dr. ir. J.J.M. Zwanenburg

dr. ir. J.J.M. Zwanenburg

Associate Professor
dr. ir. J.J.M. Zwanenburg
  • Research group Neurovascular Imaging



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant "Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)" (2013, ERC grant agreement n°337333).

Vici grant: "Seismology of the brain - A new approach for probing the brain’s microvasculature and tissue properties" (2021)

Research Output (155)

Detectability and accuracy of computational measurements of in-silico and physical representations of enlarged perivascular spaces from magnetic resonance images

Duarte Coello Roberto, Valdés Hernández Maria Del C, Zwanenburg Jaco J M, van der Velden Moniek, Kuijf Hugo J, De Luca Alberto, Moyano José Bernal, Ballerini Lucia, Chappell Francesca M, Brown Rosalind, Jan Biessels Geert, Wardlaw Joanna M Mar 2024, In: Journal of Neuroscience Methods. 403 11 p.

Atrial fibrillation hemodynamic effects on lenticulostriate arteries identified at 7-Tesla cerebral magnetic resonance imaging

Saglietto Andrea, Scarsoglio Stefania, Tripoli Francesco, Zwanenburg Jaco, Biessels Geert Jan, De Ferrari Gaetano Maria, Ridolfi Luca, Anselmino Matteo Sep 2023, In: Clinical and Translational Medicine [E]. 13

Abnormalities in cardiac-induced brain tissue deformations are now detectable with MRI:A case-report of a patient who underwent craniotomy after trauma

Sloots Jacob Jan, Biessels Geert Jan, Amelink G. Johan, Zwanenburg Jaco J.M. May 2023, In: Magnetic Resonance Imaging. 98 , p. 62-65 4 p.

Assessment of aortic and cerebral haemodynamics and vascular brain injury with 3 and 7 T magnetic resonance imaging in patients with aortic coarctation

Meijs Timion A., Van Tuijl Rick J., Van Den Brink Hilde, Weaver Nick A., Siero Jeroen C.W., Van Der Worp H. Bart, Braun Kees P.J., Leiner Tim, De Jong Pim A., Zwanenburg Jaco J.M., Doevendans Pieter A., Voskuil Michiel, Grotenhuis Heynric B. 11 Jan 2023, In: European heart journal open. 3 10 p.

Estimating the viscoelastic properties of the human brain at 7 T MRI using intrinsic MRE and nonlinear inversion

Burman Ingeberg Marius, Van Houten Elijah, Zwanenburg Jaco J.M. 2023, In: Human Brain Mapping. 44 , p. 6575-6591 17 p.

Theory for a non-invasive diagnostic biomarker for craniospinal diseases

Karimi Fariba, Neufeld Esra, Fallahi Arya, Boraschi Andrea, Zwanenburg Jaco J M, Spiegelberg Andreas, Kurtcuoglu Vartan, Kuster Niels 8 Dec 2022, In: NeuroImage: Clinical. 37 , p. 1-16

Cerebral hemodynamics during atrial fibrillation:Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging

Scarsoglio S., Saglietto A., Tripoli F., Zwanenburg J. J.M., Biessels G. J., De Ferrari G. M., Anselmino M., Ridolfi L. Dec 2022, In: Physics of Fluids. 34

Relationship between diameter asymmetry and blood flow in the pre-communicating (A1) segment of the anterior cerebral arteries

van Tuijl R J, Ruigrok Y M, Ophelders MEH, Vos I N, van der Schaaf I C, Zwanenburg JJM, Velthuis B K 15 Oct 2022, In: Journal of neuroradiology. 50 , p. 402-406 5 p.

CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI

van den Brink Hilde, Kopczak Anna, Arts Tine, Onkenhout Laurien, Siero Jeroen C W, Zwanenburg Jaco J M, Hein Sandra, Hübner Mathias, Gesierich Benno, Duering Marco, Stringer Michael S, Hendrikse Jeroen, Wardlaw Joanna M, Joutel Anne, Dichgans Martin, Biessels Geert Jan, 12 Oct 2022, In: Annals of Neurology. 93 , p. 29-39 11 p.

Reliability of velocity pulsatility in small vessels on 3Tesla MRI in the basal ganglia:a test-retest study

van Tuijl Rick J, Pham Stanley D T, Ruigrok Ynte M, Biessels Geert Jan, Velthuis Birgitta K, Zwanenburg Jaco J M 27 Sep 2022, In: Magma - Magnetic Resonance Materials In Physics Biology And Medicine. 36 , p. 15-23 9 p.

All research output

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