prof. dr. W.A. (Wilton) van Klei

prof. dr. W.A. (Wilton) van Klei

Full Professor
prof. dr. W.A. (Wilton) van Klei
  • Anesthesiology

Research Programs

Circulatory Health



Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht. Subsequently, he was the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht (2013-2021). Curently, his primary affiliation is at the University Health Network Toronto / University of Toronto, but he holds a small appointment as a research professor at the UMC Utrecht.


His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Side Activities

No side activities

Fellowship and Awards

2011 Research Award of the International Anesthesia Research Society (IARS)

Research Output (212)

Case 22-2023:A 59-Year-Old Woman with Hypotension and Electrocardiographic Changes

Van Klei Wilton A., Szabo Michele D., Hesterberg Paul E. 20 Jul 2023, In: New England Journal of Medicine. 389 , p. 263-272 10 p.

Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative:mortality, morbidity, and organ failure

Jackson Alexander I.R., Boney Oliver, Pearse Rupert M., Kurz Andrea, Cooper D. James, van Klei Wilton, Cabrini Luca, Miller Timothy E., Moonesinghe S. Ramani, Myles Paul, Grocott Michael P.W., Myles Paul, Gan T. J., Peyton Phil, Sessler Dan, Tramèr Martin, Cyna Alan, De Oliveira Gildasio S., Wu Christopher, Jensen Mark, Kehlet Henrik, Botti Mari, Haller Guy, Grocott Mike, Cook Tim, Fleisher Lee, Neuman Mark, Story David, Gruen Russell, Bampoe Sam, Evered Lis, Scott David, Silbert Brendan, van Dijk Diederik, Kalkman Cor, Chan Matthew, Grocott Hilary, Eckenhoff Rod, Rasmussen Lars, Eriksson Lars, Beattie Scott, Wijeysundera Duminda, Landoni Giovanni, Leslie Kate, Biccard Bruce, Howell Simon, Nagele Peter, Richards Toby, Dieleman Stefan, van Klei Wilton, Apr 2023, In: British Journal of Anaesthesia. 130 , p. 404-411 8 p.

Association of a Liberal Fasting Policy of Clear Fluids before Surgery with Fasting Duration and Patient Well-being and Safety

Marsman Marije, Kappen Teus H., Vernooij Lisette M., Van Der Hout Evelien C., Van Waes Judith A., Van Klei Wilton A. 8 Mar 2023, In: JAMA Surgery. 158 , p. 254-263 10 p.

Protocol ter preventie van perioperatieve pulmonale complicaties

Miggelbrink Lynn Ann, Marsman Marije, Senff Jasper R., van Waes Judith A.R., Bronsveld Inez, van Klei Wilton, Kappen Teus 20 Oct 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166

Associations between intraoperative hypotension, duration of surgery and postoperative myocardial injury after noncardiac surgery:a retrospective single-centre cohort study

Wesselink Esther M., Wagemakers Sjors H., van Waes Judith A.R., Wanderer Jonathan P., van Klei Wilton A., Kappen Teus H. Oct 2022, In: British Journal of Anaesthesia. 129 , p. 487-496 10 p.

Definitions of low cardiac output syndrome after cardiac surgery and their effect on the incidence of intraoperative LCOS:A literature review and cohort study

Schoonen Anna, van Klei Wilton A, van Wolfswinkel Leo, van Loon Kim 29 Sep 2022, In: Frontiers in cardiovascular medicine. 9

Outlying End-Tidal Carbon Dioxide During General Anesthesia Is Associated With Postoperative Pulmonary Complications:A Multicenter Retrospective Observational Study From US Hospitals Between 2010 and 2017

Akkermans Annemarie, Van Waes Judith A., Kheterpal Sachin, Pasma Wietze, Saager Leif, Thompson Aleda, Van Klei Wilton A. 1 Aug 2022, In: Anesthesia and Analgesia. 135 , p. 341-353 13 p.

Cochrane corner:Biomarkers to improve preoperative prediction of major cardiac outcomes after non-cardiac surgery

Vernooij Lisette M, van Klei Wilton A, Moons Karel Gm, van Waes Judith Ar, Damen Johanna Aag 5 Jul 2022, In: Heart (British Cardiac Society). 108 , p. 1257-1259 3 p.

Critical oxygen delivery threshold during cardiopulmonary bypass in older cardiac surgery patients with increased frailty risk

Smoor Rosa M., Van Dongen Eric P.A., Verwijmeren Lisa, Schreurs Inge A.A.M., Vernooij Lisette M., Van Klei Wilton A., Noordzij Peter G. 1 Mar 2022, In: European Journal of Cardio-thoracic Surgery. 61 , p. 685-692 8 p.

Preoperative frailty and one-year functional recovery in elderly cardiac surgery patients

Verwijmeren Lisa, Noordzij Peter G., Daeter Edgar J., Emmelot-Vonk Marielle H., Vernooij Lisette M., van Klei Wilton A., van Dongen Eric P.A. 2022, In: The Journal of Thoracic and Cardiovascular Surgery. 166 , p. 870-878.e6

All research output

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