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dr. J. (Jorg) van Loosdregt

dr. J. (Jorg) van Loosdregt

Associate Professor

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Research Output (45)

Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis

ter Haar Nienke M., Tak Tamar, Mokry Michal, Scholman Rianne C., Meerding Jenny M., de Jager Wilco, Verwoerd Anouk, Foell Dirk, Vogl Thomas, Roth Johannes, Leliefeld Pieter H.C., van Loosdregt Jorg, Koenderman Leo, Vastert Sebastiaan J., de Roock Sytze 1 Jan 2018, In: Arthritis and Rheumatology. 70 , p. 943-956 14 p.

Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells

Peeters Janneke G. C., de Graeff Nienke, Lotz Martin, Albani Salvatore, de Roock Sytze, van Loosdregt Jorg 1 Oct 2017, In: Rheumatology (Oxford, England). 56 , p. 1694-1699 6 p.

Update on research and clinical translation on specific clinical areas from biology to bedside:Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis

van Loosdregt Jorg, van Wijk Femke, Prakken Berent, Vastert Bas 1 Aug 2017, In: Best Practice and Research: Clinical Rheumatology. 31 , p. 460-475 16 p.

Enhancers in autoimmune arthritis:Implications and therapeutic potential

Peeters Janneke G. C., Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg 30 Jun 2017, In: Arthritis & Rheumatology. 69 , p. 1925–1936 12 p.

Increased autophagy in CD4(+) T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance

van Loosdregt Jorg, Rossetti Maura, Spreafico Roberto, Moshref Maryam, Olmer Merissa, Williams Gary W, Kumar Pavanish, Copeland Dana, Pischel Ken, Lotz Martin, Albani Salvatore Dec 2016, In: European Journal of Immunology. 46 , p. 2862-2870 9 p.

A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment

Spreafico Roberto, Rossetti Maura, van Loosdregt Jorg, Wallace Carol A, Massa Margherita, Magni-Manzoni Silvia, Gattorno Marco, Martini Alberto, Lovell Daniel J, Albani Salvatore Feb 2016, In: Annals of the Rheumatic Diseases. 75 , p. 459-465 7 p.

FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2

Fleskens V., Mokry M., van der Leun A. M., Huppelschoten S., Pals C. E G M, Peeters J., Coenen S., Cardoso B. A., Barata J. T., van Loosdregt J., Coffer P. J. 2016, In: Oncogene. 35 , p. 4141–4148 8 p.

Autoimmune disease-associated gene expression is reduced by BET-inhibition

Peeters Janneke G C, Vervoort Stephin J, Mijnheer Gerdien, de Roock Sytze, Vastert Sebastiaan J , Nieuwenhuis Edward E S, van Wijk Femke, Prakken Berent J, Mokry Michal, van Loosdregt Jorg 2016, In: Genomics data. 7 , p. 14-7 4 p.

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression

Peeters Janneke G C, Vervoort Stephin J, Tan Sander C, Mijnheer Gerdien, de Roock Sytze, Vastert Sebastiaan J. , Nieuwenhuis Edward E S, van Wijk Femke, Prakken Berent J, Creyghton Menno P, Coffer Paul J, Mokry Michal, van Loosdregt Jorg 29 Sep 2015, In: Cell Reports [E]. 12 , p. 1986-1996 11 p.

Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation

Bartels M, Govers Anita M., Fleskens Veerle, Lourenco Ana Rita, Pals Cornelieke E., Vervoort Stephin J., van Gent Rogier, Brenkman Arjan B., Bierings MB, Ackerman Steven J., van Loosdregt Jorg, Coffer Paul J. 12 Mar 2015, In: Blood. 125 , p. 1782-1792 11 p.

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