prof. dr. S.W.C. van Mil

prof. dr. S.W.C. van Mil

Full Professor
prof. dr. S.W.C. van Mil
  • Center for Molecular Medicine



Saskia van Mil (PhD) is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, and Director of the Center for Molecular Medicine ( She is a member of the governing board and scientific committee of the European Association for the Study of the Liver (
She received her PhD from the University of Utrecht in 2004, on the topic of genetic disorders of pediatric cholestasis. As a post-doc at Imperial College London, United Kingdom, she studied the role of the bile salt sensor farnesoid X receptor (FXR) in intrahepatic cholestasis of pregnancy.
Since then, she has been intrigued by the versatility in molecular mechanisms of transcription by the nuclear receptor FXR and its therapeutic potential. Having received funding from the Netherlands’ Organisation of Scientific Research (Veni, Vidi, Vici), European Commission, Dutch Digestive Disease Foundation and DSM, her group studies the molecular and translational aspects of energy metabolism in the liver and the intestine. Amongst other projects, her group studies the molecular mechanisms of FXR function in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD). For more information on her research, please visit 

Side Activities

2020-2023 Governing Board and Scientific Committee member of the European Association for the Study of the Liver

Research Output (49)

Multi-country metabolic signature discovery for chicken health classification

Wolthuis Joanna C., Magnúsdóttir Stefanía, Stigter Edwin, Tang Yuen Fung, Jans Judith, Gilbert Myrthe, van der Hee Bart, Langhout Pim, Gerrits Walter, Kies Arie, de Ridder Jeroen, van Mil Saskia 2 Feb 2023, In: Metabolomics. 19

Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids

de Wit Koos, Beuers Ulrich, Mukha Anna, Stigter Edwin, Gulersonmez M Can, Ramos Pittol Jose M, Middendorp Sabine, Takkenberg R Bart, van Mil Saskia W C 4 Dec 2022, In: Liver International. 43 , p. 649-659 11 p.

PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

Madsen Maria Stahl, Broekema Marjoleine F., Madsen Martin Rønn, Koppen Arjen, Borgman Anouska, Gräwe Cathrin, Thomsen Elisabeth G.K., Westland Denise, Kranendonk Mariette E.G., Koerkamp Marian Groot, Hamers Nicole, Bonvin Alexandre M.J.J., Pittol José M.Ramos, Natarajan Kedar Nath, Kersten Sander, Holstege Frank C.P., Monajemi Houshang, van Mil Saskia W.C., Vermeulen Michiel, Kragelund Birthe B., Cassiman David, Mandrup Susanne, Kalkhoven Eric Dec 2022, In: Nature Communications. 13

Protein Condensation in the Nuclear Receptor Family; Implications for Transcriptional Output

Appelman Monique D, Hollaar Elle E, Schuijers Jurian, van Mil Saskia W C 2022, p. 243-253 11 p.

Breast milk nutrients driving intestinal epithelial layer maturation via Wnt and Notch signaling:Implications for necrotizing enterocolitis

de Jong Judith C.W., Ijssennagger Noortje, van Mil Saskia W.C. 1 Nov 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867 , p. 1-9

Splice variants of metabolic nuclear receptors:Relevance for metabolic disease and therapeutic targeting

Mukha Anna, Kalkhoven Eric, van Mil Saskia W.C. 1 Oct 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867 , p. 1-13 13 p.

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Ijssennagger Noortje, van Rooijen Kristel S, Magnúsdóttir Stefanía, Ramos Pittol José M, Willemsen Ellen C L, de Zoete Marcel R, Baars Matthijs J D, Stege Paul B, Colliva Carolina, Pellicciari Roberto, Youssef Sameh A, de Bruin Alain, Vercoulen Yvonne, Kuipers Folkert, van Mil Saskia W C Oct 2021, In: JHEP reports : innovation in hepatology. 3 , p. 1-10

Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders

Appelman Monique D, van der Veen Suzanne W, van Mil Saskia W C 27 Sep 2021, In: Frontiers in Endocrinology. 12 , p. 1-13

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD:A systematic review and meta-analysis

Selvaraj Emmanuel Anandraj, Mózes Ferenc Emil, Jayaswal Arjun Narayan Ajmer, Zafarmand Mohammad Hadi, Vali Yasaman, Lee Jenny A., Levick Christina Kim, Young Liam Arnold Joseph, Palaniyappan Naaventhan, Liu Chang Hai, Aithal Guruprasad Padur, Romero-Gómez Manuel, Brosnan M. Julia, Tuthill Theresa A., Anstee Quentin M., Neubauer Stefan, Harrison Stephen A., Bossuyt Patrick M., Pavlides Michael, Anstee Quentin, Daly Ann, Johnson Katherine, Govaere Olivier, Cockell Simon, Tiniakos Dina, Bedossa Pierre, Oakley Fiona, Cordell Heather, Day Chris, Wonders Kristy, Bossuyt Patrick, Zafarmand Hadi, Lee Jenny, Ratziu Vlad, Clement Karine, Pais Raluca, Schuppan Detlef, Schattenberg Jörn, Vidal-Puig Toni, Vacca Michele, Rodrigues-Cuenca Sergio, Allison Mike, Kamzolas Ioannis, Petsalaki Evangelia, Oresic Matej, Hyötyläinen Tuulia, McGlinchey Aiden, Mato Jose M., Millet Oscar, van Mil Saskia, 2021, In: Journal of Hepatology. 75 , p. 770-785 16 p.

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

Ramos Pittol Jose Miguel, Milona Alexandra, Morris Imogen, Willemsen Ellen C L, van der Veen Suzanne W, Kalkhoven Eric, van Mil Saskia W C Nov 2020, In: Gastroenterology. 159 , p. 1853-1865.e10

All research output

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