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Group van Loosdregt-Vastert

About

Together Jorg van Loosdregt (fundamental scientists) and Bas Vastert (pediatric rheumatologist/scientist) lead the pediatric rheumatology translational research group in the University Medical Center Utrecht (The Netherlands). Our mission is to increase our understanding of the molecular mechanisms underlying Juvenile Idiopathic Arthritis (JIA), and translating these findings into novel therapeutics. JIA is a disease that affects 1/1000 children and can lead to impaired severe loss of quality of life. Our group combines both fundamental and clinically orientated research projects. We believe that bringing these fields of research, and researchers, together facilitates translational research allowing for more efficient transition of experimental findings to the clinic. 

Research programs

Infection and Immunity
Child Health

Research interests

Epigenetics and transcriptomics in JIA
Identification of therapeutic targets for JIA treatment
Clinical trials to improve JIA treatment and care

Contacts

Jorg van Loosdregt
J.vanLoosdregt@umcutrecht.nl

Related websites

Group members

Group leaders: Bas Vastert and Jorg van Loosdregt

Team photo

Postdoc

  • Dr. Jorg Calis (affiliated researcher)

Research technicians

  • Rianne Scholman
  • Yesper Smits

Clinician-Scientist

  • Arjen Leek

PhD students

  • Lucas Picavet
  • Lotte Nijhuis
  • Ellen van Vroonhoven
  • Anouk Verwoerd

Students

  • Sietske Gadella
  • Janneke Hulsen
  • Koen Heuvelmans

Join our group

PhD positions available 

Key Publications

  1. Ter Haar, N. M., et al. (2019). "Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five-Year Follow-Up Study." Arthritis Rheumatol 71(7): 1163-1173. View
  2. Ter Haar, N. M., et al. (2018). "Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis." Arthritis Rheumatol 70(6): 943-956. View
  3. Peeters, J. G., et al. (2015). "Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression." Cell Rep 12(12): 1986-1996. View
  4. van Loosdregt, J., et al. (2013). "Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity." Immunity 39(2): 259-271. View
  5. van Loosdregt, J., et al. (2013). "Canonical Wnt signaling negatively modulates regulatory T cell function." Immunity 39(2): 298-310. View

PhD theses

2019

Autoinflammation: from monogenic to complex diseases
Nienke ter Haar

2018 

Collaborations

Our research acitivities are closely linked to the department of Pediatric Rheumatology and Immunology in the Wilhelmina Children’s Hospital, University Medical Center Utrecht
Within the Center of Translational Immunoloy, we closely collaborate with the group of Femke van Wijk. Together we supervise 1 PhD student in a PhD trajectory on residential T cells in Synovial fluid in JIA.
We collaborate with multiple groups in the Netherlands and abroad

Grants

Prizes

Pediatric Rheumatology European Association - Young Investigator Meeting
Nienke ter Haar Best Basic Presentation (2015, 2018)

Dutch Pediatric Society (NVK) - Young Investigator Prize
Nienke ter Haar 3rd prize (2018)

Pediatric Rheumatology European Association
Lotte Nijhuis Kourir award 2018 for relevant research to patients (2018)

In the media

13 Dec 2018: Best Behandeling kinderen met jeugdreuma - UMC Utrecht

12 Oct 2018: Het Klokhuis - Jeugdreuma Watch

22 Aug 2016: ReumaNederlands - Jeugdreuma Watch