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Vorige

J.M.L. (Jeanine) Roodhart

Internist-Oncoloog

Aandachtsgebieden

Afdelingen / poliklinieken

Afdeling

Divisie

Wetenschappelijk onderzoek

  • 2007-2011 promotie-onderzoek UMC Utrecht bij prof dr. E.E. Voest  “Understanding the tumor-host interaction, the key to more effective anti-cancer treatment”, cum laude promotie april 2012. Link proefschrift: https://dspace.library.uu.nl/handle/1874/236768
  • 2009 Onderzoek aan University of California Los Angeles (UCLA) USA bij prof. L. Iruela-Arispe naar ‘the role of VE-cadherin positive bone marrow derived cells in therapy enhanced angiogenesis’.
  • 2017-heden opzetten verschillende (vroeg) klinische en translationele studies op het gebied van dikke darmkanker en organoiden. 

 

Persoonlijke prijzen, subsidies en onderscheidingen

  • Juni 2017 Geselecteerd voor deelname aan 19e ECCO-AACR-EORTC-ESMO Methods in Clinical Cancer Research (MCCR) workshop
  • November 2012 Oncologisch proefschrift van het jaar 2012, Nederlandse Vereniging van Medische Oncologie (NVMO) tijdens oncologie dagen voor Nederland en Vlaanderen
  • Augustus 2012  Izaak Korteweg en Anna Ida Overwater Award, for innovative and socially relevant research
  • April 2012 Cum Laude promotie
  • April 2012 Award for best presentation at the Dutch Internal Medicine conference (Internistendagen)
  • April 2011 AACR scolar-in-training-award
  • Oktober 2009 NWO AGIKO stipendium
  • November 2008 Pieter de Mulder award from the Dutch association for medical  oncology (NVMO) for excellent young scientist in cancer research
  • November 2008 Rene Vogels scholarship, by the Dutch oncology association, for excellent young scientist in cancer research

Publicaties

Key publicaties

  • JM Houthuijzen, I Oosterom, BD Hudson, A Hirasawa, LGM Daenen , CM McLean, SVF Hansen, MTM van Jaarsveld, DS Peeper, S Jafari Sadatmand, JML Roodhart, CHA van de Lest, T Ulven, K Ishihara, G Milligan, EE Voest. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance. FASEB J. 2017 May;31(5):2195-2209.
  • L.G. Daenen, G.A. Cirkel, J.M. Houthuijzen, J. Gerrits, I. Oosterom, J.M.L. Roodhart, H. van Tinteren, K. Ishihara, A.D. Huitema, N.M. Verhoeven-Duif , E.E. Voest. Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol. 2015 Jun 1;1(3):350-8.
  • J.M. Houthuijzen, L.G. Daenen, J.M.L. Roodhart, I. Oosterom, M.T. van Jaarsveld, K.M. Govaert, M.E. Smith, S.J. Sadatmand, H. Rosing, F. Kruse, B.J. Helms, N. van Rooijen, J.H. Beijnen, B. Haribabu , C.H. van de Lest, E.E. Voest. Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. Nat Commun. 2014 Nov 12;5:5275.
  • J.M.L. Roodhart, H. He, L.G.M. Daenen, A. Monvoisin, C.L. Barber, M. van Amersfoort, J. Hoffman,F. Radtke, T.F. Lane, E. E. Voest, M Luisa Iruela Arispe. Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance. Blood 2013 Jul 4;122(1):143-53
  • J.M. Houthuijzen, L.G.M. Daenen, J.M.L. Roodhart , E.E. Voest  The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression.Br J Cancer. 2012 Jun 5;106(12):1901-6
  • L.G.M. Daenen, J.M.L. Roodhart, M. van Amersfoort, M. Dehnad, W. Roessingh, L. Ulfman, P.W. Derksen, and E.E. Voest. Chemotherapy enhances metastasis formation in experimental mouse models via endothelial cell-intrinsic upregulation of VEGFR-1. Cancer Research 2011; Oct 5.
  • J.M.L. Roodhart, L.G.M. Daenen, E.C.A. Stigter, H. Prins, H.S. Schipper, M.J.G. Backer, M. van Amersfoort, J.S.P. Vermaat, P. Moerer, K. Ishihara, E. Kalkhoven, P.W.B. Derksen, R.H. Medema, A.C. Martens, A.B. Brenkman, E.E. Voest. Mesenchymal Stem Cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 2011; Sep 13;20(3):370-83.
  • J.M.L. Roodhart, M.H.G. Langenberg, J.S.P. Vermaat, M.P. Lolkema, A. Baars, A. de Graeff, P.O. Witteveen, Emile E. Voest. Changes in Circulating Endothelial Cells and Endothelial Progenitor Cells predict response to chemotherapy and progression free survival in a wide range of cancers. Neoplasia 2010; Jan 1;12(1):87-94.
  • J.M.L. Roodhart, M.H.G. Langenberg, L.G. Daenen, E.E. Voest. Translating preclincal findings of (endothelial) progenitor cell mobilization into the clinic; From bedside to bench and back. BBA-Reviews on Cancer 2009; Aug 1;1796(1):41-9.
  • Y. Shaked, E. Henke, J.M.L. Roodhart, P. Mancuso, M.H.G. Langenberg, M. Colleoni, L.G. Daenen, S.Man, P. Xu, U. Emmenegger, T. Tang, Z.Zhu, L. Witte, R. M. Strieter, F. Bertolini, E.E. Voest, R. Benezra, R.S. Kerbel. Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents. Cancer Cell 2008; Sep 9;14(3):263-73.

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