Research line 'Hemophilia, Von Willebrand disease and allied coagulation disorders'
The Van Creveldkliniek holds an international leading position in scientific research in the field of hemophilia, Von Willebrand disease and allied coagulation disorders. This includes innovative therapeutic and gene therapy studies, studies in joint damage, self management and adherence, sports, hemophilia carriers and registries.
Research includes both studies that are initiated by our researchers and studies that are being performed on behalf of pharmaceutical companies. An overview of currently active studies at the Van Creveldkliniek is shown in the table below.
| Study | Patient population | Description |
|---|---|---|
| 2BEGIN | Adults with severe hemophilia A | Study to detect sub-clinical joint bleeds and arthritis. |
| DISTRACTIE | Adults with hemophilia A and B with severe arthropathy of the ankle | Evaluation of the clinical efficacy of ankle joint distraction in hemophilia patients with severe arthropathy of the ankle. |
| DosEmi | Hemophilia | PK-guided Hemlibra dose reduction study. |
| e-Exercise | Hemophilia A and B | Face-to-face physiotherapy intervention integrated with the use of a mobile app. |
| EUHASS | Hemophilia A and B | European registry to collect concomitant effects of hemophilia |
| FRONTIER-4 | Hemophilia A | Long-term follow-up study to evaluate the safety and efficacy of MIM-8, a factor VIII by-passing agent |
| HOCUS-POCUS | Hemophilia A and B and Von Willebrand disease | Added value of point of care ultrasound |
| Hope-B | Adults with severe hemophilia B | Long-term follow-up study for gene therapy |
| HemoNED | All coagulation disorders | Dutch registry |
| HMBeacon | Girls (>12 yr) and women with Von Willebrand disease suffering from heavy menstrual bleeding (HMB) | Phase II study to investigate safety, tolerability and efficacy of ALN-6400, an siRNA compound directed against plasminogen |
| PedNet | Pediatric hemophilia A and B | European registry for inhibitor development |
| PHYSNET2 | Hemophilia A and B | Predictors of change in physical functioning. |
| PRIDES | Pregnant women with Von Willebrand's disease and hemopilia carriers | Pregnancy and Inherited Bleeding Disorders Study. |
| RedFlag | Women with Von Willebrand's disease, coagulation factor deficiencies, thrombocytopathies and hemophilia carriers | Registry study for women with heavy menstrual bleeding |
| XTEND-ed | Children with severe hemophilia A | Therapeutic study and its long-term follow-up study to the long-half life FVIII product BIVV001 |
| ZEBRHA1 | Patients with moderate or severe hemophilia A, aged 12 yr and older, who have been on long term prophylaxis and no FVIII inhibitors in the past 3 years | Comparison of NXT007 versus regular FXIII prophylaxis |
| ZEBRHA2 | Patients with mild, moderate and severe hemophilia A, with and without FVIII inhibitors, aged 12 yr and older | Comparison of NXT007 versus Hemlibra prophylaxis |
Cooperation between physiotherapists in haemophilia treatment centers and primary care - Merel Timmer (World Congres Physiotherapy 2021)
Cooperation between physiotherapists in haemophilia treatment centers and primary care - Merel Timmer (World Congres Physiotherapy 2021)
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Do you have any questions about participation in one of our studies? Or do you want to get in touch with one of our researchers? Please feel free to contact the research team of the Van Creveldkliniek.