouter B, Schuit Ewoud, Groenwold Rolf Hh, Grobbee Diederick E, de Vries Martine C 1 Jul 2022, In: Clinical Trials. 19 , p. 545-560 16 p.

2,109 randomized oncology trials map continuous, meager improvements in progression-free and overall survival over 50 years

Parish Austin J, Alina-Cristea Ioana, Schuit Ewoud, Ioannidis John P A 28 Jun 2022, In: Journal of Clinical Epidemiology. 150 , p. 106-115 10 p.

Timing of Delivery for Twins With Growth Discordance and Growth Restriction:An Individual Participant Data Meta-analysis

Koch Ashlee K, Burger Renée J, Schuit Ewoud, Mateus Julio Fernando, Goya Maria, Carreras Elena, Biancolin Sckarlet E, Barzilay Eran, Soliman Nancy, Cooper Stephanie, Metcalfe Amy, Lodha Abhay, Fichera Anna, Stagnati Valentina, Kawamura Hiroshi, Rustico Maria, Lanna Mariano, Munim Shama, Russo Francesca Maria, Nassar Anwar, Rode Line, Lim Arianne, Liem Sophie, Grantz Katherine L, Hack Karien, Combs C Andrew, Serra Vicente, Perales Alfredo, Khalil Asma, Liu Becky, Barrett Jon, Ganzevoort Wessel, Gordijn Sanne J, Morris R Katie, Mol Ben W, Li Wentao Jun 2022, In: Obstetrics and Gynecology. 139 , p. 1155-1167 13 p.

All research output

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