dr. M.A.G. (Marcel) van der Heyden

dr. M.A.G. (Marcel) van der Heyden

Associate Professor
dr. M.A.G. (Marcel) van der Heyden
  • Department of Medical Physiology

Research Programs

Circulatory Health



Marcel is associate professor in the department of Medical Physiology at the University Medical Center Utrecht, The Netherlands. He obtained his PhD in the field of cancer research at the Utrecht University in 1995. Thereafter he performed two post-docs on stem cell biology and connexins at the Netherlands Institute of Developmental Biology. He entered the field of cardiac arrhythmias in 2000.
Currently, his focus is on cardiac potassium ion channel pharmacology and ion channel trafficking. His research group combines functional electrophysiological methods with cellular and molecular biology, and biochemical methods. He authored more than 120 peer reviewed papers, most of which deal with membrane protein biology and pharmacology including ion channels. 

Marcel teaches and writes on scientific integrity and is member of several advisory panels on this subject. Marcel is associate editor on four peer review physiology journals and was secretary of the Dutch Society of Physiology for five years. In 2017/18 he worked as guest-professor at the Department of Pharmacology and Toxicology at Vienna University. Marcel is a passionate teacher of physiology. He obtained his Senior Teaching Qualification in 2018 and is currently coordinator and examiner in the Medical curriculum in the course Circulation 1 and the bachelor Honours Program for medical students.



Cardiac physiology

Potassium ion channels

Cardiac arrhythmia

Ion channel trafficking

Scientific integrity

Research Output (160)

Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia

Loen Vera, Smoczynska Agnieszka, Hernandez Alfonso Aranda, Scheerder Coert O S, van der Linde Britt H R, Beekman Henriëtte D M, Cervera-Barea Aina, Boink Gerard J J, Sluijter Joost P G, van der Heyden Marcel A G, Meine Mathias, Vos Marc A 1 Nov 2023, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 25

IKs Activator ML277 Mildly Affects Repolarization and Arrhythmic Outcome in the CAVB Dog Model.

van Bavel Joanne J A, Beekman Henriëtte D M, Smoczyńska Agnieszka, van der Heyden Marcel A G, Vos Marc A 11 Apr 2023, In: Biomedicines. 11 11 p.

Pro-Arrhythmic Potential of Accumulated Uremic Toxins Is Mediated via Vulnerability of Action Potential Repolarization

van Ham Willem B, Cornelissen Carlijn M, Polyakova Elizaveta, van der Voorn Stephanie M, Ligtermoet Merel L, Monshouwer-Kloots Jantine, Vos Marc A, Bossu Alexandre, van Rooij Eva, van der Heyden Marcel A G, van Veen Toon A B 11 Mar 2023, In: International Journal of Molecular Sciences. 24

Chronic Propafenone Application Increases Functional K IR2.1 Expression In Vitro.

Li Encan, Kool Willy, Woolschot Liset, van der Heyden Marcel A G 7 Mar 2023, In: Pharmaceuticals. 16

Remodeling in the AV block dog is essential for tolerating moderate treadmill activity

van Bavel Joanne J.A., Beekman Henriëtte D.M., Schot Arend, Wouters Philippe C., van Emst Maarten G., Takken Tim, van der Heyden Marcel A.G., Vos Marc A. Feb 2023, In: IJC Heart and Vasculature. 44

Review of Case Reports on Adverse Events Related to Pre-workout Supplements Containing Synephrine

de Jonge M L L, Kieviet L C, Sierts M, Egberink L B, van der Heyden M A G Jan 2023, In: Cardiovascular Toxicology. 23 , p. 1-9 9 p.

I<sub>Ks</sub> inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog

van Bavel Joanne J.A., Beekman Henriëtte D.M., van Weperen Valerie Y.H., van der Linde Henk J., van der Heyden Marcel A.G., Vos Marc A. 15 Oct 2022, In: European Journal of Pharmacology. 932

PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

van Bavel J. J.A., Pham C., Beekman H. D.M., Houtman M. J.C., Bossu A., Sparidans R. W., van der Heyden M. A.G., Vos M. A. 3 Aug 2022, In: Frontiers in cardiovascular medicine. 9

Quantitative Analysis of the Cytoskeleton's Role in Inward Rectifier K IR 2.1 Forward and Backward Trafficking

Li Encan, Loen Vera, van Ham Willem B, Kool Willy, van der Heyden Marcel A G, Takanari Hiroki 25 Jan 2022, In: Frontiers in Physiology. 12 , p. 1-13

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome

Houtman Marien J C, Friesacher Theres, Chen Xingyu, Zangerl-Plessl Eva-Maria, van der Heyden Marcel A G, Stary-Weinzinger Anna 14 Jan 2022, In: Frontiers in Pharmacology. 12 , p. 1-15

All research output

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