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Vorige

Prof.dr. A.B.J. (Berent) Prakken

Hoogleraar Kinderimmunologie, Vice-decaan en Directeur van het Onderwijscentrum

T: (+31) 088 75 533 09 of polikliniek 088 75 752 41

E:

Aandachtsgebieden

Aandachtsgebieden

  • Vertaling van medische vooruitgang vanuit het laboratorium naar het ziekenhuis
  • Chronische inflammatie

Afdeling

  • Reumatologie/immunologie

Promotie

Datum promotie: 17-12-1996
Titel proefschrift: Heat shock proteins and the immunoregulation of chronic arthritis

Persoonlijke prijzen, subsidies en onderscheidingen

  • 2005 Jonxis penning and lecture University Medical Centre Groningen
  • 2003 Ter Meulen Lecture Dutch Society of Paediatrics
  • 2001 Kourir Award for best research project for novel treatment strategies in JuvenileIdiopathic Arthritis (European Society For Paediatric Rheumatology)
  • 1997 Young Investigators Award Dutch Society of Paediatrics1996 Cum Laude Thesis (University of Utrecht)
  • 1994 Young Investigators Bursary European Community Concerted Action on theimmunopathology of Chronic Arthritis

Wetenschappelijk onderzoek en publicaties

Publicaties

  • Prakken B, Wauben M, Genini D, Samodal R, Barnett J, Mendivil A, Leoni L,Albani S. 2000. Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'. Nat Med 6: 1406-10.
  • Prakken BJ, Wendling U, van der Zee R, Rutten VP, Kuis W, van Eden W. 2001.Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins. J Immunol 167: 4147-53.
  • Prakken BJ, Roord S, van Kooten PJ, Wagenaar JP, van Eden W, Albani S,Wauben MH. 2002. Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of anarthritis-related heat-shock protein 60 T cell epitope. Arthritis Rheum 46: 1937-46.
  • de Kleer IM, Kamphuis SM, Rijkers GT, Scholtens L, Gordon G, De Jager W,Hafner R, van de Zee R, van Eden W, Kuis W, Prakken BJ. 2003. Thespontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing theregulatory cytokine interleukin-10. Arthritis Rheum 48: 2001-10.
  • de Kleer IM, Wedderburn LR, Taams LS, Patel A, Varsani H, Klein M, de Jager W,Pugayung G, Giannoni F, Rijkers G, Albani S, Kuis W, Prakken B. 2004.CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 172:6435-43.