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prof. dr. J.M. Beekman

prof. dr. J.M. Beekman

Full Professor

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Research Output (125)

Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression

Muilwijk Danya, de Poel Eyleen, van Mourik Peter, Suen Sylvia W F, Vonk Annelotte M, Brunsveld Jesse E, Kruisselbrink Evelien, Oppelaar Hugo, Hagemeijer Marne C, Berkers Gitte, de Winter-de Groot Karin M, Heida-Michel Sabine, Jans Stephan R, van Panhuis Hannah, van der Eerden Menno M, van der Meer Renske, Roukema Jolt, Dompeling Edward, Weersink Els J M, Koppelman Gerard H, Vries Robert, Zomer-van Ommen Domenique D, Eijkemans Marinus J C, van der Ent Cornelis K, Beekman Jeffrey M 27 Jan 2022, In: The European respiratory journal. 60 , p. 1-11

In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Rümke Lidewij W, Groenveld Femke C, van Os Yvonne M G, Praest Patrique, Tanja Anniek A N, de Jong Dorien T C M, Symons Jori, Schuurman Rob, Reinders Tessa, Hofstra L Marije, Nierkens Stefan, Thijsen Steven F T, Heron Michiel, Lebbink Robert-Jan, Beekman Jeffrey M, Nijhuis Monique, Wensing Annemarie M J Jan 2022, In: Open forum infectious diseases. 9 , p. 1-6

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators

Muilwijk Danya, Bierlaagh Marlou, van Mourik Peter, Kraaijkamp Jasmijn, van der Meer Renske, van den Bor Rutger, Heijerman Harry, Eijkemans René, Beekman Jeffrey, van der Ent Kors 16 Dec 2021, In: Journal of Personalized Medicine. 11 , p. 1-12

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

Geurts Maarten H., de Poel Eyleen, Pleguezuelos-Manzano Cayetano, Oka Rurika, Carrillo Léo, Andersson-Rolf Amanda, Boretto Matteo, Brunsveld Jesse E., van Boxtel Ruben, Beekman Jeffrey M., Clevers Hans Oct 2021, In: Life Science Alliance. 4

Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

de Poel E., Spelier S., Suen S. W.F., Kruisselbrink E., Graeber S. Y., Mall M. A., Weersink E. J.M., van der Eerden M. M., Koppelman G. H., van der Ent C. K., Beekman J. M. Oct 2021, In: Journal of Cystic Fibrosis. 21 , p. 246-253 8 p.

CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

de Poel Eyleen, Spelier Sacha, Korporaal Ricardo, Lai Ka Wai, Boj Sylvia F., Conrath Katja, van der Ent Cornelis K., Beekman Jeffrey M. 15 Sep 2021, In: Frontiers in Molecular Biosciences. 8

A new era for people with cystic fibrosis

Bierlaagh Marlou C., Muilwijk Danya, Beekman Jeffrey M., van der Ent Cornelis K. Sep 2021, In: European Journal of Pediatrics. 180 , p. 2731-2739 9 p.

Breast development in a 7 year old girl with CF treated with ivacaftor:An indication for personalized dosing?

Jeyaratnam Joshena, van der Meer Renske, Berkers Gitte, Heijerman Harry Gm, Beekman Jeffrey M, van der Ent Cornelis K 23 Jun 2021, In: Journal of Cystic Fibrosis. 20 , p. e63-e66

An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay

Hagemeijer Marne C., Vonk Annelotte M., Awatade Nikhil T., Silva Iris A.L., Tischer Christian, Hilsenstein Volker, Beekman Jeffrey M., Amaral Margarida D., Botelho Hugo M. 15 Dec 2020, In: Bioinformatics. 36 , p. 5686-5694 9 p.

Comparison of organoid swelling and in vivo biomarkers of cftr function to determine effects of lumacaftor-ivacaftor in patients with cystic fibrosis homozygous for the f508del mutation

Graeber Simon Y., van Mourik Peter, Vonk Annelotte M., Kruisselbrink Evelien, Hirtz Stephanie, van der Ent Cornelis K., Mall Marcus A., Beekman Jeffrey M. 1 Dec 2020, In: American Journal of Respiratory and Critical Care Medicine. 202 , p. 1589-1592 4 p.

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