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prof. dr. D.W.J. Klomp Full Professor

  • 7T Group

D.W.J. Klomp

Contact

Research Programs

Biography

Research interests

In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.

Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.

The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.

Side Activities

  • Non executive board member, Tesla, August 2019 - August 2050

Research Output (78)

Inherently decoupled H-1 antennas and P-31 loops for metabolic imaging of liver metastasis at 7 T

Rivera Debra, Kalleveen Irene, de Castro Catalina Arteaga, van Laarhoven Hanneke, Klomp Dennis, van der Kemp Wybe, Stoker Jaap, Nederveen Aart 10 jan 2020, In: NMR in Biomedicine. p. e4221

Measurement of T<sub>1</sub> and T<sub>2</sub> relaxation times of the pancreas at 7 T using a multi-transmit system

Damen Mariska, van Leeuwen Maarten, Webb Andrew, Klomp Dennis, de Castro Catalina Arteaga 1 dec 2019, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 32 , p. 703-708 6 p.

Low SAR <sup>31</sup>P (multi-echo) spectroscopic imaging using an integrated whole-body transmit coil at 7T

van Houtum Q., Welting D., Gosselink W. J.M., Klomp D. W.J., Arteaga de Castro C. S., van der Kemp W. J.M. 1 dec 2019, In: NMR in Biomedicine. 32

Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI

Brinkhof S., Ali Haghnejad A., Ito K., Markenroth Bloch K., Klomp D. W.J. 1 nov 2019, In: NMR in Biomedicine. 32 , p. e4173

Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker

van der Kemp Wybe J.M., van der Velden Tijl A., Schmitz Alexander M., Gilhuijs Kenneth G., Luijten Peter R., Klomp Dennis W.J., Wijnen Jannie P. 1 okt 2019, In: NMR in Biomedicine. 32 , p. e4011

Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI

Krikken Erwin, van der Kemp Wybe J.M., Khlebnikov Vitaliy, van Dalen Thijs, Los Maartje, van Laarhoven Hanneke W.M., Luijten Peter R., van den Bosch Maurice A.A.J., Klomp Dennis W.J., Wijnen Jannie P. 1 aug 2019, In: NMR in Biomedicine. 32 , p. e4110

Reducing distortions in echo-planar breast imaging at ultrahigh field with high-resolution off-resonance maps

van Rijssel Michael J, Zijlstra Frank, Seevinck Peter R, Luijten Peter R, Gilhuijs Kenneth G A, Klomp Dennis W J, Pluim Josien P W jul 2019, In: Magnetic Resonance in Medicine. 82 , p. 425-435 11 p.

Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy in breast cancer patients using phosphorus magnetic resonance spectroscopy at 7T

Krikken Erwin, van der Kemp Wybe J M, van Diest Paul J, van Dalen Thijs, van Laarhoven Hanneke W M, Luijten Peter R, Klomp Dennis W J, Wijnen Jannie P jun 2019, In: NMR in Biomedicine. 32

Comparison of four MR carotid surface coils at 3T

Zhang Qinwei, Coolen Bram F., van den Berg Sandra, Kotek Gyula, Rivera Debra S., Klomp Dennis W.J., Strijkers Gustav J., Nederveen Aart J. 1 mrt 2019, In: PLoS ONE. 14 , p. e0213107

Homogeneous B<sub>1 </sub><sup>+</sup> for bilateral breast imaging at 7 T using a five dipole transmit array merged with a high density receive loop array

Krikken Erwin, Steensma Bart R., Voogt Ingmar J., Luijten Peter R., Klomp Dennis W.J., Raaijmakers Alexander J.E., Wijnen Jannie P. feb 2019, In: NMR in Biomedicine. 32 , p. e4039

All Research Output (78)
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