prof. dr. R. (Richard) van Hillegersberg

prof. dr. R. (Richard) van Hillegersberg

Full Professor
prof. dr. R. (Richard) van Hillegersberg
  • Department of Surgical Oncology

Research Programs

Strategic Program Cancer



Richard van Hillegersberg attended medical school in Rotterdam, the Netherlands. In 1990 he received a research grant from the Dutch Digestive Foundation, that enabled him to perform PhD research on the local treatment of liver metastases at the Department of Surgery, Erasmus MC in Rotterdam. In 1993 he received his PhD with honor. After obtaining his MD in 1994, he was a resident of Surgery in Rotterdam and was registered as general surgeon in 2000. From 2001-2002 he was a fellow of Surgical Oncology in the Academic Medical Center and Antoni van Leeuwenhoek Netherlands Cancer Center Amsterdam. Since 2003 he is appointed as staff surgeon at the University Medical Center Utrecht. From 2009 he is a full professor of gastrointestinal oncology and program leader of the GI-Oncology department. His clinical interests are upper gastrointestinal tract and hepatobiliary surgery. Research is focused on minimally invasive and robotic surgery, surgical imaging, genetic profiling and radiofrequency ablation for cancer. He has authored and co-authored over 200 articles in international peer-reviewed journals. He is past president of the Dutch GI Surgical Association, past board member of the Dutch Surgical Association, board member of the Dutch Society for liver surgery, president of the European Digestive Surgery, Chairman Dutch Upper GI Surgery Working Group and member of the permanent Scientific committee OESO World Organisation for Specialised studies on diseases of the esophagus.

Side Activities

Committee, board, editorial

2005 Board Member and Secretary of the Dutch Liver Surgery working group

2006 Editor of "Oncollectie"; News Facts on oncology and hematology

2009 Council member European Digestive Surgery

2009 Member Committee Dutch Guidelines oesophageal cancer, IKNL

2011 Board Member DUCA (Dutch UpperGI Cancer Audit)

2012 Editorial Board Member Journal of Gastroenterology and Hepatology Reasearch

2012 Scientific Advisory Committee MLD Stichting – Career Development Grant

2012 Chairman of MIRA special committee on robotic esophageal surgery

2013 Chairman Dutch Upper GI Surgery Working Group

2014 Board Member permanent Scientific committee OESO World Organisation for Specialised studies on diseases of the esophagus

