prof. dr. D.W.J. Klomp
- 7T Group
Research Programs
Biography
Biography
Research interests
In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.
Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.
The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.
Side Activities
Non executive board member, Tesla, August 2019 - August 2050
Research Output (157)
Branderhorst Woutjan, Steensma Bart R., Beijst Casper, Huijing Erik R., Alborahal Cezar, Versteeg Edwin, Weissler Bjoern, Schug David, Gebhardt Pierre, Gross-Weege Nicolas, Mueller Florian, Krueger Karl, Dey Thomas, Radermacher Harald, Lips Oliver, Lagendijk Jan, Schulz Volkmar, de Jong Hugo W.A.M., Klomp Dennis W.J. apr 2021, In: Physics and Imaging in Radiation Oncology. 17 , p. 13-19 7 p.
Froeling Martijn, Prompers Jeanine J, Klomp Dennis W J, van der Velden Tijl A 1 feb 2021, In: Magnetic Resonance in Medicine. 85 , p. 2992-3009 18 p.
Gosselink Mark, Hoogduin Hans, Froeling Martijn, Klomp Dennis W J 2021, In: NMR in Biomedicine. 34
Versteeg Edwin, van der Velden Tijl A, van Leeuwen Carel C, Borgo Martino, Huijing Erik R, Hendriks Arjan D, Hendrikse Jeroen, Klomp Dennis W J, Siero Jeroen C W 2021, In: NMR in Biomedicine. 34 13 p.
Bhogal Alex A, Broeders Tommy A A, Morsinkhof Lisan, Edens Mirte, Nassirpour Sahar, Chang Paul, Klomp Dennis W J, Vinkers Christiaan H, Wijnen Jannie P 20 nov 2020, In: Brain and Behavior. 10 , p. 1-14
Steensma Bart, van de Moortele Pierre-Francois, Ertürk Arcan, Grant Andrea, Adriany Gregor, Luijten Peter, Klomp Dennis, van den Berg Nico, Metzger Gregory, Raaijmakers Alexander nov 2020, In: Magnetic Resonance in Medicine. 84 , p. 2885-2896 12 p.
van Rijssel Michael J., Pluim Josien P.W., Chan Hui Shan M., van den Wildenberg Lieke, Schmitz Alexander M.Th, Luijten Peter R., Gilhuijs Kenneth G.A., Klomp Dennis W.J. 1 aug 2020, In: Magnetic Resonance in Medicine. 84 , p. 1000-1010 11 p.
Xavier Aline, Arteaga de Castro Catalina, Andia Marcelo E, Luijten Peter R, Klomp Dennis W, Fillmer Ariane, Prompers Jeanine J aug 2020, In: NMR in Biomedicine. 33 14 p.
Annink K V, van der Aa N E, Dudink J, Alderliesten T, Groenendaal F, Lequin M, Jansen F E, Rhebergen K S, Luijten P, Hendrikse J, Hoogduin H J M, Huijing E R, Versteeg E, Visser F, Raaijmakers A J E, Wiegers E C, Klomp D W J, Wijnen J P, Benders M J N L 30 jul 2020, In: American Journal of Neuroradiology. 41 , p. 1532-1537 6 p.
Brinkhof Sander, Te Moller Nikae, Froeling Martijn, Brommer Harold, van Weeren René, Ito Keita, Klomp Dennis 3 jun 2020, In: Journal of Orthopaedic Research. 38 , p. 2383-2389 7 p.