prof. dr. N.J. (Niek) de Wit

prof. dr. N.J. (Niek) de Wit

Full Professor
prof. dr. N.J. (Niek) de Wit



Niek de Wit has been working as a general practitioner for more than 25 years. In 2009 he was appointed as professor in General Practice at the University Medical Center in Utrecht, the Netherlands. From 2010 until July 2019 he has been manager of the Julius Health Centers, the academic general practice in Utrecht. Since June 2019 he is Division chair ad interim of the Julius Center of Health Sciences and Primary Care at the UMC Utrecht.


His research focus is on health care innovation, gastrointestinal disease and oncology in primary care. He is co-author of national and international guidelines on IBS, dyspepsia, diverticulitis and colorectal cancer. In the past years he has been involved in the development of a regional health care network , aiming at primary- hospital care collaboration, optimizing health care pathways and facilitating health care innovation initiatives in the Utrecht region.


From 2010-2012 he was visiting professor at Kings’ College, London, UK. From 2012 he is visiting professor at the University of Durham, UK , and in 2014 he was inaugurated as fellow of the Royal College of Physicians, Edinburg, UK.

Side Activities

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­Committees (unremunerated)

  • Member of the committee of Regional Innovation committee of the Dutch Association of Academic Hospitals (NFU) (since 2018)
  • Member of the prevention committee of the Dutch Association of Academic Hospitals (NFU) (since 2021)  
  • Chair, scientific commitee, Health Hub Utrecht (since 2020)        

National scientific advisory boards (unremunerated)

  • Member of the program committee ‘Quality of Care’ of the Netherlands Organisation of Health research and development (ZON MW) from 2013
  • Member of the scientific committee of the Dutch Cancer Society (since 2019)
  • Member of the Effective care (Doen of laten) program committee of the Netherlands Organisation of Health research and development (ZON MW) (since 2016)
  • Member of the advisory board of the Effective Care pathway (Zinnige Zorg) on Dyspepsia of the Dutch Health care Institute (ZIN) (since 2019)  

Guideline committees (unremunerated)

  • Member of professional guideline committees of the Dutch College of General Practice on dyspepsia (since 1992), IBS (since 2005) and diverticulitis (since 2009)
  • Member of the multidisciplinary guideline committee on Irritable Bowel Syndrome of the Dutch College of GP and Federation Medical Specialists (since 2009)

International scientific advisory boards (unremunerated)

  • Founding secretary and member of the steering committee of the European Society for Primary Care Gastroenterology (since 2007)
  • Member of the primary care committee of the Rome Foundation for Functional digestive disorders (since 2012)
  • Member of the international advisory board of the Norwegian Primary Care Practice based Research Network Praxisnett (since 2017)
  • International partner of the CANTEST research consortium for early diagnosis of cancer in primary care (since 2017)
  • Member of the international advisory board of the BMBF program on Primary Care research networks, Ministry of Health, Germany (since 2018)

Editorial Board (unremunerated)

  • Member of the editorial board of Family Practice (since 2004)
  • Member of the editorial board of Praktische Huisartsgeneeskunde (BSL) (since 2010)

Other societal activities (unremunerated)

  • Member of the supervisory board of the general practitioners organisation “RHOGO” Hilversum (since 2019)
  • Member of the supervisory board of the academic Hospice Demeter, de Bilt (since 2020)
  • Founding member of the ‘Dappere Dokters’ movement in Utrecht
  • Member of the Utrecht Development Board
  • Consultant for Program management advice for lwo and middle income countries (PUM),  Ministry of Economic affairs, the Hague

Research Output (380)

Low-dose amitriptyline in irritable bowel syndrome:ready for primary care?

de Wit Niek, Keszthelyi Daniel 16 Oct 2023, In: Lancet (London, England). 402 , p. 1727-1728 2 p.

