prof. dr. J.P.G. (Joost) Sluijter

prof. dr. J.P.G. (Joost) Sluijter

Full Professor
prof. dr. J.P.G. (Joost) Sluijter
  • Department of Experimental Cardiology



Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is nucleus member of the ESC working groups Cellular Biology of the Heart and Cardiovascular Regenerative & Reparative Medicine, has several editorial roles for journals, published >200 papers, and is awardee of an ERC consolidator grant.

Side Activities

  • Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology) 2010 - current

  • Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2016-2018
  • Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2018-2020

  • Nucleus member working group on Cardiovascular Regenerative & Reparative Medicine (European Society of Cardiology) 2020 - current

  • Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology) 2018-2020

  • Associate editor of Journal of Cardiovascular Translational Research 2016 - current

  • Associate Editor Discovery Biology and Medicine 2012-2014

  • Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)   2020 - current                                

  • Editorial Board member of Non-coding RNA Investigation 2018 - current

  • Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

  • Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

  • Member of the evaluation team for Ludwig Boltzman Institute for Cardiovascular Research, Vienna, September 2019.
  • Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

  • University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

  • Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship

  • 2007-2009 Novartis Foundation for Cardiovascular Excellence Grant

  • 2008-2009 van Ruyvenstichting: 

  • 2009-2012 UMC Utrecht focus and mass area “cardiovascular research”

  • 2010-2014 BMM-YIC

  • 2011-2015 Translationeel Adult Stamcelonderzoek:

  • 2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)

  • 2014-2018 LSH Impuls: MIGRATE

  • 2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration

  • 2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)

  • 2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy

  • 2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair

  • 2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”

  • 2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 

  • 2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 

  • 2019-2024: RegMed XB Cardiovascular Moonshot 

  • 2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)

  • 2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation.

  • 2021-2024: NWO-OTP - HARVEY; Heart vector-mediated gene therapy: towards a clinically applicable cure for inherited cardiomyopathies.

  • 2021-2024: ZonMw - PSIDER - Multi-disciplimaire Consortia: From pluripotent stem cells to prime editing gene therapy for inherited cardiomyopathies.

  • 2022-2026: Horizon-HLTH-2021-TOOL-06-02; HEAL - HLA-homozygous IPSC-cardiomyocyte aggregate manufacturing technologies for allogenic cell therapy to the heart.


Research Output (326)

Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia

Loen Vera, Smoczynska Agnieszka, Hernandez Alfonso Aranda, Scheerder Coert O S, van der Linde Britt H R, Beekman Henriëtte D M, Cervera-Barea Aina, Boink Gerard J J, Sluijter Joost P G, van der Heyden Marcel A G, Meine Mathias, Vos Marc A 1 Nov 2023, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 25

Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative

Balducci Valentina, Scardigli Francesco, Harakalova Magdalena, Peter. van Tintelen J., Doevendans Pieter A., Costa Kevin D., Turnbull Irene C., P. G. Sluijter Joost, Stillitano Francesca Oct 2023, In: Stem Cell Research. 72

Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

Van De Wakker Simonides Immanuel, Meijers Fleur Michelle, Sluijter Joost Petrus Gerardus, Vader Pieter Sep 2023, In: Pharmacological Reviews. 75 , p. 1043-1061 19 p.

Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins

Roefs Marieke Theodora, Bauzá-Martinez Julia, van de Wakker Simonides Immanuel, Qin Jiabin, Olijve Willem Theodoor, Tuinte Robin, Rozeboom Marjolein, Snijders Blok Christian, Mol Emma Alise, Wu Wei, Vader Pieter, Sluijter Joost Petrus Gerardus 1 Aug 2023, In: Communications biology. 6

Cellular polyploidy in organ homeostasis and regeneration

Fang Juntao, de Bruin Alain, Villunger Andreas, Schiffelers Raymond, Lei Zhiyong, Sluijter Joost P G 1 Aug 2023, In: Protein & cell. 14 , p. 560-578 19 p.

Harnessing developmental cues for cardiomyocyte production

Maas Renee G.C., van den Dolder Floor W., Yuan Qianliang, van der Velden Jolanda, Wu Sean M., Sluijter Joost P.G., Buikema Jan W. Aug 2023, In: Development (Cambridge). 150

Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform

Bracco Gartner Tom C.L., Wang Ye, Leiteris Laurynas, van Adrichem Iris, Marsman Judith, Goumans Marie José, Bouten Carlijn V.C., Sluijter Joost P.G., den Toonder Jaap M.J., Suyker Willem J.L., Hjortnaes Jesper Aug 2023, In: Journal of the mechanical behavior of biomedical materials. 144 13 p.

Convergence of melt electrowriting and extrusion-based bioprinting for vascular patterning of a myocardial construct

Ainsworth Madison Jade, Chirico Nino, de Ruijter Mylène, Hrynevich Andrei, Dokter Inge, Sluijter Joost P.G., Malda Jos, van Mil Alain, Castilho Miguel 1 Jul 2023, In: Biofabrication. 15

Cold Oxygenated Machine Perfusion Improves Functional Survival of Slaughterhouse Porcine Hearts

Kaffka Genaamd Dengler Selma E, Mishra Mudit, van Tuijl Sjoerd, de Jager Saskia C A, Sluijter Joost P G, Doevendans Pieter A, van der Kaaij Niels P 8 May 2023, In: ASAIO journal. 69 , p. 774-781 8 p.

The circadian clock remains intact, but with dampened hormonal output in heart failure

Crnko Sandra, Printezi Markella I., Zwetsloot Peter Paul M., Leiteris Laurynas, Lumley Andrew I., Zhang Lu, Ernens Isabelle, Jansen Tijn P.J., Homsma Lilian, Feyen Dries, van Faassen Martijn, du Pré Bastiaan C., Gaillard Carlo A.J.M., Kemperman Hans, Oerlemans Marish I.F.J., Doevendans Pieter A.F.M., May Anne M., Zuithoff Nicolaas P.A., Sluijter Joost P.G., Devaux Yvan, van Laake Linda W. May 2023, In: EBioMedicine. 91

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not