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dr. J. (Jorg) van Loosdregt

dr. J. (Jorg) van Loosdregt

Associate Professor

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Research Output (45)

Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region

Rossetti Maura, Spreafico Roberto, Saidin Suzan, Chua Camillus, Moshref Maryam, Leong Jing Yao, Tan York Kiat, Thumboo Julian, van Loosdregt Jorg, Albani Salvatore 1 Jan 2015, In: Journal of Immunology. 194 , p. 113-24 12 p.

Post-translational modification networks regulating FOXP3 function

van Loosdregt J., Coffer P.J 2014, In: Trends in immunology. 35 , p. 368-378 11 p.

A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples

Spreafico Roberto, Rossetti Maura, van den Broek Theo, Jansen Nicolaas J G, Zhang Hong, Moshref Maryam, Prakken Berent, van Loosdregt Jorg, van Wijk Femke, Albani Salvatore 2014, In: European Journal of Immunology. 44 , p. 3141-3143 3 p.

Canonical Wnt signaling negatively modulates regulatory T cell function

van Loosdregt J., Fleskens V., Tiemessen M.M., Mokry M., van Boxtel R., Meerding J.M., Pals C.E.G.M., Kurek D., Baert M.R., Delemarre E.M., Grone A., Groot Koerkamp M.J.A., Sijts E.J.A.M., Nieuwenhuis E.E.S., Maurice M.M., van Es J.H., Ten Berge D, Holstege F.C.P., Staal F.J., Zaiss D.M.W., Prakken A.B.J., Coffer P.J 2013, In: Immunity. 39 , p. 298-310 13 p.

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor.

Zaiss D.M.W., van Loosdregt J., Gorlani A., Bekker C.P.J., Gröne A., Sibilia M., van Bergen en Henegouwen P.M.P., Roovers R.C., Coffer P.J, Sijts E.J.A.M. 2013, In: Immunity. 38 , p. 275-284 10 p.

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

van Loosdregt J., Fleskens V., Fu J., Brenkman A.B., Bekker C.P.J., Pals C.E.G.M., Meerding J.M., Berkers C.R., Barbi J., Grone A., Sijts E.J.A.M., Maurice M.M., Kalkhoven E., Prakken A.B.J., Ovaa H., Pan F., Zaiss D.M.W., Coffer P.J 2013, In: Immunity. 39 , p. 259-271 13 p.

Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.

van Loosdregt J., Spreafico R., Rossetti M., Prakken A.B.J., Lotz M., Albani S. 2013, In: Journal of Allergy and Clinical Immunology. 131 , p. 1443-1446 4 p.

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

Gao Y., Koppen A., Rakhshandehroo M., Tasdelen I., van de Graaf S.F.J., van Loosdregt J., van Beekum O., Hamers N., van Leenen D., Berkers C.R., Berger R., Holstege F.C.P., Coffer P.J, Brenkman A.B., Ovaa H., Kalkhoven E. 2013, In: Nature Communications [E]. 4 , p. 2656 1 p.

Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output

Beekman J.M., Vervoort S.J., Dekkers F.J., van Vessem M.E., Vendelbosch S., Brugulat-Panes A., van Loosdregt J., Braat A.K., Coffer P.J 2012, In: Oncogene. 31 , p. 2668-2679 12 p.

Post-translational regulation of Foxp3 : identification of novel molecular targets for immune modulation

van Loosdregt J. 8 Jun 2011, 163 p.

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