Population-based impact of COVID-19 on incidence, treatment, and survival of patients with pancreatic cancer

Graus Merlijn U.J.E., de Hingh Ignace H.J.T., Besselink Marc G., Bruno Marco J., Wilmink Johanna W., de Meijer Vincent E., van Velthuysen Marie Louise F., Valkenburg-van Iersel Liselot B.J., van der Geest Lydia G.M., de Vos-Geelen Judith, Siesling S., van Hoeve J. C., Merkx M. A.W., de Wit N. J., Helsper C. W., Dingemans I., Nagtegaal I. D., van der Schaaf M., van Gils C. H., van Weert H. C.P.M., Verheij M., , , Oct 2023, In: HPB. 25 , p. 1195-1202 8 p.

Patients’ views on the decision to investigate cancer symptoms in older adults::a qualitative interview study in primary care

Jones Daniel, Ali Omer M., Honey Stephanie, Surr Claire, Scott Suzanne, De Wit Niek, Neal Richard D. Aug 2023, In: British Journal of General Practice. 73 , p. e597-e604

The cost-effectiveness of an indicated blended care intervention in primary care compared to usual care in patients with moderate persistent somatic symptoms

Toonders S A J, van Westrienen P E, de Wit N J, van Dongen J M, Gerrits M, Pisters M F, Veenhof C 26 May 2023, In: Journal of Psychosomatic Research. 171

Effectiveness of a blended multidisciplinary intervention for patients with moderate medically unexplained physical symptoms (PARASOL):A cluster randomized clinical trial

van Westrienen Paula Elisabeth, de Wit Niek, Toonders Suze, Veenhof Cindy, Gerrits Marloes, Pisters Martijn Apr 2023, In: PLoS ONE. 18

Impact of the COVID-19 Outbreak—Delayed Referral of Colorectal and Lung Cancer in Primary Care:A National Retrospective Cohort Study

Helsper Charles W., Van Gils Carla H., Van Erp Nicole F., Siepman van den Berg Marinde F.R., Rogouti Omar, Van Asselt Kristel M., Maarsingh Otto R., Muris Jean, Brandenbarg Daan, Siesling Sabine, De Wit Niek J., Grant Matthew P., 25 Feb 2023, In: Cancers. 15

Cluster analysis of functional independence in community-dwelling older people

Molenaar Esther A.L.M., Barten Di Janne Ja, de Hoop Anne M.S., Bleijenberg Nienke, de Wit Niek J., Veenhof Cindy Dec 2022, In: BMC Geriatrics. 22

Changes in breast cancer treatment during the COVID-19 pandemic:a Dutch population-based study

Eijkelboom Anouk H., de Munck Linda, Menke-van der Houven van Oordt C. Willemien, Broeders Mireille J.M., van den Bongard Desiree H.J.G., Strobbe Luc J.A., Mureau Marc A.M., Lobbes Marc B.I., Westenend Pieter J., Koppert Linetta B., Jager Agnes, Siemerink Ester J.M., Wesseling Jelle, Verkooijen Helena M., Vrancken Peeters Marie Jeanne T.F.D., Smidt Marjolein L., Tjan-Heijnen Vivianne C.G., Siesling Sabine, van Hoeve J. C., Merkx M. A.W., de Wit N. J., Dingemans I., Nagtegaal I. D., , 5 Nov 2022, In: Breast Cancer Research and Treatment. 197 , p. 161-175 15 p.

The Impact of the COVID Pandemic on the Incidence of Presentations with Cancer-Related Symptoms in Primary Care

Grant Matthew P, Helsper Charles W, Stellato Rebecca, van Erp Nicole, van Asselt Kristel M, Slottje Pauline, Muris Jean, Brandenbarg Daan, de Wit Niek J, van Gils Carla H 1 Nov 2022, In: Cancers. 14 , p. 1-12

Mental Health Morbidities and Time to Cancer Diagnosis Among Adults With Colon Cancer in England

Benitez Majano Sara, Lyratzopoulos Georgios, de Wit Niek J, White Becky, Rachet Bernard, Helsper Charles, Usher-Smith Juliet, Renzi Cristina 31 Oct 2022, In: JAMA network open. 5 , p. 1-15

All research output

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