prof. dr. P.J. (Paul) van Diest

prof. dr. P.J. (Paul) van Diest

Full Professor
prof. dr. P.J. (Paul) van Diest
  • Department of Pathology

Research Programs




Paul J van Diest has been a dedicated cancer researcher since the start of his career, obtaining numerous grants a.o. from the NIH and the Dutch Cancer Society. He studied Medicine, did his PhD and pathology residency at the VU University medical center (VUMC) in Amsterdam. After obtaining his Board certification in Pathology in 1996, he became Consultant Pathologist at the Department of Pathology of the VUMC. In 1999 he was appointed Associate Professor and in 2001 to full Professor. In 2003 he moved to Utrecht to become Head of the Department of Pathology at the University Medical Center Utrecht (UMCU) where he is currently still working. He is Adjunct Professor of Oncology at the Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA. He serves on the editorial board of >20 international journals. He has been active in the board as secretary and president of several international societies. He has published >900 papers in peer reviewed journals, personally supervised 87 PhD theses, and has an H-index of 97. The main theme of his research is finding ways for prevention, optimized diagnosis and cure of breast cancer, both the male and female forms. He is also active in the field of implementing digital pathology and AI.

Side Activities

From all these activitites for the UMC Utrecht  there never is personal income, or - if there is a fee - it is for the department of pathology of Utrecht.

Adjunct Professor of Oncology, Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA

Member of the Digital Pathology advisory board of PAIGE.

Editorial board activities

World Journal of Surgical Procedures      

Member of the Editorial Board of Recent Patents on Biomarkers

Member of the Editorial Board of the Chinese Journal of Clinicians

Associate editor of BMC Cancer

Member of the Editorial Board of Pathology Research International

Member of the Editorial Board of The Open Plastic Surgery Journal

Member of the Editorial Board of The Open Prostate Journal

Member of the Editorial Board of Laboratory Investigation

Member of the Editorial Board of the Journal of Experimental & Clinical Cancer Research

Member of the Editorial Board of Biotechnic and Histochemistry

Member of the Editorial Board of Analytical and Quantitative Cytology and Histology

Academic Editor of PlosOne

Associate editor of the Journal of Case Reports in Medicine

Member of the Editorial Board of World Journal of Medical Genetics

Member of the Editorial Board of World Journal of Clinical Urology

Member of the Editorial Board of World Journal of Surgical Procedures

Member of the Editorial Board of Current Biomarker Findings


Advisory boards


2005-               Member of the breast cancer advisory board of Astra Zenica

2008-               Member of the Digital Pathology advisory board of Philips.

2013-               Member of the Advisory Council of the Breast Cancer Society Netherlands (BVN)

2014-               Member of the advisory board of PathXL

2015-               Member of the advisory board of Sectra

Invited Speaker on (Inter)National Meetings 121 in 2003-2019: 1 only 2018-9 below for brevity reasons



  1. Sol Goldman Think-Tank Meeting on Artificial Intelligence as Applied to Pancreatic Cancer. Baltimore, MD, USA, April 16, 2018. Invited speaker.

  2. 11th joint meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland. Maastricht, The Netherlands, June 19-22 2018. Invited speaker.

  3. 30th European Congress of Pathology, Bilbao, Spain, September 8-12, 2018. Invited speaker.

  4. Hans Peterse Lecture at the NKI breast cancer symposium 2018. Amsterdam, The Netherlands, October 31, 2018. Invited speaker.

  5. Digital pathology in daily practice: The current status and the future. Utrecht, The Netherlands, November 2 2018. Organizer, speaker.

  6. 84th Annual Meeting of the Swiss Society of Pathology. Lugano, Switzerland, November 10, 2018. Invited speaker.




  7. European Congress of Radiology. Vienna, Austria, Febuary 27-March 3, 2019. Invited speaker.

  8. Artificial Intelligence in 2019: Where we are now. London UK, March 22, 2019. Invited speaker.

  9. 1e Wad 'n Workshop: Mammacarcinoom, Terschelling, The Netherlands, March 24-26. Invited speaker.