2014 Board Member Technogolgy committee European Association for Endoscopic Surgery

2014 Editorial Board member Digestive Surgery

2015 EDS president elect. European Digestive Surgery


Visiting Professor Candiolo Institute Turin, 1 Jan 2019 → …

Proctor Intuitive Surgical, 1 Jan 2009 → …

Fellowship and Awards

1990-1992Principal investigator. Treatment of liver meatstases with laser, Erasmus University  Rotterdam. Project leader. Nederlandse Lever Darm Stichting (NLDS);  WS 89-14. Eu 120.000
1996-1998 Principal investigator. Ablation of Barrett'se oesophagus with photodynamic therapy after 5-aminolevulinic acid. Erasmus University Rotterdam. Nederlandse Lever Darm Stichting (NLDS);  WS 95-10. Eu 120.000
1995-1998 Principal investigator. Interstital lasercoagulation for liver metastases MRI thermography guided. Revolving Fund AZR. Eu 25.000
1996 Principal investigator. Short and long term outcome of interstitial laser coagulation with multiple fibers. Stichting Gastrostart. Eu 15.000
1998-2002 Principal investigator. Endovascular photodynamic therapy to prevent intimal hyperplasia after vascular interventions. Nederlandse Hartstichting (NHS) nr 97.181. Eu 250.000
2003-2007 Co-investigator. Is angiogenesis the key to more effective local treatment of liver metastases by interstitial thermal ablation? AGIKO project NWO. Eu 150.00
2003-2007 Co-investigator. Ischemia and reperfusion injury in the treatment of liver metastases. AGIKO project NWO. Eu 150.000
2003-2009 Co-investigator. Stategies to improve the outcome of esophagectomy in esophageal cancer. MDPhD project UMCU. Eu 120.000
2005-2009 Principal investigator. Local ablation of patients with T1 breast cancer. Unrestricted Grant Olympu. Eu 40.000
2005-2010 Principal investigator. Multicenter RCT HEPATICA studie. Hepatic resection followed by adjuvant treatment in colorectal liver metastases. Unrestricted Investigational grants van Sanofi-Aventis en Roche Eu 1.2000. CKTO KWF. WBSO subsidie(CX1T,2007). Eu 500.000
2006-2008  Principal investigator. RCT in Cytokine production related to desufflation of one lung in minimally invasive esophagectomy. IKMN bourse. Eu 20.000
2006-2011 Principal investigator. ZonW Multicenter gerandomiseerde trial “Radioguided occult lesion localisation in patients with non-palpable breast cancer. ZonMW en IKMN beurs (80-00702-98-037). Eu 383.000
2006-present  Principal investigator. Optimalisatie van imaging focale lever laesies.  Unrestricted Grant Beyer. Eu 120.000
2008-2009 Principal investigator. Esophagectomy: outcomes and perioperative course of esophageal cancer surgery. Unrestricted Grand Nycomed. Eu 20.000
2010–present Principal investigator. Radiofrequency ablation of locally advanced pancreatic cancer. NWO Mozaïek beurs. Eu 250.000
2011-present co-Principal investigator. Somatoststin for RFA of pancreatic cancer animal model studies. Unrestricted Grant Novartis. Eu 120.000
2012-present Principal investigator. Project non-colorectal liver metastases. NWO Mosaic beurs. Eu 250.000
2013-present Principal investigator. Radioembolization for Colorectal liver Metastases after Ablation. MDPhD Suerman program grant. Eu 100.000.
2014  European Society of Surgerical Oncology fellowship grant for fellow Aristoteles Kechagias, Greece, May 1,till July 1, 2014.
2014  Intuitive Surgery: Susanne van der Velden, fellow Robotchirurgie, Eu 75.000.
2014  Principal investigator. Cost effectiveness of laparoscopic gastrectomy  as an alternative to open gastrectomy for gastric cancer. ZonMw (837002502) Eu 400.000

Research Output (422)

Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN):study protocol for a randomized controlled trial

Walma M. S., Rombouts S. J., Brada L. J.H., Borel Rinkes I. H., Bosscha K., Bruijnen R. C., Busch O. R., Creemers G. J., Daams F., van Dam R. M., van Delden O. M., Festen S., Ghorbani P., de Groot D. J., de Groot J. W.B., Haj Mohammad N., van Hillegersberg R., de Hingh I. H., D’Hondt M., Kerver E. D., van Leeuwen M. S., Liem M. S., van Lienden K. P., Los M., de Meijer V. E., Meijerink M. R., Mekenkamp L. J., Nio C. Y., Oulad Abdennabi I., Pando E., Patijn G. A., Polée M. B., Pruijt J. F., Roeyen G., Ropela J. A., Stommel M. W.J., de Vos-Geelen J., de Vries J. J., van der Waal E. M., Wessels F. J., Wilmink J. W., van Santvoort H. C., Besselink M. G., Molenaar I. Q., dec 2021, In: Trials. 22 , p. 1-12

Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer

D'Journo Xavier Benoit, Boulate David, Fourdrain Alex, Loundou Anderson, van Berge Henegouwen Mark I, Gisbertz Suzanne S, O'Neill J Robert, Hoelscher Arnulf, Piessen Guillaume, van Lanschot Jan, Wijnhoven Bas, Jobe Blair, Davies Andrew, Schneider Paul M, Pera Manuel, Nilsson Magnus, Nafteux Philippe, Kitagawa Yuko, Morse Christopher R, Hofstetter Wayne, Molena Daniela, So Jimmy Bok-Yan, Immanuel Arul, Parsons Simon L, Larsen Michael Hareskov, Dolan James P, Wood Stephanie G, Maynard Nick, Smithers Mark, Puig Sonia, Law Simon, Wong Ian, Kennedy Andrew, KangNing Wang, Reynolds John V, Pramesh C S, Ferguson Mark, Darling Gail, Schröder Wolfgang, Bludau Marc, Underwood Tim, van Hillegersberg Richard, Chang Andrew, Cecconello Ivan, Ribeiro Ulysses, de Manzoni Giovanni, Rosati Riccardo, Kuppusamy MadhanKumar, Thomas Pascal Alexandre, Low Donald E, 1 sep 2021, In: JAMA Surgery. 156 , p. 836-845 10 p.

Overall Volume Trends in Esophageal Cancer Surgery Results From the Dutch Upper Gastrointestinal Cancer Audit

Voeten Daan M, Gisbertz Suzanne S, Ruurda Jelle P, Wilschut Janneke A, Ferri Lorenzo E, van Hillegersberg Richard, van Berge Henegouwen Mark I, 1 sep 2021, In: Annals of surgery. 274 , p. 449-458 10 p.

