prof. dr. D.W.J. Klomp
Full Professor
- 7T Group
Contact
Research Programs
Biography
Research interests
In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.
Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.
The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.
Side Activities
Non executive board member, Tesla, August 2019 - August 2050
Research Output (141)
Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T
van Rijssel Michael J., Pluim Josien P.W., Chan Hui Shan M., van den Wildenberg Lieke, Schmitz Alexander M.Th, Luijten Peter R., Gilhuijs Kenneth G.A., Klomp Dennis W.J. 1 aug 2020, In: Magnetic Resonance in Medicine. 84 , p. 1000-1010 11 p.
Pushing functional MRI spatial and temporal resolution further:High-density receive arrays combined with shot-selective 2D CAIPIRINHA for 3D echo-planar imaging at 7 T
Hendriks Arjan D, D'Agata Federico, Raimondo Luisa, Schakel Tim, Geerts Liesbeth, Luijten Peter R, Klomp Dennis W J, Petridou Natalia 3 mrt 2020, In: NMR in Biomedicine. 33 13 p.
Inherently decoupled H-1 antennas and P-31 loops for metabolic imaging of liver metastasis at 7 T
Rivera Debra, Kalleveen Irene, de Castro Catalina Arteaga, van Laarhoven Hanneke, Klomp Dennis, van der Kemp Wybe, Stoker Jaap, Nederveen Aart 10 jan 2020, In: NMR in Biomedicine. 33 10 p.
Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH
Khlebnikov Vitaliy, van der Kemp Wybe J. M., Hoogduin Hans, Klomp Dennis W. J., Prompers Jeanine J. 1 dec 2019, In: Scientific Reports. 9
Measurement of T<sub>1</sub> and T<sub>2</sub> relaxation times of the pancreas at 7 T using a multi-transmit system
Damen Mariska, van Leeuwen Maarten, Webb Andrew, Klomp Dennis, de Castro Catalina Arteaga 1 dec 2019, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 32 , p. 703-708 6 p.
Low SAR <sup>31</sup>P (multi-echo) spectroscopic imaging using an integrated whole-body transmit coil at 7T
van Houtum Q., Welting D., Gosselink W. J.M., Klomp D. W.J., Arteaga de Castro C. S., van der Kemp W. J.M. 1 dec 2019, In: NMR in Biomedicine. 32
Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI
Brinkhof S., Ali Haghnejad A., Ito K., Markenroth Bloch K., Klomp D. W.J. 1 nov 2019, In: NMR in Biomedicine. 32 , p. e4173
Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker
van der Kemp Wybe J.M., van der Velden Tijl A., Schmitz Alexander M., Gilhuijs Kenneth G., Luijten Peter R., Klomp Dennis W.J., Wijnen Jannie P. 1 okt 2019, In: NMR in Biomedicine. 32 , p. e4011
Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI
Krikken Erwin, van der Kemp Wybe J.M., Khlebnikov Vitaliy, van Dalen Thijs, Los Maartje, van Laarhoven Hanneke W.M., Luijten Peter R., van den Bosch Maurice A.A.J., Klomp Dennis W.J., Wijnen Jannie P. 1 aug 2019, In: NMR in Biomedicine. 32 , p. e4110
Methodological consensus on clinical proton MRS of the brain:Review and recommendations
Wilson Martin, Andronesi Ovidiu, Barker Peter B., Bartha Robert, Bizzi Alberto, Bolan Patrick J., Brindle Kevin M., Choi In Young, Cudalbu Cristina, Dydak Ulrike, Emir Uzay E., Gonzalez Ramon G., Gruber Stephan, Gruetter Rolf, Gupta Rakesh K., Heerschap Arend, Henning Anke, Hetherington Hoby P., Huppi Petra S., Hurd Ralph E., Kantarci Kejal, Kauppinen Risto A., Klomp Dennis W.J., Kreis Roland, Kruiskamp Marijn J., Leach Martin O., Lin Alexander P., Luijten Peter R., Marjańska Małgorzata, Maudsley Andrew A., Meyerhoff Dieter J., Mountford Carolyn E., Mullins Paul G., Murdoch James B., Nelson Sarah J., Noeske Ralph, Öz Gülin, Pan Julie W., Peet Andrew C., Poptani Harish, Posse Stefan, Ratai Eva Maria, Salibi Nouha, Scheenen Tom W.J., Smith Ian C.P., Soher Brian J., Tkáč Ivan, Vigneron Daniel B., Howe Franklyn A. 1 aug 2019, In: Magnetic Resonance in Medicine. 82 , p. 527-550 24 p.