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prof. dr. W.L. (Wouter) de Laat

prof. dr. W.L. (Wouter) de Laat

Full Professor

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Research Output (91)

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Redolfi Josef, Zhan Yinxiu, Valdes-Quezada Christian, Kryzhanovska Mariya, Guerreiro Isabel, Iesmantavicius Vytautas, Pollex Tim, Grand Ralph S, Mulugeta Eskeatnaf, Kind Jop, Tiana Guido, Smallwood Sebastien A, de Laat Wouter, Giorgetti Luca Jun 2019, In: Nature Structural and Molecular Biology. 26 , p. 471-480 10 p.

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Laarman Melanie D., Geeven Geert, Barnett Phil, Rinkel Gabriël J.E., de Laat Wouter, Ruigrok Ynte M., Bakkers Jeroen, 7 May 2019, In: Journal of the American Heart Association. 8

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

Monroe Tanner O., Hill Matthew C., Morikawa Yuka, Leach John P., Heallen Todd, Cao Shuyi, Krijger Peter H.L., de Laat Wouter, Wehrens Xander H.T., Rodney George G., Martin James F. 25 Mar 2019, In: Developmental Cell. 48 , p. 765-779.e7

Enhancer hubs and loop collisions identified from single-allele topologies

Allahyar Amin, Vermeulen Carlo, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, van Kranenburg Melissa, Pieterse Mark, Straver Roy, Haarhuis Judith H.I., Jalink Kees, Teunissen Hans, Renkens Ivo J., Kloosterman Wigard P., Rowland Benjamin D., de Wit Elzo, de Ridder Jeroen, de Laat Wouter 1 Aug 2018, In: Nature Genetics. 50 , p. 1151-1160 10 p.

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Gupta Rajat M., Hadaya Joseph, Trehan Aditi, Zekavat Seyedeh M., Roselli Carolina, Klarin Derek, Emdin Connor A., Hilvering Catharina R.E., Bianchi Valerio, Mueller Christian, Khera Amit V., Ryan Russell J.H., Engreitz Jesse M., Issner Robbyn, Shoresh Noam, Epstein Charles B., de Laat Wouter, Brown Jonathan D., Schnabel Renate B., Bernstein Bradley E., Kathiresan Sekar 27 Jul 2017, In: Cell. 170 , p. 522-533.e15

Small chromosomal regions position themselves autonomously according to their chromatin class

Van De Werken Harmen J.G., Haan Josien C., Feodorova Yana, Bijos Dominika, Weuts An, Theunis Koen, Holwerda Sjoerd J.B., Meuleman Wouter, Pagie Ludo, Thanisch Katharina, Kumar Parveen, Leonhardt Heinrich, Marynen Peter, van Steensel Bas, Voet Thierry, De Laat Wouter, Solovei Irina, Joffe Boris 1 Jun 2017, In: Genome Research. 27 , p. 922-933 12 p.

Can We Just Say:Transcription Second?

Krijger Peter Hugo Lodewijk, de Laat Wouter 6 Apr 2017, In: Cell. 169 , p. 184-185 2 p.

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

Dreijerink Koen M A, Groner Anna C., Vos Erica S M, Font-Tello Alba, Gu Lei, Chi David, Reyes Jaime, Cook Jennifer, Lim Elgene, Lin Charles Y., de Laat Wouter, Rao Prakash K., Long Henry W., Brown Myles 7 Mar 2017, In: Cell Reports [E]. 18 , p. 2359-2372 14 p.

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

Vermeulen Carlo, Geeven Geert, de Wit Elzo, Verstegen Marjon J A M, Jansen Rumo P.M., van Kranenburg Melissa, de Bruijn Ewart, Pulit Sara L., Kruisselbrink Evelien, Shahsavari Zahra, Omrani Davood, Zeinali Fatemeh, Najmabadi Hossein, Katsila Theodora, Vrettou Christina, Patrinos George P., Traeger-Synodinos Joanne, Splinter Erik, Beekman Jeffrey M., Kheradmand Kia Sima, Te Meerman Gerard J, Ploos van Amstel Hans Kristian, de Laat Wouter 2017, In: American Journal of Human Genetics. 101 , p. 326-339 14 p.

Regulation of disease-associated gene expression in the 3D genome

Krijger Peter Hugo Lodewijk, De Laat Wouter 21 Nov 2016, In: Nature reviews molecular cell biology. 17 , p. 771-782 12 p.

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