Fludarabine (English)

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EDTA-buis/2 ml (without gel!)

Minimal: 0,5 ml plasma

For sampling and logistics we refer to our standard operation procedure. Click the link below to download the full dosing, administrating and sampling protocol of Fludarabine at the UMC Utrecht.
Fludarabine English

Send the plasma samples on dry ice via overnight delivery to the UMC Utrecht pharmacology lab (see Address)

Plasma; -20 °C

Please copy this exact Dutch text:
UMC Utrecht
CDL lokatie G.03.330
Materiaal t.a.v. Laboratorium Apotheek
Heidelberglaan 100
3584 CX Utrecht
Nederland

LC-MS/MS

On request

AUC target: 15-25 mg*h/L

Fludarabine is the most frequently used agent in conditioning regimens for allogeneic hematopoietic cell transplantation

Optimal fludarabine exposure has been associated with improved treatment outcome in allogeneic hematopoietic cell transplantation, suggesting potential benefit of individualized dosing.

The  cumulative target area under the concentration curve (AUC) that we recommend for both adults and children is 20 mg*h/L (range 17.5-22.5 mg*h/L) [1].

For children who receive fludarabine prior to CAR T-cell infusion, we recommend a cumulative target AUC of 14-18 mg*h/L [2].

[1] Langenhorst et al. Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes. Blood Adv. 2019 Jul 23;3(14):2179-2187
[2] Dekker et al. Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia. Blood Adv. 2022;6(7):1969-1976.

ISO 15189 (M219), KF.TDM.02