dr. H.T. (E) Spierings

dr. H.T. (E) Spierings

Associate Professor
dr. H.T. (E) Spierings
  • Central Diagnostic Laboratory



Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Side Activities

  • Associate editor: Frontiers in Immunology ( Section Alloimmunity and Transplantation)
  • Editorial Board: HLA
  • Editorial board: Cellular Immunology
  • Co-chair for the 18th International HLA & Immunogenetics Workshop (
  • Co-chair for the 35th Conference of the European Federation for Immunogenetics
  • Chair of the Bio-informatics Committee of the European Federation for Immunogenetics
  • Head of the Matchis Expertise Center, Leiden, The Netherlands

Fellowship and Awards

  • 1997: KNAW van Walree Grant
  • 2002: Best Abstract Award – 13th International Histocompatibility Workshop Conference 
  • 2004: Special Fellow – Leukemia and Lymphoma Society 
  • 2007: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2009: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2013: Ureka Mega Challenge Award for Innovation – UMC Utrecht
  • 2016: Novartis Award for best scientific publication – Dutch Transplantation Society
  • 2017: Medical Immunology Science Award – Dutch Society for Immunology

Research Output (120)

The Effect of Genetic HLA Matching on Liver Transplantation Outcome:A Systematic Review and Meta-Analysis

Kok Gautam, Ilcken Eveline F, Houwen Roderick H J, Lindemans Caroline A, Nieuwenhuis Edward E S, Spierings Eric, Fuchs Sabine A Sep 2023, In: Annals of surgery open : perspectives of surgical history, education, and clinical approaches. 4 , p. 1-7

World Marrow Donor Association guidelines for the reporting of novel HLA alleles

Hofmann Jan A, Bochtler Werner, Robinson James, Sauter Jürgen, Askar Medhat, Houdova Lucie, Melchers Mark, Schmidt Alexander H, Spierings Eric, Urban Christine, Venter Alicia, Maiers Martin, Marsh Steven G E, Eberhard Hans-Peter 10 Apr 2023, In: HLA. 102 , p. 62-64 3 p.

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

Mijnheer Gerdien, Servaas Nila Hendrika, Leong Jing Yao, Boltjes Arjan, Spierings Eric, Chen Phyllis, Lai Liyun, Petrelli Alessandra, Vastert Sebastiaan, de Boer Rob J, Albani Salvatore, Pandit Aridaman, van Wijk Femke 23 Jan 2023, In: eLife. 12

Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop

Matern Benedict M., Niemann Matthias, Nemparis Ioannis, Schimanski Andreas, Peereboom Emma T.M., Kramer Cynthia S.M., Heidt Sebastiaan, Spierings Eric 2023, In: HLA. 101 , p. 484-495 12 p.

Snowflake epitope matching correlates with child-specific antibodies during pregnancy and donor-specific antibodies after kidney transplantation

Niemann Matthias, Strehler Yara, Lachmann Nils, Halleck Fabian, Budde Klemens, Hönger Gideon, Schaub Stefan, Matern Benedict M, Spierings Eric 28 Oct 2022, In: Frontiers in Immunology. 13

The number of donor HLA-derived T cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation

Betjes Michiel G.H., Peereboom Emma T.M., Otten Henny G., Spierings Eric 30 Aug 2022, In: Frontiers in Immunology. 13

Snowflake:A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility

Niemann Matthias, Matern Benedict M, Spierings Eric 29 Jul 2022, In: Frontiers in Immunology. 13

The Value of Single-cell Technologies in Solid Organ Transplantation Studies

Peereboom Emma T M, Matern Benedict M, Spierings Eric, Geneugelijk Kirsten 25 Jul 2022, In: Transplantation. 106 , p. 2325-2337 13 p.

Assessment of human leukocyte antigen matching algorithm PIRCHE-II on liver transplantation outcomes

Kok Gautam, Verstegen Monique Ma, Houwen Roderick Hj, Nieuwenhuis Edward Es, Metselaar Herold J, Polak Wojciech G, van der Laan Luc Jw, Spierings Eric, den Hoed Caroline M, Fuchs Sabine A 25 Apr 2022, In: Liver Transplantation. 28 , p. 1356-1366 11 p.

HLA-DQ Heterodimers in Hematopoietic-Cell Transplantation

Petersdorf Effie W, Bengtsson Mats, Horowitz Mary M, McKallor Caroline, Spellman Stephen R, Spierings Eric, Gooley Theodore A, Stevenson Philip A 10 Mar 2022, In: Blood. 139 , p. 3009-3017 9 p.

All research output

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