An in-silico assessment of the dosimetric benefits of MR-guided radiotherapy for esophageal cancer patients

Boekhoff Mick, Defize Ingmar, Borggreve Alicia, van Hillegersberg Richard, Kotte Alexis, Lagendijk Jan, van Lier Astrid, Ruurda Jelle, Takahashi Noriyoshi, Mook Stella, Meijer Gert sep 2021, In: Radiotherapy and Oncology. 162 , p. 76-84 9 p.

Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries:An international cohort study

Kamarajah S. K., Nepogodiev D., Bekele A., Cecconello I., Evans R. P.T., Guner A., Gossage J. A., Harustiak T., Hodson J., Isik A., Kidane B., Leon-Takahashi A. M., Mahendran H. A., Negoi I., Okonta K. E., Rosero G., Sayyed R. H., Singh P., Takeda F. R., van Hillegersberg R., Vohra R. S., White R. E., Griffiths E. A., Alderson D., Bundred J., Gossage J., Jefferies B., McKay S., Mohamed I., Siaw-Acheampong K., Vohra R., Wanigasooriya K., Whitehouse T., Gjata A., Moreno J. I., Guevara Castro R., Read M., Tan J. H., Matthijsen R., Ruurda J. P., van der Sluis P. C., de Maat M., Yildirim R., Wong V., Cox M., Mehta S., Kumar S., van Boxel Gijs, Athanasiou A., Singh A., , , , , jun 2021, In: European Journal of Surgical Oncology. 47 , p. 1481-1488 8 p.

CTV-to-PTV margin assessment for esophageal cancer radiotherapy based on an accumulated dose analysis

Boekhoff M R, Defize I L, Borggreve A S, van Hillegersberg R, Kotte A N T J, Lagendijk J J W, van Lier A L H M W, Ruurda J P, Takahashi N, Mook S, Meijer G J 14 mei 2021, In: Radiotherapy & Oncology. 161 , p. 16-22 7 p.

Supervised exercise after oesophageal cancer surgery:the PERFECT multicentre randomized clinical trial

van Vulpen J K, Hiensch A E, van Hillegersberg R, Ruurda J P, Backx F J G, Nieuwenhuijzen G A P, Kouwenhoven E A, Groenendijk R P R, van der Peet D L, Hazebroek E J, Rosman C, Wijnhoven B P L, van Berge Henegouwen Mark I, van Laarhoven H W M, Siersema PD, May A M 10 apr 2021, In: British Journal of Surgery. 108 , p. 786-796 11 p.

Expectations of Continuous Vital Signs Monitoring for Recognizing Complications After Esophagectomy:Interview Study Among Nurses and Surgeons

van Rossum Mathilde, Leenen Jobbe, Kingma Feike, Breteler Martine, van Hillegersberg Richard, Ruurda Jelle, Kouwenhoven Ewout, van Det Marc, Luyer Misha, Nieuwenhuijzen Grard, Kalkman Cor, Hermens Hermie 12 feb 2021, In: JMIR perioperative medicine. 4

Neoadjuvant Chemoradiotherapy Combined with Atezolizumab for Resectable Esophageal Adenocarcinoma:A Single Arm Phase II Feasibility Trial (PERFECT)

van den Ende Tom, Clercq Nicolien de, van Berge Henegouwen Mark I, UMC Amsterdam, Geijsen Debby, Verhoeven Rob, Meijer Sybren L, Schokker Sandor, Dings Mark, Bergman Jacques J G H M, Haj Mohammad Nadia, Ruurda Jelle P, van Hillegersberg Richard, Mook Stella, Nieuwdorp Max, de Gruijl Tanja D, Soeratram Tanya T D, Ylstra Bauke, van Grieken Nicole C T, Bijlsma Maarten F, Hulshof Maarten C C M, van Laarhoven Hanneke W 27 jan 2021, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 27 , p. 3351-3359 9 p.

Failure to Cure in Patients Undergoing Surgery for Gastric Cancer:A Nationwide Cohort Study

Voeten Daan M, van der Werf Leonie R, Wilschut Janneke A, Busweiler Linde A D, van Sandick Johanna W, van Hillegersberg Richard, van Berge Henegouwen Mark I, 23 jan 2021, In: Annals of Surgical Oncology. 28 , p. 4484-4496 13 p.

All research output

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