  10. European Working Group of Breast Screening Pathologists. Dublin, Ireland, March 29 2019. Invited speaker.

  11. Pathology week. Veenendaal, The Netherlands, April 9-12. Invited speaker.

  12. 5th Digital Pathology & AI congress: USA. NYC, NY, USA. June 13-14, 2019. Invited speaker

Yearly lectures 

1 NVvO Dutch Society of Oncology

2 ODDP, Oncology Drug Development in Practice

3 University of Siena

Contract research

OncoMark Ltd. Dublin, Ireland, Euro 15,000

Samantree Medical SA, Lausanne, Switzerland, Euro 18.000



"DDX3 as a biomarker for cancer and methods related thereto", in relation with Natsar Pharmaceuticals

Fellowship and Awards

Dutch Cancer Society (KWF)

Health Care Efficiency Research Programme of The Netherlands Organization for Health Research and Development (ZonMw)

Research Output (1024)

A comprehensive multi-domain dataset for mitotic figure detection

Aubreville Marc, Wilm Frauke, Stathonikos Nikolas, Breininger Katharina, Donovan Taryn A, Jabari Samir, Veta Mitko, Ganz Jonathan, Ammeling Jonas, van Diest Paul J, Klopfleisch Robert, Bertram Christof A Dec 2023, In: Scientific data. 10

Borstkanker tijdens en na de zwangerschap

Bakhuis Carsten F.J., Suelmann Britt B.M., van Dooijeweert Carmen, Moelans Cathy B., van der Wall Elsken, van Diest Paul J. 25 Oct 2023, In: Nederlands Tijdschrift voor Geneeskunde. 167

Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma:systematic review

Makineli Seher, van Wijnbergen Jan Willem M, Vriens Menno R, van Diest Paul J, Witkamp Arjen J 1 Aug 2023, In: BJS open. 7

A Second Ductoscopy Procedure in Patients with Recurrent and Persistent Pathological Nipple Discharge

Makineli Seher, Filipe Mando D., Vriens Menno R., Van Diest Paul, Witkamp Arjen J. 1 Aug 2023, In: Breast Care. 18 , p. 256-261 6 p.

R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling

Ter Steege Eline J, Doornbos Loes W, Haughton Peter D, van Diest Paul J, Hilkens John, Derksen Patrick W B, Bakker Elvira R M 1 Aug 2023, In: Cancer Letters. 568 , p. 1-10

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

Randolph Matthew E, Afifi Marwa, Gorthi Aparna, Weil Rachel, Wilky Breelyn A, Weinreb Joshua, Ciero Paul, Ter Hoeve Natalie, van Diest Paul J, Raman Venu, Bishop Alexander J R, Loeb David M 10 Jun 2023, p. 1-40

CONFIDENT-trial protocol:A pragmatic template for clinical implementation of artificial intelligence assistance in pathology

Flach Rachel N, Stathonikos Nikolas, Nguyen Tri Q, Ter Hoeve Natalie D, van Diest Paul J, van Dooijeweert Carmen 7 Jun 2023, In: BMJ Open. 13

Breast carcinoma detection in ex vivo fresh human breast surgical specimens using a fast slide-free confocal microscopy scanner:HIBISCUSS project

Conversano Angelica, Abbaci Muriel, van Diest Paul, Roulot Aurélie, Falco Giuseppe, Ferchiou Malek, Coiro Saverio, Richir Milan, Genolet Pierre-Michel, Clement Carine, Casiraghi Odile, Lahkdar Aicha Ben, Labaied Nizard, Ragazzi Moira, Mathieu Marie-Christine 1 Jun 2023, In: BJS open. 7

A whole-slide imaging based workflow reduces the reading time of pathologists

Baidoshvili Alexi, Khacheishvili Mariam, van der Laak Jeroen A.W.M., van Diest Paul J. Mar 2023, In: Pathology International. 73 , p. 127-134 8 p.

CT radiomics compared to a clinical model for predicting checkpoint inhibitor treatment outcomes in patients with advanced melanoma

Ter Maat Laurens S, van Duin Isabella A J, Elias Sjoerd G, Leiner Tim, Verhoeff Joost J C, Arntz Eran R A N, Troenokarso Max F, Blokx Willeke A M, Isgum Ivana, de Wit Geraldine A, van den Berkmortel Franchette W P J, Boers-Sonderen Marye J, Boomsma Martijn F, van den Eertwegh Fons J M, de Groot Jan Willem B, Piersma Djura, Vreugdenhil Art, Westgeest Hans M, Kapiteijn Ellen, van Diest Paul J, Pluim Josien P W, de Jong Pim A, Suijkerbuijk Karijn P M, Veta Mitko 24 Feb 2023, In: European Journal of Cancer. 185 , p. 167-177 11 p.

All research output

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